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Information on EC 1.14.14.154 - sterol 14alpha-demethylase

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IUBMB Comments
This cytochrome P-450 (heme-thiolate) enzyme acts on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyses a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
14-alpha sterol demethylase, 14-demethylase, 14alpha-demethylase, 14alpha-lanosterol demethylase, 14alpha-methylsterol 14alpha-demethylase, 14alpha-sterol demethylase, 14DM, AF_14DM, C- I4 demethylase, CACYP51, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 14alpha-formylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a DELTA14-steroid + formate + [oxidized NADPH-hemoprotein reductase] + H2O
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(1c)
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a 14alpha-hydroxymethylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a 14alpha-formylsteroid + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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(1b)
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a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
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a 14alpha-methylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a 14alpha-hydroxymethylsteroid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1a)
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