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Information on EC 5.3.99.7 - styrene-oxide isomerase
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5.3.99.7 styrene-oxide isomeraseIUBMB Comments
Highly specific.
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Word Map
- 5.3.99.7
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silicon-on-insulator
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fabric
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silicon
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waveguide
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photon
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wafer
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grate
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coupler
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grating
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spin-orbit
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bandwidth
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etch
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homeless
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semiconductor
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lithography
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nanowire
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monolith
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mach-zehnder
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transistor
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bragg
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interferometer
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on-chip
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toronto
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nanophotonic
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reflector
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adiabatic
- phenylacetaldehyde
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metal-oxide-semiconductor
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photodetectors
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splitter
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microring
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clad
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single-mode
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field-effect
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epitaxial
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heater
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diagnosis-related
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micromachined
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piezoresistive
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sub-wavelength
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winnipeg
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finite-difference
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foundry
- synthesis
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c-band
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telecommunication
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heterostructures
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low-loss
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lasing
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germanium
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all-optical
The enzyme appears in viruses and cellular organisms
Synonyms
soi, styrene oxide isomerase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
isomerase, styrene oxide
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-
-
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SOI
SOOI
StyC
styrene oxide isomerase
SOI
-
-
-
-
styrene oxide isomerase
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
styrene oxide = phenylacetaldehyde
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
intramolecular oxidoreduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
styrene-oxide isomerase (epoxide-cleaving)
Highly specific.
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CAS REGISTRY NUMBER
COMMENTARY
124541-89-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R,S)-4-chlorostyrene oxide
4-chlorophenylacetaldehyde
-
low activity
-
-
?
6,6a-dihydro-1aH-indeno[1,2-b]oxirene
1,3-dihydro-2H-inden-2-one
-
45% of the activity with 2-phenyloxirane
-
-
?
(R)-styrene oxide
phenylacetaldehyde
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45% of activity compared to (S)-styrene oxide and (R,S)-styrene oxide
-
-
?
(R)-styrene oxide
phenylacetaldehyde
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45% of activity compared to (S)-styrene oxide and (R,S)-styrene oxide
-
-
?
(R,S)-4-bromostyrene oxide
4-bromophenylacetaldehyde
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low activity
-
-
?
1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene
3,4-dihydronaphthalen-2(1H)-one
-
0.5% of the activity with 2-phenyloxirane
-
-
?
1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene
3,4-dihydronaphthalen-2(1H)-one
-
0.5% of the activity with 2-phenyloxirane
-
-
?
2-(4-chlorophenyl)oxirane
(4-chlorophenyl)acetaldehyde
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3.7% of the activity with 2-phenyloxirane
-
-
?
2-(4-chlorophenyl)oxirane
(4-chlorophenyl)acetaldehyde
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3.7% of the activity with 2-phenyloxirane
-
-
?
2-(4-methylphenyl)oxirane
(4-methylphenyl)acetaldehyde
-
113% of the activity with 2-phenyloxirane
-
-
?
2-(4-methylphenyl)oxirane
(4-methylphenyl)acetaldehyde
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113% of the activity with 2-phenyloxirane
-
-
?
2-ethyl-2-phenyloxirane
2-phenylbutanal
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7.6% of the activity with 2-phenyloxirane
-
-
?
2-ethyl-2-phenyloxirane
2-phenylbutanal
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7.6% of the activity with 2-phenyloxirane
-
-
?
2-methyl-2-phenyloxirane
hydratropaldehyde
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15% of the activity with 2-phenyloxirane
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-
?
2-methyl-2-phenyloxirane
hydratropaldehyde
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15% of the activity with 2-phenyloxirane
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-
?
styrene oxide + H2O
phenylacetaldehyde
aerobic bacterium (strain S5)
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enzyme is involved in the pathway of styrene degradation
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?
styrene oxide + H2O
phenylacetaldehyde
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compared with the (R)-isomer, the relative activity of the enzyme towards (R)-styrene oxide is 51% of that for the (S)-isomer
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-
?
styrene oxide + H2O
phenylacetaldehyde
-
key enzyme of styrene and styrene oxide metabolism
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-
ir
styrene oxide + H2O
phenylacetaldehyde
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compared with the (R)-isomer, the relative activity of the enzyme towards (R)-styrene oxide is 51% of that for the (S)-isomer
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-
?
styrene oxide + H2O
phenylacetaldehyde
-
key enzyme of styrene and styrene oxide metabolism
-
-
ir
styrene oxide + H2O
phenylacetaldehyde
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enzyme is involved in the pathway of styrene degradation
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?
styrene oxide + H2O
phenylacetaldehyde
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styrene, styrene oxide, and phenylacetaldehyde induce the enzymes involved in the degradation of styrene to phenylacetic acid, glucose has no effect
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-
?
styrene oxide + H2O
phenylacetaldehyde
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enzyme is involved in the pathway of styrene degradation
-
?
styrene oxide + H2O
phenylacetaldehyde
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styrene, styrene oxide, and phenylacetaldehyde induce the enzymes involved in the degradation of styrene to phenylacetic acid, glucose has no effect
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-
?
styrene oxide + H2O
phenylacetaldehyde
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equilibrium constant favors phenylacetaldehyde formation
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r
styrene oxide + H2O
phenylacetaldehyde
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equilibrium constant favors phenylacetaldehyde formation
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r
additional information
?
