Information on EC 2.4.1.17 - glucuronosyltransferase

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EC Tree 2 Transferases 2.4 Glycosyltransferases 2.4.1 Hexosyltransferases 2.4.1.17 glucuronosyltransferase

This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

2.4.1.17
glucuronidation
hyperbilirubinemia
hepatocytes
irinotecan
gilbert
s-transferase
cyp3a4
phenobarbital
unconjugated
drug-metabolizing
disposition
pharmacogenetic
udp-glucuronic
interindividual
drug-drug
concentration-time
extrahepatic
acetaminophen
sulfotransferase
mycophenolic
neutropenia
pregnane
3-methylcholanthrene
benzoapyrene
o-deethylase
jaundice
androsterone
cyp2c9
drug development
endobiotics
slco1b1
vitro-in
lamotrigine
clint
sult1a1
herb-drug
propofol
atazanavir
diagnostics
cdna-expressed
cyp1b1
analysis
androstane
pharmacogenomics
raltegravir
7-ethoxyresorufin
aminopyrine
pharmacology
medicine
ethylmorphine
zidovudine
ethoxycoumarin
sults
beta-naphthoflavone
oatp1b1

Reaction Schemes

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UDP-alpha-D-glucuronate

acceptor

UDP

acceptor beta-D-glucuronoside

Synonyms
ugt1a1, udp-glucuronosyltransferase, ugt2b7, ugt1a9, ugt1a6, ugt1a, ugt2b17, ugt1a4, udp-glucuronyltransferase, udpgt, more

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UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

BRENDA

KEGG

Ascorbate and aldarate metabolism, Biosynthesis of secondary metabolites, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Steroid hormone biosynthesis

MetaCyc

heme degradation I, melatonin degradation I, nicotine degradation IV, nicotine degradation V, saponin biosynthesis II, serotonin degradation, thyroid hormone metabolism II (via conjugation and/or degradation)