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Literature summary for 2.3.3.10 extracted from

  • Mathews, E.S.; Mawdsley, D.J.; Walker, M.; Hines, J.H.; Pozzoli, M.; Appel, B.
    Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression (2014), J. Neurosci., 34, 3402-3412.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.3.10

Protein Variants

Protein Variants Comment Organism
H189Q the mutation disrupts enzyme function and diminishes cholesterol synthesis Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + H2O + acetoacetyl-CoA Danio rerio
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio Q7ZWE2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
 Danio rerio
-
oligodendrocyte
-
 Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + acetoacetyl-CoA
-
 Danio rerio (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl CoA synthase I
-
 Danio rerio
HMGCS1
-
 Danio rerio

General Information

General Information Comment Organism
physiological function oligodendrocyte progenitor cell migration and myelin gene expression require enzyme function of 3-hydroxy-3-methylglutaryl CoA synthase I Danio rerio