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the enzyme shows the ability to convert a spectrum of substituted styrene oxides
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?
additional information
?
-
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the enzyme shows the ability to convert a spectrum of substituted styrene oxides
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
styrene oxide + H2O
phenylacetaldehyde
aerobic bacterium (strain S5)
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enzyme is involved in the pathway of styrene degradation
-
?
styrene oxide + H2O
phenylacetaldehyde
-
key enzyme of styrene and styrene oxide metabolism
-
-
ir
styrene oxide + H2O
phenylacetaldehyde
-
key enzyme of styrene and styrene oxide metabolism
-
-
ir
styrene oxide + H2O
phenylacetaldehyde
-
enzyme is involved in the pathway of styrene degradation
-
?
styrene oxide + H2O
phenylacetaldehyde
-
styrene, styrene oxide, and phenylacetaldehyde induce the enzymes involved in the degradation of styrene to phenylacetic acid, glucose has no effect
-
-
?
styrene oxide + H2O
phenylacetaldehyde
-
enzyme is involved in the pathway of styrene degradation
-
?
styrene oxide + H2O
phenylacetaldehyde
-
styrene, styrene oxide, and phenylacetaldehyde induce the enzymes involved in the degradation of styrene to phenylacetic acid, glucose has no effect
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
phenylacetaldehyde
-
irreversible product inhibition, half-life of 15 min determined at a phenylacetaldehyde concentration of about 55 mM
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5 - 10
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pH 5.0-7.5: maximal activity, pH 10.0: about 50% of maximal activity
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene styC, strain ST-5 has a gene cluster containing four open reading frames which encode styrene degradation enzymes
UniProt
brenda
gene styC, strain ST-5 has a gene cluster containing four open reading frames which encode styrene degradation enzymes
UniProt
brenda
strain AC-5 and strain ST-5. Strain ST-10 does not have a styrene oxide isoemrase and metabolized styrene oxide by an unknown enzymatic reaction
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-
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
additional information
additional information
-
not membrane-bound, probably bound to the cell wall
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brenda
additional information
-
not membrane-bound, probably bound to the cell wall
-
-
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
additional information
metabolism
the enzyme is involved in the styrene degradation pathway, overview
metabolism
-
the enzyme is part of the upper pathway of styrene degradation via side chain oxygenation
metabolism
-
the enzyme is involved in the styrene degradation pathway, overview
-
metabolism
-
the enzyme is part of the upper pathway of styrene degradation via side chain oxygenation
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additional information
in strain ST-10, which lacks a styrene oxide isomerase, styrene oxide is converted to phenylacetaldehyde by spontaneous chemical reaction. The strain accumulates styrene oxide as a metabolic intermediate. The produced phenylacetaldehyde is converted to phenylacetic acid in strain ST-10 as well as in strain ST-5
additional information
-
in strain ST-10, which lacks a styrene oxide isomerase, styrene oxide is converted to phenylacetaldehyde by spontaneous chemical reaction. The strain accumulates styrene oxide as a metabolic intermediate. The produced phenylacetaldehyde is converted to phenylacetic acid in strain ST-10 as well as in strain ST-5
additional information
-
in strain ST-10, which lacks a styrene oxide isomerase, styrene oxide is converted to phenylacetaldehyde by spontaneous chemical reaction. The strain accumulates styrene oxide as a metabolic intermediate. The produced phenylacetaldehyde is converted to phenylacetic acid in strain ST-10 as well as in strain ST-5
-
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A0A6P2HNG6_BURL3
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
153
3
16697
TrEMBL
-
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
enzyme disruption mutant is unable to grow on styrene or styrene oxide and accumulates enantiopure (S)-styrene when incubated with styrene. Upon growth on citrate as carbon source, mutant strain exhibits a high whole-cell activity of styrene oxide formation
additional information
-
enzyme disruption mutant is unable to grow on styrene or styrene oxide and accumulates enantiopure (S)-styrene when incubated with styrene. Upon growth on citrate as carbon source, mutant strain exhibits a high whole-cell activity of styrene oxide formation
-
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, 50 mM potassium phosphate buffer, pH 7.0, 30% loss of activity after 2 weeks
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
native enzyme partially from styrene-grown cells by membrane preparation and solubilization
-
partial purification
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CLONED (Commentary)