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Information on EC 2.3.1.296 - omega-hydroxyceramide transacylase

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EC Tree
IUBMB Comments
The enzyme participates in the production of acylceramides in the stratum corneum, the outermost layer of the epidermis. Acylceramides are crucial components of the skin permeability barrier.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
a linoleate-containing triacyl-sn-glycerol
+
an ultra-long-chain omega-hydroxyceramide
=
a diacyl-sn-glycerol
+
a linoleate-esterified acylceramide
Synonyms
omega-hydroxyceramide transacylase, patatin-like phospholipase domain-containing 1, patatin-like phospholipase domain-containing lipase 1, PNPLA1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a linoleate-containing triacyl-sn-glycerol + an ultra-long-chain omega-hydroxyceramide = a diacyl-sn-glycerol + a linoleate-esterified acylceramide
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PATHWAY SOURCE
PATHWAYS
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