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Literature summary for 2.3.1.75 extracted from

  • Barney, B.M.; Ohlert, J.M.; Timler, J.G.; Lijewski, A.M.
    Altering small and medium alcohol selectivity in the wax ester synthase (2015), Appl. Microbiol. Biotechnol., 99, 9675-9684.
    View publication on PubMed
Search for more literature for 2.3.1.75

Protein Variants

Protein Variants Comment Organism
L356A mutation increases selectivity toward ethanol Marinobacter nauticus
L356F mutation increases selectivity toward ethanol, with a drop in specific activity of approximately 89% for dodecanol Marinobacter nauticus
L356V mutation increases selectivity toward 2-phenylethanol Marinobacter nauticus
L356Y substantial loss of activity Marinobacter nauticus
M405A significant decrease in overall activity with dodecanol Marinobacter nauticus
M405F mutation increases selectivity toward isoamyl alcohol, significant decrease in overall activity with dodecanol Marinobacter nauticus
M405L significant decrease in overall activity with dodecanol Marinobacter nauticus
M405W dramatically shifts selectivity toward ethanol, significant decrease in overall activity with dodecanol Marinobacter nauticus

Inhibitors

Inhibitors Comment Organism Structure
ethanol substrate inhibition above 0.5 M Marinobacter nauticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4
-
 hexan-1-ol wild-type, temperature not specified in the publication, pH not specified in the publication Marinobacter nauticus
5.6
-
 isoamyl alcohol wild-type, temperature not specified in the publication, pH not specified in the publication Marinobacter nauticus

Organism

Organism UniProt Comment Textmining
Marinobacter nauticus A1TX06
-
-
Marinobacter nauticus DSM 11845 A1TX06
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phenylethanol + palmitoyl-CoA
-
 Marinobacter nauticus 2-phenylethyl palmitate + CoA
-
 ?
2-phenylethanol + palmitoyl-CoA
-
 Marinobacter nauticus DSM 11845 2-phenylethyl palmitate + CoA
-
 ?
ethanol + palmitoyl-CoA
-
 Marinobacter nauticus ethyl palmitate + CoA
-
 ?
ethanol + palmitoyl-CoA
-
 Marinobacter nauticus DSM 11845 ethyl palmitate + CoA
-
 ?
hexan-1-ol + palmitoyl-CoA
-
 Marinobacter nauticus hexyl palmitate + CoA
-
 ?
hexan-1-ol + palmitoyl-CoA
-
 Marinobacter nauticus DSM 11845 hexyl palmitate + CoA
-
 ?
isoamyl alcohol + palmitoyl-CoA
-
 Marinobacter nauticus isoamyl palmitate + CoA
-
 ?
isoamyl alcohol + palmitoyl-CoA
-
 Marinobacter nauticus DSM 11845 isoamyl palmitate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
Maqu_0168
-
 Marinobacter nauticus