Literature summary for 1.14.14.169 extracted from

Frey, M.; Schmauder, K.; Pateraki, I.; Spring, O.
Biosynthesis of eupatolide-A metabolic route for sesquiterpene lactone formation involving the P450 enzyme CYP71DD6 (2018), ACS Chem. Biol., 13, 1536-1543 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2	Helianthus annuus	overall reaction. The product 6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate spontaneously lactonizes to eupatolide	eupatolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Helianthus annuus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2	overall reaction. The product 6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate spontaneously lactonizes to eupatolide	Helianthus annuus	eupatolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O	-	?
8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2	6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate spontaneously lactonizes to eupatolide	Helianthus annuus	6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP71DD6	-	Helianthus annuus
HaES	-	Helianthus annuus

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome P-450	heme-thiolate protein	Helianthus annuus

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Release 2023.1 (January 2023)