Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzodiazepine | - |
Bos taurus | |
Sodium barbitone | - |
Bos taurus | |
Sodium barbitone | - |
Sus scrofa | |
sodium valproate | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
NADPH | AR1 | Bos taurus | |
0.003 | - |
NADPH | G2 | Bos taurus | |
0.007 | - |
NADPH | AR4 | Bos taurus | |
0.008 | - |
NADPH | AR3 | Bos taurus | |
0.008 | - |
3-Pyridinecarboxaldehyde | AR3 | Bos taurus | |
0.0084 | - |
p-nitrobenzaldehyde | AR3 | Bos taurus | |
0.009 | - |
menadione | AR4 | Bos taurus | |
0.018 | - |
p-Carboxybenzaldehyde | AR1 | Bos taurus | |
0.028 | - |
Succinic semialdehyde | AR4 | Bos taurus | |
0.029 | - |
Succinic semialdehyde | AR1 | Bos taurus | |
0.03 | - |
menadione | G2 | Bos taurus | |
0.036 | - |
Succinic semialdehyde | G2 | Bos taurus | |
0.064 | - |
Succinic semialdehyde | AR3 | Bos taurus | |
0.071 | - |
p-nitrobenzaldehyde | AR1 | Bos taurus | |
0.129 | - |
p-nitrobenzaldehyde | G2 | Bos taurus | |
0.258 | - |
p-Carboxybenzaldehyde | AR3 | Bos taurus | |
0.262 | - |
p-nitrobenzaldehyde | AR4 | Bos taurus | |
0.751 | - |
3-Pyridinecarboxaldehyde | G2 | Bos taurus | |
0.934 | - |
3-Pyridinecarboxaldehyde | AR1 | Bos taurus | |
1.18 | - |
cyclohexanone | G2 | Bos taurus | |
1.29 | - |
D-glucuronic acid | AR1 | Bos taurus | |
2.48 | - |
D-glucuronic acid | G2 | Bos taurus | |
2.99 | - |
D-glucuronic acid | AR3 | Bos taurus | |
5 | - |
3-Pyridinecarboxaldehyde | AR4 | Bos taurus | |
36.77 | - |
cyclohexanone | AR4 | Bos taurus | |
41 | - |
xylose | AR3 | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Bos taurus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25500 | - |
G2, gel filtration | Bos taurus |
26300 | - |
gel filtration | Bos taurus |
30000 | - |
- |
Sus scrofa |
30000 | - |
AR1, gel filtration | Bos taurus |
31000 | - |
AR3, gel filtration | Bos taurus |
33500 | - |
1 * 33500, AR1, SDS-PAGE | Bos taurus |
34700 | - |
1 * 34700, AR3, SDS-PAGE | Bos taurus |
56000 | - |
AR4, gel filtration | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | Cavia porcellus | - |
L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | Sus scrofa | - |
L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | Bos taurus | - |
L-gulonate + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Cavia porcellus | - |
glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Sus scrofa | - |
glycerol + NADP+ | - |
r | |
L-glyceraldehyde + NADPH | Cavia porcellus | - |
glycerol + NADP+ | - |
r | |
L-glyceraldehyde + NADPH | Sus scrofa | - |
glycerol + NADP+ | - |
r | |
L-gulonic acid + NADP+ | Sus scrofa | - |
D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADP+ | Bos taurus | - |
D-glucuronic acid + NADPH | - |
r | |
succinic semialdehyde + NADPH + H+ | Sus scrofa | - |
4-hydroxybutyrate + NADP+ | - |
r | |
succinic semialdehyde + NADPH + H+ | Bos taurus | - |
4-hydroxybutyrate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
ox | - |
Cavia porcellus | - |
guinea pig | - |
Sus scrofa | - |
pig | - |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Cavia porcellus | - |
brain | - |
Sus scrofa | - |
brain | - |
Bos taurus | - |
kidney | - |
Cavia porcellus | - |
kidney | - |
Sus scrofa | - |
kidney | - |
Bos taurus | - |
liver | - |
Cavia porcellus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.55 | - |
AR3 | Bos taurus |
8.94 | - |
AR1 | Bos taurus |
Storage Stability | Organism |
---|---|
