We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments A cytochrome P -450 (heme-thiolate) protein. The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf . EC 1.14.14.55 , quinine 3-monooxygenase, EC 1.14.14.57 , taurochenodeoxycholate 6-hydroxylase and EC 1.14.14.73 , albendazole monooxygenase (sulfoxide-forming).
Synonyms
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC 1.14.13.157
-
-
formerly
-
CYP3A4
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,8-cineole + [reduced NADPH-hemoprotein reductase] + O2 = 2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MetaCyc
1,8-cineole degradation
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,8-cineole,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (2-exo-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein. The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.14.55, quinine 3-monooxygenase, EC 1.14.14.57, taurochenodeoxycholate 6-hydroxylase and EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming).
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,4-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
2-exo-hydroxy-1,4-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
2alpha-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: -
?
1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
3alpha-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: -
?
1,4-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
2-exo-hydroxy-1,4-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: -
?
1,4-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
2-exo-hydroxy-1,4-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: -
?
1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: -
?
1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ketoconazole
-
significant inhibition
ketoconazole
-
significant inhibition
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(3beta,16alpha)-3-hydroxy-20-oxopregn-5-ene-16-carbonitrile
-
induces activity
dexamethasone
-
induces activity
Phenobarbital
-
induces activity
pregnenolone 16alpha-carbonitrile
-
induces activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.012 - 0.599
1,8-cineole
0.45
1,4-cineole
-
pH 7.4, 37Ā°C
1.033
1,4-cineole
-
pH 7.4, 37Ā°C, animals treated with pregnenolone 16alpha-carbonitrile
1.123
1,4-cineole
-
pH 7.4, 37Ā°C, animals treated with dexamethasone
0.012
1,8-cineole
-
pH 7.4, 37Ā°C, formation of 2-hydroxy-1,8-cineole by isoform CYP3A4
0.019
1,8-cineole
-
pH 7.4, 37Ā°C, formation of 3-hydroxy-1,8-cineole by isoform CYP3A4
0.02
1,8-cineole
-
pH 7.4, 37Ā°C, after treatment of animals with pregenolone-16alpha-carbonitrile
0.05
1,8-cineole
-
pH 7.4, 37Ā°C
0.141
1,8-cineole
-
pH 7.4, 37Ā°C, formation of 3-hydroxy-1,8-cineole by isoform CYP3A5
0.599
1,8-cineole
-
pH 7.4, 37Ā°C, formation of 2-hydroxy-1,8-cineole by isoform CYP3A5
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.056
1,8-cineole
-
pH 7.4, 37Ā°C, formation of 3-hydroxy-1,8-cineole by isoform CYP3A4
0.08
1,8-cineole
-
pH 7.4, 37Ā°C, formation of 2-hydroxy-1,8-cineole by isoform CYP3A4
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
physiological function
-
CYP3A4 is a major enzyme involved in the oxidation of 1,8-cineole by human liver microsomes, as there is a good correlation between CYP3A4 contents and 1,8-cineole 2-hydroxylation activities in liver microsomes of eighteen human samples and of various recombinant human P450 enzymes examined, CYP3A4 has the highest activities for 1,8-cineole 2-hydroxylation
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CP3A4_HUMAN
503
2
57343
Swiss-Prot
Secretory Pathway (Reliability: 1 ), Mitochondrion (Reliability: 4 )
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in Escherichia coli
-
expression in insect cells
expression in insect cells
-
expression in insect cells
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Duisken, M.; Sandner, F.; Bloemeke, B.; Hollender, J.
Metabolism of 1,8-cineole by human cytochrome P450 enzymes: identification of a new hydroxylated metabolite
Biochim. Biophys. Acta
1722
304-311
2005
Homo sapiens
brenda
Miyazawa, M.; Shindo, M.; Shimada, T.
Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from Eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes
Drug Metab. Dispos.
29
200-205
2001
Rattus norvegicus
brenda
Miyazawa, M.; Shindo, M.; Shimada, T.
Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes
Xenobiotica
31
713-723
2001
Homo sapiens, Rattus norvegicus
brenda
html completed
show
top
