Cloned (Comment) | Organism |
---|---|
expressed in HEK293 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | co-expression of both UGT1A1 and UGT1A4 increases the Vmax values of UGT1A6-catalyzed serotonin and diclofenac O-glucuronide formation | Homo sapiens | |
additional information | - |
additional information | coexpression of UGT1A1 decreases the Vmax value of UGT1A4-catalyzed imipramine N-glucuronide formation but has no effect on UGT1A4-catalyzed trifluoperazine N-glucuronide formation. Coexpression of UGT1A6 has no effect on UGT1A4-catalyzed imipramine N-glucuronide formation but increases the Km and Vmax of UGT1A4-catalyzed trifluoperazine N-glucuronide formation | Homo sapiens | |
additional information | - |
additional information | imipramine N-glucuronide formation: Vmax (pmol/min/unit): 134.9, 110.4 (1A4 co-expressed with isoform 1A1), 126 (1A4 co-expressed with isoform 1A6). Trifluoperazine N-glucuronide formation: 2.1, 2.0 (1A4 co-expressed with isoform 1A1), 5.1 (1A4 co-expressed with isoform 1A6) | Homo sapiens | |
additional information | - |
additional information | serotonin O-glucuronide formation: Vmax (nmol/min/unit): 1.5, 2.1 (1A6 co-expressed with isoform 1A1), 6.1 (1A6 co-expressed with isoform 1A4). Diclofenac O-glucuronide formation: 0.0284, 0.088 (1A6 co-expressed with isoform 1A1), 0.0758 (1A6 co-expressed with isoform 1A4) | Homo sapiens | |
0.0197 | - |
Trifluoperazine | trifluoperazine N-glucuronide formation | Homo sapiens | |
0.0198 | - |
Trifluoperazine | trifluoperazine N-glucuronide formation, 1A4 co-expressed with isoform 1A4 | Homo sapiens | |
0.048 | - |
Trifluoperazine | trifluoperazine N-glucuronide formation, 1A4 co-expressed with isoform 1A6 | Homo sapiens | |
1.1 | - |
imipramine | imipramine N-glucuronide formation | Homo sapiens | |
1.4 | - |
imipramine | imipramine N-glucuronide formation, 1A4 co-expressed with isoform 1A4 | Homo sapiens | |
1.4 | - |
imipramine | imipramine N-glucuronide formation, 1A4 co-expressed with isoform 1A6 | Homo sapiens | |
3.7 | - |
serotonin | serotonin O-glucuronide formation, 1A4 co-expressed with isoform 1A6 | Homo sapiens | |
4.4 | - |
serotonin | serotonin O-glucuronide formation, 1A4 co-expressed with isoform 1A4 | Homo sapiens | |
4.6 | - |
serotonin | serotonin O-glucuronide formation | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
SDS-PAGE, each UGT1A isoform shows a single band at 50 to 55 kDa, owing to the differences in the levels of glycosylation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P22310 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronic acid + diclofenac | - |
Homo sapiens | UDP + diclofenac O-glucuronide | - |
? | |
UDP-glucuronic acid + imipramine | - |
Homo sapiens | UDP + imipramine N-glucuronide | - |
? | |
UDP-glucuronic acid + serotonin | - |
Homo sapiens | UDP + serotonin O-glucuronide | - |
? | |
UDP-glucuronic acid + trifluoperazine | - |
Homo sapiens | UDP + trifluoperazine N-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT 1A4 | - |
Homo sapiens |
UGT 1A6 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |