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Information on EC 2.3.1.16 - acetyl-CoA C-acyltransferase

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EC Tree
IUBMB Comments
The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation. The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl-CoA shortened by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. In the second step the acyl group is transferred to CoA. Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9, acetyl-CoA C-acetyltransferase.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
elovl6, elovl5, 3-ketoacyl-coa thiolase, beta-ketothiolase, 3-oxoacyl-coa thiolase, acaa2, 3-ketothiolase, elovl-6, thiolase i, thiolase a, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA
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acyl-CoA + [acetyl-CoA C-acyltransferase]-L-cysteine = [acetyl-CoA C-acyltransferase]-S-acyl-L-cysteine + CoA
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(1b)
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0
[acetyl-CoA C-acyltransferase]-S-acyl-L-cysteine + acetyl-CoA = 3-oxoacyl-CoA + [acetyl-CoA C-acyltransferase]-L-cysteine
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(1a)
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0
PATHWAY SOURCE
PATHWAYS
MetaCyc
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase), (8E,10E)-dodeca-8,10-dienol biosynthesis, (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered), 10-cis-heptadecenoyl-CoA degradation (yeast), 10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast), 10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast), 2-deoxy-D-ribose degradation II, 2-methyl-branched fatty acid beta-oxidation, 2-methylpropene degradation, 3-hydroxypropanoate/4-hydroxybutanate cycle, 4-ethylphenol degradation (anaerobic), 4-hydroxybenzoate biosynthesis III (plants), 4-oxopentanoate degradation, 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast), acetoacetate degradation (to acetyl CoA), acetyl-CoA fermentation to butanoate II, androsrtendione degradation II (anaerobic), androstenedione degradation I (aerobic), cholesterol degradation to androstenedione I (cholesterol oxidase), cholesterol degradation to androstenedione II (cholesterol dehydrogenase), crotonate fermentation (to acetate and cyclohexane carboxylate), docosahexaenoate biosynthesis III (6-desaturase, mammals), ethylmalonyl-CoA pathway, fatty acid beta-oxidation I (generic), fatty acid beta-oxidation II (plant peroxisome), fatty acid beta-oxidation VI (mammalian peroxisome), fatty acid beta-oxidation VII (yeast peroxisome), fatty acid salvage, glutaryl-CoA degradation, isoprene biosynthesis II (engineered), isopropanol biosynthesis (engineered), jasmonic acid biosynthesis, ketogenesis, ketolysis, L-glutamate degradation V (via hydroxyglutarate), L-isoleucine degradation I, L-lysine fermentation to acetate and butanoate, methyl tert-butyl ether degradation, mevalonate pathway I (eukaryotes and bacteria), mevalonate pathway II (haloarchaea), mevalonate pathway III (Thermoplasma), mevalonate pathway IV (archaea), oleate beta-oxidation, platensimycin biosynthesis, polyhydroxybutanoate biosynthesis, propanoate fermentation to 2-methylbutanoate, pyruvate fermentation to acetone, pyruvate fermentation to butanoate, pyruvate fermentation to butanol I, pyruvate fermentation to butanol II (engineered), pyruvate fermentation to hexanol (engineered), sitosterol degradation to androstenedione, valproate beta-oxidation