BRENDA - Enzyme Database
show all sequences of 2.3.1.16

A unique, membrane-bound, multifunctional enzyme from human liver mitochondria catalysing three steps of fatty acid beta-oxidation

Carpenter, K.; Pollitt, R.J.; Middleton, B.; Biochem. Soc. Trans. 21, 35S (1992)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrial membrane
-
Homo sapiens
31966
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
CoA + 3-oxoacyl-CoA
Homo sapiens
enzyme catalyses step of fatty acid beta-oxidation
acyl-CoA + acetyl-CoA
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Reaction
Reaction
Commentary
Organism
Reaction ID
acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA
multifunctional enzyme: 2-enoyl-CoA hydratase, 3-ketoacyl-CoA thiolase and long-chain specific 3-hydroxyacyl-CoA dehydrogenase
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
CoA + 3-oxoacyl-CoA
-
486411
Homo sapiens
acyl-CoA + acetyl-CoA
-
486411
Homo sapiens
?
CoA + 3-oxoacyl-CoA
enzyme catalyses step of fatty acid beta-oxidation
486411
Homo sapiens
acyl-CoA + acetyl-CoA
-
-
-
-
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrial membrane
-
Homo sapiens
31966
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
CoA + 3-oxoacyl-CoA
Homo sapiens
enzyme catalyses step of fatty acid beta-oxidation
acyl-CoA + acetyl-CoA
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
CoA + 3-oxoacyl-CoA
-
486411
Homo sapiens
acyl-CoA + acetyl-CoA
-
486411
Homo sapiens
?
CoA + 3-oxoacyl-CoA
enzyme catalyses step of fatty acid beta-oxidation
486411
Homo sapiens
acyl-CoA + acetyl-CoA
-
-
-
-
Other publictions for EC 2.3.1.16
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735368
Kiema
The crystal structure of human ...
Homo sapiens
Acta Crystallogr. Sect. D
70
3212-3225
2014
-
-
1
1
2
-
-
2
2
-
-
4
-
3
-
-
1
1
-
4
-
-
6
1
1
1
-
-
2
1
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
2
2
-
-
4
-
-
-
1
-
4
-
-
6
1
1
-
-
2
1
-
-
-
-
3
3
-
-
-
719014
Fidaleo
A role for the peroxisomal 3-k ...
Mus musculus
Biochimie
93
876-891
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
720658
Jiang
Arabidopsis 3-ketoacyl-CoA thi ...
Arabidopsis thaliana
Plant Cell Physiol.
52
528-538
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705007
Green
Role of fatty acid elongases i ...
Rattus norvegicus
J. Lipid Res.
51
1871-1877
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
716755
Teufel
Bacterial phenylalanine and ph ...
Pseudomonas sp., Pseudomonas sp. Y2
Proc. Natl. Acad. Sci. USA
107
14390-14395
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
2
-
3
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
717129
Forster-Fromme
Catabolism of citronellol and ...
Pseudomonas citronellolis
Appl. Microbiol. Biotechnol.
87
859-869
2010
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719874
Pye
Peroxisomal plant 3-ketoacyl-C ...
Arabidopsis thaliana, Helianthus annuus
J. Biol. Chem.
285
24078-24088
2010
-
-
-
2
-
-
2
-
3
-
-
-
-
5
-
-
-
-
-
-
-
2
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720900
Berdichevsky
3-Ketoacyl thiolase delays agi ...
Caenorhabditis elegans
Proc. Natl. Acad. Sci. USA
107
18927-18932
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
702428
Qin
Regulation of hepatic fatty ac ...
Mus musculus
Biochim. Biophys. Acta
1791
140-147
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
702657
Sasaki
Synthesis and evaluation of a ...
Homo sapiens
Bioorg. Med. Chem.
17
5639-5647
2009
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705035
Takahashi
Synthesis and evaluation of a ...
Homo sapiens, Mus musculus
J. Med. Chem.
52
3142-3145
2009
-
-
-
-
-
-
7
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
6
7
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705039
Nagase
Synthesis and biological evalu ...