-20°C AR1 stable for at least 6 months | Bos taurus |
-20°C AR3 loses most of its activity | Bos taurus |
4°C AR1 loses all activity after storage for 1 month | Bos taurus |
4°C AR3 stable for at least 1 month in presence of NaN3 | Bos taurus |
4°C in 0.01% NaN3 stable for at least 1 month, the gel-filtered enzyme is stable for approximately 2 weeks | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-pyridinecarboxaldehyde + NADPH | - |
Cavia porcellus | 3-pyridinemethanol + NADP+ | - |
r | |
3-pyridinecarboxaldehyde + NADPH | - |
Sus scrofa | 3-pyridinemethanol + NADP+ | - |
r | |
3-pyridinecarboxaldehyde + NADPH | AR3 | Bos taurus | 3-pyridinemethanol + NADP+ | - |
? | |
cyclohexanol + NADP+ | - |
Bos taurus | cyclohexanone + NADPH + H+ | - |
r | |
cyclohexanone + NADPH | - |
Sus scrofa | cyclohexanol + NADP+ | - |
? | |
cyclohexanone + NADPH | G2 | Bos taurus | cyclohexanol + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Cavia porcellus | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Cavia porcellus | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Sus scrofa | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Sus scrofa | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | AR1 | Bos taurus | L-gulonate + NADP+ | - |
? | |
D-glyceraldehyde + NADPH + H+ | - |
Cavia porcellus | glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Sus scrofa | glycerol + NADP+ | - |
r | |
D-xylose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
D-xylose + NADPH | AR3 | Bos taurus | ? + NADP+ | - |
? | |
L-glyceraldehyde + NADPH | - |
Cavia porcellus | glycerol + NADP+ | - |
r | |
L-glyceraldehyde + NADPH | - |
Sus scrofa | glycerol + NADP+ | - |
r | |
L-gulonic acid + NADP+ | - |
Sus scrofa | D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADP+ | - |
Bos taurus | D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADPH | - |
Sus scrofa | D-glucuronic acid + NADP+ | - |
r | |
L-gulonic acid + NADPH | - |
Bos taurus | D-glucuronic acid + NADP+ | - |
r | |
menadione + NADPH | G2 | Bos taurus | ? + NADP+ | - |
? | |
additional information | - |
Sus scrofa | ? | - |
? | |
additional information | AR1 is not active with neutral sugars or with ketones, AR3 is capable of reducing neutral sugars, G2 is active with ketones, AR4 is inactive with 15-oxoprostaglandin B1 | Bos taurus | ? | - |
? | |
p-carboxybenzaldehyde + NADPH | - |
Sus scrofa | p-carboxybenzyl alcohol + NADP+ | - |
r | |
p-carboxybenzaldehyde + NADPH | AR1 | Bos taurus | p-carboxybenzyl alcohol + NADP+ | - |
r | |
p-nitrobenzaldehyde + NADPH | - |
Sus scrofa | p-nitrobenzylalcohol + NADP+ | - |
r | |
p-nitrobenzaldehyde + NADPH | AR1 | Bos taurus | p-nitrobenzylalcohol + NADP+ | - |
r | |
propane-1,2-diol + NADP+ | - |
Sus scrofa | lactaldehyde + NADPH | - |
r | |
propane-1,2-diol + NADP+ | - |
Bos taurus | lactaldehyde + NADPH | - |
r | |
succinic semialdehyde + NADPH + H+ | - |
Sus scrofa | 4-hydroxybutyrate + NADP+ | - |
r | |
succinic semialdehyde + NADPH + H+ | - |
Bos taurus | 4-hydroxybutyrate + NADP+ | - |
r | |
succinic semialdehyde + NADPH + H+ | AR1 | Bos taurus | 4-hydroxybutyrate + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Sus scrofa |
monomer | 1 * 33500, AR1, SDS-PAGE | Bos taurus |
monomer | 1 * 34700, AR3, SDS-PAGE | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
aldehyde/ketone reductase | - |
Cavia porcellus |
hexogenate dehydrogenase | - |
Bos taurus |