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Literature summary for 2.3.1.296 extracted from

  • Kien, B.; Grond, S.; Haemmerle, G.; Lass, A.; Eichmann, T.O.; Radner, F.P.W.
    ABHD5 stimulates PNPLA1-mediated omega-O-acylceramide biosynthesis essential for a functional skin permeability barrier (2018), J. Lipid Res., 59, 2360-2367 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.296

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Mus musculus
expressed in HEK-293T cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a linoleate-containing triacyl-sn-glycerol + an ultra-long-chain omega-hydroxyceramide Mus musculus
-
 a diacyl-sn-glycerol + a linoleate-esterified acylceramide
-
 ir
a linoleate-containing triacyl-sn-glycerol + an ultra-long-chain omega-hydroxyceramide Homo sapiens
-
 a diacyl-sn-glycerol + a linoleate-esterified acylceramide
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Mus musculus
-
keratinocyte
-
 Homo sapiens
-
white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a linoleate-containing triacyl-sn-glycerol + an ultra-long-chain omega-hydroxyceramide
-
 Mus musculus a diacyl-sn-glycerol + a linoleate-esterified acylceramide
-
 ir
a linoleate-containing triacyl-sn-glycerol + an ultra-long-chain omega-hydroxyceramide
-
 Homo sapiens a diacyl-sn-glycerol + a linoleate-esterified acylceramide
-
 ir
additional information ABHD5 is a coactivator of the enzyme that stimulates the esterification of omega-hydroxy ceramides with linoleic acid for omega-O-acylceramide biosynthesis Mus musculus ?
-
 ?
additional information ABHD5 is a coactivator of the enzyme that stimulates the esterification of omega-hydroxy ceramides with linoleic acid for omega-O-acylceramide biosynthesis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
patatin-like phospholipase domain-containing 1
-
 Mus musculus
patatin-like phospholipase domain-containing 1
-
 Homo sapiens
PNPLA1
-
 Mus musculus
PNPLA1
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the final step in omega-O-acylceramide biosynthesis Mus musculus
metabolism the enzyme catalyzes the final step in omega-O-acylceramide biosynthesis Homo sapiens