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Information on EC 5.5.1.23 - aklanonic acid methyl ester cyclase

for references in articles please use BRENDA:EC5.5.1.23
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IUBMB Comments
The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin.
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Word Map
  • 5.5.1.23
  • desaturase
  • arachidonic
  • delta6-desaturase
  • polyunsaturated
  • delta5
  • alpha-linolenic
  • b5-like
  • histidine-rich
  • di-homo-gamma-linolenic
  • daunomycin
  • desaturation
  • alpina
  • oleic
  • delta5-desaturation
  • polyketide
  • mortierella
The expected taxonomic range for this enzyme is: Streptomyces
Synonyms
AAME cyclase, AAMEcyclase, AcmA, AknH, DauD, DnrD, methyl aklanonate cyclase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
aklaviketone = methyl aklanonate
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