Literature summary for 1.14.14.56 extracted from

Duisken, M.; Sandner, F.; Bloemeke, B.; Hollender, J.
Metabolism of 1,8-cineole by human cytochrome P450 enzymes: identification of a new hydroxylated metabolite (2005), Biochim. Biophys. Acta, 1722, 304-311.

Search for more literature for 1.14.14.56

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.012	-	1,8-cineole	pH 7.4, 37°C, formation of 2-hydroxy-1,8-cineole by isoform CYP3A4	Homo sapiens
0.019	-	1,8-cineole	pH 7.4, 37°C, formation of 3-hydroxy-1,8-cineole by isoform CYP3A4	Homo sapiens
0.141	-	1,8-cineole	pH 7.4, 37°C, formation of 3-hydroxy-1,8-cineole by isoform CYP3A5	Homo sapiens
0.599	-	1,8-cineole	pH 7.4, 37°C, formation of 2-hydroxy-1,8-cineole by isoform CYP3A5	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2	-	Homo sapiens	2alpha-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2	-	Homo sapiens	3alpha-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP3A4	-	Homo sapiens
CYP3A5	-	Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
0.056	-	1,8-cineole	pH 7.4, 37°C, formation of 3-hydroxy-1,8-cineole by isoform CYP3A4	Homo sapiens
0.08	-	1,8-cineole	pH 7.4, 37°C, formation of 2-hydroxy-1,8-cineole by isoform CYP3A4	Homo sapiens

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Release 2023.1 (January 2023)