Literature summary for 2.4.1.16 extracted from

Hwang, E.I.; Lee, Y.M.; Lee, S.M.; Yeo, W.H.; Moon, J.S.; Kang, T.H.; Park, K.D.; Kim, S.U.
Inhibition of chitin synthase 2 and antifungal activity of lignans from the stem bark of Lindera erythrocarpa (2007), Planta Med., 73, 679-682.

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of CHS isozymes in Saccharomyces cerevisiae strains	Saccharomyces cerevisiae
overexpression of CHS2p isozyme in Saccharomyces cerevisiae strains	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
kanakugiol	inhibition of chitin synthase 2 and antifungal activity of the lignan from the stem bark of Lindera erythrocarpa, overview	Saccharomyces cerevisiae
linderone	inhibition of chitin synthase 2 and antifungal activity of the lignan from the stem bark of Lindera erythrocarpa, overview	Saccharomyces cerevisiae
methyllinderone	inhibition of chitin synthase 2 and antifungal activity of the lignan from the stem bark of Lindera erythrocarpa, overview	Saccharomyces cerevisiae
additional information	no inhibition of chitin synthase 1 and 3 by methyllinderone, linderone, and kanakugiol from stem bark of Lindera erythrocarpa	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	and strain ECY38-38A, isozyme CHS2p encoded by gene CHS2	-
Saccharomyces cerevisiae	-	and strain ECY38-38A, isozymes CHS1p and CHS3p encoded by genes CHS1 and CHS3	-
Saccharomyces cerevisiae YPH499	-	and strain ECY38-38A, isozyme CHS2p encoded by gene CHS2	-
Saccharomyces cerevisiae YPH499	-	and strain ECY38-38A, isozymes CHS1p and CHS3p encoded by genes CHS1 and CHS3	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
chitin synthase 2	-	Saccharomyces cerevisiae
CHS1p	-	Saccharomyces cerevisiae
CHS2p	-	Saccharomyces cerevisiae
Chs3p	-	Saccharomyces cerevisiae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0214	-	-	Saccharomyces cerevisiae	linderone
0.0233	-	-	Saccharomyces cerevisiae	methyllinderone
0.0238	-	-	Saccharomyces cerevisiae	kanakugiol

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Release 2023.1 (January 2023)