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Information on EC 2.3.1.75 - long-chain-alcohol O-fatty-acyltransferase

for references in articles please use BRENDA:EC2.3.1.75

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IUBMB Comments

The enzyme transfers acyl residues from acyl-CoA to long-chain alcohols, forming wax esters. Wax esters have diverse biological functions in bacteria, insects, mammals, and terrestrial plants. The enzyme from the plant Simmondsia chinensis (jojoba) prefers acyl residues of chain-length C18 to C20 and its preferred acceptor is (11Z)-icos-11-en-1-ol. cf. EC 2.3.1.332, medium-chain-alcohol O-fatty-acyltransferase.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
acyl-coa:retinol acyltransferase, wax synthase, wax ester synthase, awat2, awat1, wax ester synthase/diacylglycerol acyltransferase, atfa1, wax ester synthase/acyl-coenzyme a:diacylglycerol acyltransferase, maqu_0168, acyl-coa wax alcohol acyltransferases, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + a long-chain alcohol = CoA + a long-chain alcohol wax ester
show the reaction diagram
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acyl-CoA + a long-chain alcohol = CoA + a long-chain ester
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
cuticular wax biosynthesis, long chain fatty acid ester synthesis (engineered), wax esters biosynthesis I, wax esters biosynthesis II
Highest Expressing Human Cell Lines
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