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IUBMB CommentsThe enzyme, characterized from the gut bacteria Bacteroides thetaiotaomicron and Bacteroides xylanisolvens, can also catalyse the reaction of EC 3.2.1.130, glycoprotein endo-alpha-1,2-mannosidase.
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alpha-mannan 1,2-[alpha-D-mannosyl-(1->3)-alpha-D-mannose] hydrolase
The enzyme, characterized from the gut bacteria Bacteroides thetaiotaomicron and Bacteroides xylanisolvens, can also catalyse the reaction of EC 3.2.1.130, glycoprotein endo-alpha-1,2-mannosidase.
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4-methylumbelliferyl (alpha-D-glucopyranosyl)-(1->3)-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + (alpha-D-glucopyranosyl)-(1->3)-alpha-D-mannopyranoside
4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside
methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranoside + H2O
alpha-1,3-mannobiose + methyl alpha-1,2-mannobioside
methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranoside + H2O
alpha-1,3-mannobiose + methyl alpha-1,2-mannobioside
additional information
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4-methylumbelliferyl (alpha-D-glucopyranosyl)-(1->3)-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + (alpha-D-glucopyranosyl)-(1->3)-alpha-D-mannopyranoside
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4-methylumbelliferyl (alpha-D-glucopyranosyl)-(1->3)-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + (alpha-D-glucopyranosyl)-(1->3)-alpha-D-mannopyranoside
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4-methylumbelliferyl (alpha-D-glucopyranosyl)-(1->3)-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + (alpha-D-glucopyranosyl)-(1->3)-alpha-D-mannopyranoside
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4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside
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4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside
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4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside + H2O
4-methylumbelliferone + (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside
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methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranoside + H2O
alpha-1,3-mannobiose + methyl alpha-1,2-mannobioside
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methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranoside + H2O
alpha-1,3-mannobiose + methyl alpha-1,2-mannobioside
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methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranoside + H2O
alpha-1,3-mannobiose + methyl alpha-1,2-mannobioside
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methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranoside + H2O
alpha-1,3-mannobiose + methyl alpha-1,2-mannobioside
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methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranoside + H2O
alpha-1,3-mannobiose + methyl alpha-1,2-mannobioside
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additional information
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enzyme additionally catalyzes the reaction of EC 3.2.1.130, glycoprotein endo-alpha-1,2-mannosidase. The enzyme shows an approximate 5 kJ/mol preference for mannose-configured substrates in the -2 subsite relative to glucose
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additional information
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enzyme additionally catalyzes the reaction of EC 3.2.1.130, glycoprotein endo-alpha-1,2-mannosidase. The enzyme shows an approximate 5 kJ/mol preference for mannose-configured substrates in the -2 subsite relative to glucose
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additional information
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enzyme additionally catalyzes the reaction of EC 3.2.1.130, glycoprotein endo-alpha-1,2-mannosidase. The enzyme shows an approximate 5 kJ/mol preference for mannose-configured substrates in the -2 subsite relative to glucose
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0.038 - 1.83
4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside
0.404 - 2.6
methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranoside
0.038
4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside
pH 7, 37°C
1.83
4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside
pH 7, 37°C
0.404
methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranoside
pH 7, 37°C
2.6
methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranoside
pH 7, 37°C
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0.00062 - 0.0085
4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside
0.0021 - 1.15
methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranoside
0.00062
4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside
pH 7, 37°C
0.0085
4-methylumbelliferyl (alpha-D-mannopyranosyl)-(1->3)-alpha-D-mannopyranoside
pH 7, 37°C
0.0021
methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranoside
pH 7, 37°C
1.15
methyl alpha-D-mannopyranosyl-(1->3)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranoside
pH 7, 37°C
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physiological function
endo-alpha-1,2-mannosidase BT3862 releases a limited proportion of the terminal Man-alpha-1,3-Man disaccharides of yeast mannan, thereby assisting in exposing the backbone to other mannosidases
physiological function
enzyme releases alpha-1,3-mannobiose by hydrolyzing alphaMan-1,3-aMan->1,2-alphaMan-1,2-alphaMan sequences within branches off the main alpha-1,6-mannan backbone of fungal cell walls
physiological function
enzyme releases alpha-1,3-mannobiose by hydrolyzing alphaMan-1,3-aMan->1,2-alphaMan-1,2-alphaMan sequences within branches off the main alpha-1,6-mannan backbone of fungal cell walls
physiological function
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endo-alpha-1,2-mannosidase BT3862 releases a limited proportion of the terminal Man-alpha-1,3-Man disaccharides of yeast mannan, thereby assisting in exposing the backbone to other mannosidases
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physiological function
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enzyme releases alpha-1,3-mannobiose by hydrolyzing alphaMan-1,3-aMan->1,2-alphaMan-1,2-alphaMan sequences within branches off the main alpha-1,6-mannan backbone of fungal cell walls
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Hakki, Z.; Thompson, A.J.; Bellmaine, S.; Speciale, G.; Davies, G.J.; Williams, S.J.
Structural and kinetic dissection of the endo-alpha-1,2-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp.
Chemistry
21
1966-1977
2015
Bacteroides xylanisolvens (D6D1V7), Bacteroides thetaiotaomicron (Q8A109), Bacteroides thetaiotaomicron DSM 2079 (Q8A109)
brenda
Cuskin, F.; Lowe, E.; Temple, M.; Zhu, Y.; Cameron, E.; Pudlo, N.; Porter, N.; Urs, K.; Thompson, A.; Cartmell, A.; Rogowski, A.; Hamilton, B.; Chen, R.; Tolbert, T.; Piens, K.; Bracke, D.; Vervecken, W.; Hakki, Z.; Speciale, G.; Munoz-Munoz, J.; Day, A.;
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
Nature
517
165-169
2015
Bacteroides thetaiotaomicron (Q8A109), Bacteroides thetaiotaomicron DSM 2079 (Q8A109)
brenda
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History
Enzyme Nomenclature
3.2.1.198 alpha-mannan endo-1,2-alpha-mannanase
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