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IUBMB Comments The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
5.5.1.23
desaturase
arachidonic
delta6-desaturase
polyunsaturated
delta5
alpha-linolenic
b5-like
histidine-rich
di-homo-gamma-linolenic
daunomycin
desaturation
alpina
oleic
delta5-desaturation
polyketide
mortierella
Synonyms aklanonic acid methyl ester cyclase, more
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methyl aklanonate cyclase
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AcmA
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AknH
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aklaviketone = methyl aklanonate
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MetaCyc
aclacinomycin biosynthesis, daunorubicin biosynthesis
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aklaviketone lyase (decyclizing)
The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin.
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methyl aklanonate
aklaviketone
methyl aklanonate
aklaviketone
Substrates: - Products: enzyme is responsible for closing the last ring of the aclacinomycin aglycone moiety
?
methyl aklanonate
aklaviketone
Substrates: - Products: enzyme is responsible for closing the last ring of the aclacinomycin aglycone moiety
?
methyl aklanonate
aklaviketone
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Substrates: - Products: -
?
methyl aklanonate
aklaviketone
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Substrates: base-catalyzed mechanism Products: -
?
methyl aklanonate
aklaviketone
Substrates: - Products: -
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methyl aklanonate
aklaviketone
Substrates: the enzyme is involved in the biosynthesis of the anthracycline daunorubicin Products: -
?
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methyl aklanonate
aklaviketone
methyl aklanonate
aklaviketone
Substrates: - Products: enzyme is responsible for closing the last ring of the aclacinomycin aglycone moiety
?
methyl aklanonate
aklaviketone
Substrates: - Products: enzyme is responsible for closing the last ring of the aclacinomycin aglycone moiety
?
methyl aklanonate
aklaviketone
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Substrates: - Products: -
?
methyl aklanonate
aklaviketone
Substrates: the enzyme is involved in the biosynthesis of the anthracycline daunorubicin Products: -
?
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additional information
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enzyme activity is not accelerated or significantly inhibited by divalent metal ions (Zn2+, Co2+, Fe2+, Cu2+, or Mn2+) or chelating reagents
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additional information
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enzyme activity is not accelerated or significantly inhibited by divalent metal ions (Zn2+, Co2+, Fe2+, Cu2+, or Mn2+) or chelating reagents
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0.0521
methyl aklanonate
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pH 7.0, 30°C
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6 - 7.5
AAME cyclase activity is observed at both pH 7.5 and pH 6.0, suggesting that it has a broad optimal pH range for activity
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6.5 - 9
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pH 6.5: about 65% of maximal activity, 9.0: about 30% of maximal activity
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UniProt
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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physiological function
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the enzyme is involved in biosynthesis of aklaviketone, an intermediate in the biosynthetic pathway to daunorubicin and doxorubicin
physiological function
the enzyme is involved in the biosynthesis of the anthracycline daunorubicin
physiological function
enzyme is part of the akn gene cluster needed for aklavinone biosynthesis. It is responsible for closing the last ring of the aclacinomycin aglycone moiety
physiological function
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enzyme is part of the akn gene cluster needed for aklavinone biosynthesis. It is responsible for closing the last ring of the aclacinomycin aglycone moiety
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DNRD_STRGJ
144
0
16731
Swiss-Prot
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DNRD_STRPE
145
0
16701
Swiss-Prot
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DNRD_STRS5
161
0
18495
Swiss-Prot
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A0A399FDM3_9DEIN
172
1
18960
TrEMBL
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A0A654ADE6_9MICC
137
0
15191
TrEMBL
-
A0A2H5YTY4_9BACT
145
0
15979
TrEMBL
-
A0A163S8Q6_9CELL
177
0
18716
TrEMBL
-
A0A7W4ZTC7_9ACTN
145
0
16721
TrEMBL
-
A0A7Y9XH04_9ACTN
144
0
16736
TrEMBL
-
A0A7K0DRJ9_9NOCA
Nocardia aurantia
151
0
16459
TrEMBL
-
A0A1S9CVL2_9GAMM
142
0
15666
TrEMBL
-
A0A2P8AVL4_9ACTN
165
0
17678
TrEMBL
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A0A1J5PCH4_9ZZZZ
139
0
16027
TrEMBL
other Location (Reliability: 1 )
A0A1U7CPB2_9BACT
136
0
14960
TrEMBL
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A0A3G8JKL0_9ACTN
175
0
19379
TrEMBL
-
A0A7W9LZV1_9PSEU
145
0
16740
TrEMBL
-
A0A2W1JPY6_9CYAN
Acaryochloris thomasi RCC1774
164
0
18128
TrEMBL
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A0A2H5UYL5_9ARCH
135
0
15281
TrEMBL
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A0A679JR85_9HYPH
170
0
18873
TrEMBL
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16000
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x * 16000, SDS-PAGE
16572
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x * 16572, electrospray MS analysis
18495
x * 18495, calculated from sequence
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?
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x * 16000, SDS-PAGE
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x * 16572, electrospray MS analysis
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x * 18495, calculated from sequence
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overexpressed in Escherichia coli
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Kendrew, S.G.; Katayama, K.; Deutsch, E.; Madduri, K.; Hutchinson, C.R.
DnrD cyclase involved in the biosynthesis of doxorubicin: purification and characterization of the recombinant enzyme
Biochemistry
38
4794-4799
1999
Streptomyces peucetius
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Dickens, M.L.; Ye, J.; Strohl, W.R.
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5
J. Bacteriol.
177
536-543
1995
Streptomyces sp. (Q55215)
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Rty, K.; Kantola, J.; Hautala, A.; Hakala, J.; Ylihonko, K.; Mntsl, P.
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster
Gene
293
115-122
2002
Streptomyces galilaeus (O52646), Streptomyces galilaeus, Streptomyces galilaeus ATCC 31615 (O52646)
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