Inhibitors | Comment | Organism | Structure |
---|---|---|---|
clomiphene | interacts with heme, is less potent than azoles | Mycobacterium tuberculosis | |
fluconazole | - |
Mycobacterium tuberculosis | |
glafenine | interacts with heme, shows no potency which may arise from its hydrophilic nature which lower its up-take and capacity to reach the target enzyme | Mycobacterium tuberculosis | |
ketoconazole | residues lining the ketoconazole pocket include Ala397 and Ala398, Arg389 and Arg393, Asp377, Glu308, Gly390, Ile401, Leu311 and Leu315, Lys312, Phe387, Pro386, Trp382 and Trp384 | Mycobacterium tuberculosis | |
miconazole | - |
Mycobacterium tuberculosis | |
additional information | the aromatic moieties of drugs where aligning to phenylalanine and tyrosine residues that lines the hydrophobic part of the binding pocket which is itself generally hydrophobic | Mycobacterium tuberculosis | |
N-{2-[4-(acetylamino)phenyl]ethyl}-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide | interacts with heme | Mycobacterium tuberculosis | |
rottlerin | interacts with heme | Mycobacterium tuberculosis | |
SPSM1 | interacts with heme | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WPP9 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WPP9 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
14alpha-lanosterol demethylase | - |
Mycobacterium tuberculosis |
CYP51 | - |
Mycobacterium tuberculosis |