Homo sapiens
J. Med. Chem.
52
4111-4114
2009
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705053
Mizutani
Discovery of novel benzoxazino ...
Homo sapiens
J. Med. Chem.
52
7289-7300
2009
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
4
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705468
Iskandarov
Cloning and characterization o ...
Lobosphaera incisa
Lipids
44
545-554
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
706081
Magnucka
Cycloate, an inhibitor of fatt ...
Secale cereale
Pest Manag. Sci.
65
1065-1070
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686251
Fragasso
Modulation of fatty acids oxid ...
Homo sapiens
Curr. Clin. Pharmacol.
2
190-196
2007
-
1
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664215
Yamashita
Acetate generation in rat live ...
Rattus norvegicus
Biochim. Biophys. Acta
1761
17-23
2006
1
-
-
-
-
-
2
3
2
-
-
2
-
2
-
-
1
-
-
6
1
-
10
-
1
-
-
-
-
1
-
-
1
2
-
-
1
-
-
1
-
-
-
-
2
2
3
2
-
-
2
-
-
-
1
-
6
1
-
10
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
675383
Sundaramoorthy
The crystal structure of a pla ...
Arabidopsis thaliana
J. Mol. Biol.
359
347-357
2006
-
-
1
1
-
-
-
-
3
-
2
1
-
4
-
1
1
1
-
-
-
-
1
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
3
-
2
1
-
-
1
1
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676105
Elliott
Overexpression of a 3-ketoacyl ...
Leptosphaeria maculans
Mol. Plant Microbe Interact.
19
588-596
2006
-
-
1
-
1
-
-
-
1
-
-
-
-
7
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674357
Ito
Identification of Pex5pM, and ...
Cricetulus griseus
J. Biochem.
138
781-790
2005
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675941
Pantazaki
A thermostable beta-ketothiola ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Mol. Cell. Biochem.
269
27-36
2005
2
-
-
-
-
-
2
4
-
2
2
4
-
92
-
-
1
1
1
-
1
-
4
1
1
1
-
2
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
4
-
2
2
4
-
-
-
1
1
-
1
-
4
1
1
-
2
-
1
-
-
-
-
-
-
-
-
-
657848
Takeuchi
Characterization of a sterol c ...
Spodoptera littoralis
Biochem. J.
382
93-100
2004
-
-
1
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
658349
Chevillard
Molecular cloning, gene struct ...
Mus musculus
BMC Biochem.
5
3
2004
-
-
1
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
-
6
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
10
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660426
Schiedel
Cloning, expression, and purif ...
Helianthus annuus
Protein Expr. Purif.
33
25-33
2004
-
-
1
-
-
-
-
-
1
-
1
-
-
4
-
-
1
-
-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660434
Zeng
Expression and purification of ...
Rattus norvegicus
Protein Expr. Purif.
35
320-326
2004
-
-
1
-
4
-
-
5
3
-
-
1
-
5
-
-
1
-
-
1
1
1
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
5
3
-
-
1
-
-
-
1
-
1
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657502
Kim
-
A cDNA encoding 3-ketoacyl-CoA ...
Glycine max
Agric. Chem. Biotechnol.
46
87-91
2003
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486430
Oeljeklaus
Glyoxysomal acetoacetyl-CoA th ...
Helianthus annuus
Planta
214
597-607
2002
-
-
-
-
-
-
1
2
2
-
2
-
-
2
-
-
1
-
-
2
2
-
4
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
2
-
2
-
-
-
-
1
-
2
2
-
4
1
-
-
-
1
1
1
-
-
-
-
-
-
-
-
486438
Germain
Requirement for 3-ketoacyl-CoA ...
Arabidopsis thaliana
Plant J.
28
1-12
2001
-
-
1
-
-
-
-
-
-
-
-
2
-
5
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486435
Antonenkov
Comparison of the stability an ...
