BRENDA - Enzyme Database show
show all sequences of 2.2.1.5

Oxalate metabolism in thiamine-deficient rats

Sidhu, H.; Gupta, R.; Thind, S.K.; Nath, R.; Ann. Nutr. Metab. 31, 354-361 (1987)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
involved in renal stone formation, decreased activity due to thiamine deficiency may increase oxalate excretion by 35%
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Rattus norvegicus
5739
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
rat
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
thiamine deficiency decreases specific activity
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-oxoglutarate + glyoxylate
-
395933
Rattus norvegicus
2-hydroxy-3-oxohexandioate + CO2
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
thiamine diphosphate
deficiency may lead to hyperoxaluria and glyoxylate excretion
Rattus norvegicus
Application (protein specific)
Application
Commentary
Organism
medicine
involved in renal stone formation, decreased activity due to thiamine deficiency may increase oxalate excretion by 35%
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
thiamine diphosphate
deficiency may lead to hyperoxaluria and glyoxylate excretion
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Rattus norvegicus
5739
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
thiamine deficiency decreases specific activity
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-oxoglutarate + glyoxylate
-
395933
Rattus norvegicus
2-hydroxy-3-oxohexandioate + CO2
-
-
-
-
Other publictions for EC 2.2.1.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Balakrishnan
Influence of allosteric regula ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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288
21688-21702
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736654
Patel
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Investigation of the donor and ...
Escherichia coli
J. Mol. Catal. B
98
42-45
2013
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708099
de Carvalho
Activity-based metabolomic pro ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Chem. Biol.
17
323-332
2010
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719051
Zhao
A protecting group-free synthe ...
Mycobacterium tuberculosis
Bioorg. Med. Chem. Lett.
20
6472-6474
2010
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657709
Dills
-
High pressure liquid chromatog ...
Bos taurus
Biochem. Arch.
15
279-284
1999
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395931
Rattan
Oxalate metabolism in magnesiu ...
Rattus norvegicus
Magnes. Res.
6
127-133
1993
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1
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395936
Bats
Investigations into the effect ...
Rattus norvegicus
Nephron
57
460-469
1991
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2
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395933
Sidhu
Oxalate metabolism in thiamine ...
Rattus norvegicus
Ann. Nutr. Metab.
31
354-361
1987
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1
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395924
O'Fallon
Cellular localization of alpha ...
Oryctolagus cuniculus, Rattus norvegicus
Biochim. Biophys. Acta
499
321-328
1977
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5
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4
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2
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2
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395925
Zaror-Behrens
-
Further studies on 2-oxoglutar ...
Tetrahymena pyriformis
Int. J. Biochem.
7
111-116
1976
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1
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1
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395926
Zaror-Behrens
Demonstration of 2-oxoglutarat ...
Tetrahymena pyriformis
Can. J. Biochem.
51
1505-1508
1973
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349030
Hirabayashi
-
Inhibition of the alpha-ketogl ...
Saccharomyces cerevisiae
Agric. Biol. Chem.
36
1249-1251
1972
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395935
Prather
-
Glycine and glyoxylate decarbo ...
Nicotiana rustica
Phytochemistry
11
1637-1647
1972
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395927
Yamasaki
Purification, general properti ...
Mycolicibacterium phlei
Biochim. Biophys. Acta
242
637-647
1971
-
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4
2
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2
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2
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1
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395928
Schlossberg
Carboligase activity of alpha- ...
Bos taurus, Rattus norvegicus
Biochemistry
9
1148-1153
1970
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395932
Yamasaki
alpha-Ketoglutarate:glyoxylate ...
Escherichia coli
Biochem. Biophys. Res. Commun.
39
790-795
1970
1
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395929
Schlossberg
Isolation and identification o ...
Bos taurus
Biochemistry
7
333-337
1968
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395930
Steward
The synergistic decarboxylatio ...
Sus scrofa
Biochem. J.
102
885-897
1967
3
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