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Literature summary for 2.3.1.B43 extracted from

  • Du, Y.; Hu, H.; Hua, C.; Du, K.; Wei, T.
    Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms (2018), Biochem. Biophys. Res. Commun., 503, 763-769 .
    View publication on PubMed
Search for more literature for 2.3.1.B43

Cloned(Commentary)

Cloned (Comment) Organism
SIRT5 isozymes, DNA and amino acid sequence determination and analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm SIRT5 isozyme 4 is mainly localized in the cytoplasm Homo sapiens 5737
-
mitochondrion SIRT5 isozymes 1, 2 and 3 are mitochondria-localized. The full-length SIRT5 protein (SIRT5iso1) contains the N-terminal 36 amino acid mitochondrial localization signal (MLS) peptide Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXA8
-
-

Purification (Commentary)

Purification (Comment) Organism
purification of SIRT5 isozymes from HepG2 cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
16-HBE14o cell
-
 Homo sapiens
-
A-549 cell
-
 Homo sapiens
-
adipose tissue
-
 Homo sapiens
-
bladder
-
 Homo sapiens
-
blood
-
 Homo sapiens
-
bone
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
connective tissue
-
 Homo sapiens
-
embryo
-
 Homo sapiens
-
esophagus
-
 Homo sapiens
-
eye
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
HHL-5 cell
-
 Homo sapiens
-
HL-7702 cell
-
 Homo sapiens
-
hypophysis
-
 Homo sapiens
-
intestine
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
lymph node
-
 Homo sapiens
-
mammary gland
-
 Homo sapiens
-
additional information the SIRT5 gene is widely expressed, but expression patterns of different isoforms vary in tissues, expression analysis, overview Homo sapiens
-
mouth
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-
neuron SIRT5 isozyme 2 Homo sapiens
-
pancreas
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
prostate gland
-
 Homo sapiens
-
skin
-
 Homo sapiens
-
stomach
-
 Homo sapiens
-
testis
-
 Homo sapiens
-
thymus
-
 Homo sapiens
-
thyroid gland
-
 Homo sapiens
-
trachea
-
 Homo sapiens
-
uterine cervix
-
 Homo sapiens
-
uterus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information synthsis of substrate peptide (2-Abz)-GVLK (succ)A [Y (3-NO2)]GV-NH2 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 34000, isozyme SIRT5iso1, SDS-PAGE Homo sapiens
additional information the full-length SIRT5 protein (SIRT5iso1) contains the N-terminal 36 amino acid mitochondrial localization signal peptide and the remaining NAD+-dependent deacylase domain Homo sapiens

Synonyms

Synonyms Comment Organism
SIRT5
-
 Homo sapiens
SIRT5iso1
-
 Homo sapiens
SIRT5iso2
-
 Homo sapiens
SIRT5iso3
-
 Homo sapiens
SIRT5iso4
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

General Information

General Information Comment Organism
evolution SIRT5 gene encodes for four SIRT5 protein isoforms, namely SIRT5iso1, SIRT5iso2, SIRT5iso3, and SIRT5iso4 Homo sapiens
physiological function potential role of isozyme SIRT5iso2 in neuron system Homo sapiens