Rattus norvegicus
Biochim. Biophys. Acta
1437
136-141
1999
-
-
-
-
-
-
1
1
2
-
2
-
-
2
-
-
1
-
-
2
2
-
5
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
2
-
-
-
-
1
-
2
2
-
5
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
486437
Latruffe
Studies on regulation of the p ...
Rattus norvegicus
Adv. Exp. Med. Biol.
466
253-259
1999
-
-
-
-
-
-
-
-
3
-
-
1
-
3
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486436
Kanayama
Genetic evaluation of physiolo ...
Candida tropicalis
J. Bacteriol.
180
690-698
1998
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288682
Olesen
The glyoxysomal 3-ketoacyl-CoA ...
Brassica napus
FEBS Lett.
412
138-140
1997
-
-
1
-
-
-
-
-
4
-
-
1
-
4
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486433
Mathieu
The 1.8 A crystal structure of ...
Saccharomyces cerevisiae
J. Mol. Biol.
273
714-728
1997
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288673
Middleton
The mitochondrial long-chain t ...
Homo sapiens
Biochem. Soc. Trans.
22
427-431
1994
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288674
Seedorf
Sterol carrier protein x is pe ...
Rattus norvegicus
J. Biol. Chem.
269
21277-21283
1994
-
-
1
-
-
-
2
1
1
-
-
1
-
1
-
-
-
1
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
2
2
1
1
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288675
Erdmann
Purification and immunolocaliz ...
Saccharomyces cerevisiae
Yeast
10
1173-1182
1994
-
-
-
-
-
-
1
-
2
-
2
1
-
2
-
-
1
-
-
-
1
2
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
2
1
-
-
-
1
-
-
1
2
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486431
Mathieu
The 2.8 ANG. crystal structure ...
Saccharomyces cerevisiae
Structure
2
797-808
1994
-
1
-
1
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288681
Uchida
Novel fatty acid beta-oxidatio ...
Rattus norvegicus
J. Biol. Chem.
267
1034-1041
1992
-
-
-
-
-
-
-
-
1
-
3
2
-
3
-
-
1
1
-
1
2
-
5
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
3
2
-
-
-
2
-
1
2
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486411
Carpenter
A unique, membrane-bound, mult ...
Homo sapiens
Biochem. Soc. Trans.
21
35S
1992
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486413
Sato
Primary structures of the gene ...
Pseudomonas fragi, Pseudomonas fragi B-0771
J. Biochem.
111
8-15
1992
-
-
1
-
-
-
-
-
-
-
-
-
-
6
-
-
-
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486417
Wrensford
An acyl-coenzyme A chain lengt ...
Bos taurus, Sus scrofa
Anal. Biochem.
192
49-54
1991
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
2
-
4
2
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
4
2
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2213
Imamura
Purification of the multienzym ...
Pseudomonas fragi
J. Biochem.
107
184-189
1990
-
-
-
-
-
-
-
-
-
-
3
1
-
2
-
-
1
1
-
-
1
-
2
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
1
-
-
-
1
-
-
1
-
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486418
Zeelen
Crystallographic studies of 3- ...
Saccharomyces cerevisiae
J. Mol. Biol.
215
211-213
1990
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
487691
O'Connell
Purification and characterizat ...
Caulobacter vibrioides
J. Bacteriol.
172
997-1004
1990
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
-
1
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
288676
Kurihara
Peroxisomal acetoacetyl-CoA th ...
Candida tropicalis
J. Biochem.
106
474-478
1989
-
-
-
-
-
-
-
6
4
-
2
-
-
4
-
-
1
-
-
2
1
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
4
-
2
-
-
-
-
1
-
2
1
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486409
Li
4-Bromo-2-octenoic acid specif ...
Rattus norvegicus
Biochemistry
27
5995-6000
1988
-
-
-
-
-
-
1
-
2
-
-
-
-
2
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486427
Haywood
-
Characterization of two 3-keto ...
Cupriavidus necator
FEMS Microbiol. Lett.
