Literature summary for 2.3.1.140 extracted from

Jiang, J.; Bi, H.; Zhuang, Y.; Liu, S.; Liu, T.; Ma, Y.
Engineered synthesis of rosmarinic acid in Escherichia coli resulting production of a new intermediate, caffeoyl-phenyllactate (2016), Biotechnol. Lett., 38, 81-88 .

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Application

Application	Comment	Organism
synthesis	expression of rosmarinic acid synthase from Coleus blumei, 4-coumarate: CoA ligase from Arabidopsis thaliana, 4-hydroxyphenyllactate 3-hydroxylase from Escherichia coli and D-lactate dehydrogenase from Lactobacillus pentosus in an L-tyrosine over-producing Escherichia coli strain leads to a yield of rosmarinic acid of 130 mg/l. In addition, intermediate caffeoyl-phenyllactate is produced at about 55 mg/l	Coleus scutellarioides

Organism

Organism	UniProt	Comment	Textmining
Coleus scutellarioides	A0PDV5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate	-	Coleus scutellarioides	CoA + rosmarinate	-	?
caffeoyl-CoA + phenyllactate	-	Coleus scutellarioides	CoA + 2-O-caffeoyl-3-phenyllactate	-	?

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Release 2023.1 (January 2023)