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Literature summary for 2.1.1.60 extracted from
- Purification and characterization of calmodulin (lysine 115) N-methyltransferase from Paramecium tetraurelia (1994), Biochim. Biophys. Acta, 1199, 183-194.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | absolute requirement | Paramecium tetraurelia |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Calmidazolium | - |
Paramecium tetraurelia | |
| Mellitin | - |
Paramecium tetraurelia | |
| additional information | not inhibitory: sinefungin, tubercidin, calmodulin antagonist W7 | Paramecium tetraurelia | |
| S-adenosylhomocysteine | - |
Paramecium tetraurelia | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
S-adenosyl-L-methionine | - |
Paramecium tetraurelia | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | stimulation | Paramecium tetraurelia | |
| Mg2+ | activation | Paramecium tetraurelia | |
| Mn2+ | stimulation | Paramecium tetraurelia | |
| additional information | not stimulating: Zn2+ | Paramecium tetraurelia | |
| Ni2+ | stimulation | Paramecium tetraurelia | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33000 | - |
gel filtration | Paramecium tetraurelia |
| 37000 | - |
1 * 37000, SDS-PAGE | Paramecium tetraurelia |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Paramecium tetraurelia | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Paramecium tetraurelia |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + calmodulin L-lysine | - |
Paramecium tetraurelia | S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine | trimethyllysine calmodulin, major product, + dimethyllysine + monomethyllysine | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 37000, SDS-PAGE | Paramecium tetraurelia |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Paramecium tetraurelia |
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