52
91-96
1988
-
-
-
-
-
-
5
2
-
-
2
-
-
1
-
-
1
1
-
-
-
-
8
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
2
-
-
2
-
-
-
-
1
-
-
-
-
8
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486422
Arakawa
cDNA-derived amino acid sequen ...
Rattus norvegicus
EMBO J.
6
1361-1366
1987
-
-
1
-
-
-
-
-
4
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
33713
Sumegi
Binding of the enzymes of fatt ...
Sus scrofa
J. Biol. Chem.
259
8748-8752
1984
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2207
Pawar
The structure of the multienzy ...
Escherichia coli
J. Biol. Chem.
256
3894-3899
1981
-
-
-
-
-
-
1
-
-
-
3
-
-
1
-
-
1
1
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
1
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2962
Binstock
Fatty acid oxidation complex f ...
Escherichia coli
Methods Enzymol.
71
403-411
1981
-
-
-
-
-
1
-
2
-
-
1
2
-
1
-
-
1
1
-
1
1
1
7
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
2
-
-
-
1
-
1
1
1
7
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
288678
Miyazawa
Properties of peroxisomal 3-ke ...
Rattus norvegicus
J. Biochem.
90
511-519
1981
-
-
-
-
-
-
-
1
2
-
4
-
-
2
-
-
-
1
-
1
-
-
6
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
4
-
-
-
-
-
-
1
-
-
6
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
486404
Schulz
-
3-Ketoacyl-Co-A-thiolase with ...
Sus scrofa
Methods Enzymol.
71
389-403
1981
-
-
-
-
-
2
3
5
1
-
2
1
-
1
-
-
1
-
-
1
2
1
8
1
-
-
-
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
2
-
3
-
5
1
-
2
1
-
-
-
1
-
1
2
1
8
1
-
-
1
-
1
1
1
-
-
-
-
-
-
-
486424
Krahling
Peroxisomal beta-ketothiolase ...
Rattus norvegicus
Arch. Biochem. Biophys.
209
100-110
1981
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
1
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
288677
Miyazawa
The presence of a new 3-oxoacy ...
Rattus norvegicus
Eur. J. Biochem.
103
589-596
1980
-
-
-
-
-
-
-
1
2
-
-
-
-
2
-
-
1
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
1
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486408
Olowe
Regulation of thiolases from p ...
Sus scrofa
Eur. J. Biochem.
109
425-429
1980
-
-
-
-
-
-
2
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486420
Frevert
Purification of glyoxysomal ac ...
Cucumis sativus
Hoppe-Seyler's Z. Physiol. Chem.
361
537-542
1980
-
-
-
-
-
-
-
-
1
-
2
-
-
2
-
-
1
-
-
3
-
-
1
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
1
-
3
-
-
1
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
2206
Pramanik
Five different enzymatic activ ...
Escherichia coli
J. Bacteriol.
137
469-473
1979
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286604
Middleton
3-Oxoacyl-coenzyme A thiolases ...
Escherichia coli, Saccharomyces cerevisiae
Biochem. Soc. Trans.
6
80-83
1978
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486412
Staack
Purification and properties of ...
Sus scrofa
J. Biol. Chem.
253
1827-1831
1978
-
-
-
-
-
-
-
5
-
-
2
1
-
4
-
-
1
-
-
1
1
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
2
1
-
-
-
1
-
1
1
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486426
O'Brien
Evidence for a complex of thre ...
Escherichia coli
J. Bacteriol.
132
532-540
1977
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486403
Middleton
-
3-Ketoacyl-CoA thiolase of mam ...
Bos taurus, Ovis aries, Rattus norvegicus, Sus scrofa
Methods Enzymol.
35 B
128-136
1975
-
-
-
-
-
-
-
2
4
-
-
-
-
4
-
-
2
-
-
9
-
1
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
4
-
-
-
-
-
-
2
-
9
-
1
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486410
Feigenbaum
Thiolases of Escherichia coli: ...
Escherichia coli
J. Bacteriol.
122
407-411
1975
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-