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Information on EC 2.2.1.5 - 2-hydroxy-3-oxoadipate synthase

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IUBMB Comments
The bacterial enzyme requires thiamine diphosphate. The product decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
(R)-HOA synthase, 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), 2-hydroxy-3-oxoadipate synthase, 2-oxoglutarate: glyoxylate carboligase, alpha-ketoglutarate:glyoxylate carboligase, alpha-ketoglutaric-glyoxylic carboligase, carboligase, EC 4.1.3.15, glyoxylate-2-oxoglutarate carboligase, HOA synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2
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PATHWAY SOURCE
PATHWAYS
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