Crystallization (Comment) | Organism |
---|---|
full structure of human ACLY homotetramer in ternary complex with the inhibitor and ADP with an overall resolution of 3.67 A | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methyl 3-chloro-5-(N-(4,6-difluoro-[1,1'-biphenyl]-3-yl)sulfamoyl)-4-hydroxybenzoate | i.e. NDI-091143, allosteric inhibition | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + citrate + CoA | Homo sapiens | the enzyme links glycolysis to lipid metabolism | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P53396 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + citrate + CoA | - |
Homo sapiens | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? | |
ATP + citrate + CoA | the enzyme links glycolysis to lipid metabolism | Homo sapiens | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ACLY | - |
Homo sapiens |
ATP-citrate lyase | - |
Homo sapiens |