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Literature summary for 2.3.1.244 extracted from

  • Meehan, M.J.; Xie, X.; Zhao, X.; Xu, W.; Tang, Y.; Dorrestein, P.C.
    FT-ICR-MS characterization of intermediates in the biosynthesis of the alpha-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF (2011), Biochemistry, 50, 287-299.
    View publication on PubMed
Search for more literature for 2.3.1.244

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
277000
-
-
 Aspergillus terreus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine Aspergillus terreus the enzyme is involved in the lovastatin biosynthetic pathway (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus terreus Q9Y7D5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine the enzyme is involved in the lovastatin biosynthetic pathway Aspergillus terreus (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O
-
 ?
acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine the overall reaction comprises a single condensation reaction followed by alpha-methylation, beta-ketoreduction, dehydration, and alpha,beta enoyl reduction Aspergillus terreus (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O
-
 ?

Subunits

Subunits Comment Organism
? 277000, calculated from sequence Aspergillus terreus

Synonyms

Synonyms Comment Organism
LocF
-
 Aspergillus terreus

Cofactor

Cofactor Comment Organism Structure
4'-phosphopantetheine covalently bound Aspergillus terreus

General Information

General Information Comment Organism
metabolism the enzyme is involved in the lovastatin biosynthetic pathway Aspergillus terreus