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Information on EC 4.99.1.3 - sirohydrochlorin cobaltochelatase

for references in articles please use BRENDA:EC4.99.1.3

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IUBMB Comments

This enzyme, which forms part of the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway, is an ATP-independent type II chelatase. Two distinct forms are known - a primordial form named CbiX, which is most common in archaea, and a strictly bacterial form named CbiK. See EC 6.6.1.2, cobaltochelatase, for the cobaltochelatase that participates in the aerobic cobalamin biosynthesis pathway.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
cobalt chelatase, cbixl, cbixs, sirohydrochlorin-ferrochelatase, sirohydrochlorin cobaltochelatase, anaerobic cobalt chelatase, archaeal cobaltochelatase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cobalt-sirohydrochlorin + 2 H+ = sirohydrochlorin + Co2+
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PATHWAY SOURCE
PATHWAYS
MetaCyc
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
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