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Information on EC - L-seryl-tRNASec selenium transferase

for references in articles please use BRENDA:EC2.9.1.1
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IUBMB Comments
A pyridoxal 5'-phosphate enzyme identified in Escherichia coli. Recognises specifically tRNASec-species. Binding of tRNASec also occurs in the absence of the seryl group. 2-Aminoacryloyl-tRNA, bound to the enzyme as an imine with the pyridoxal phosphate, is an intermediate in the reaction. Since the selenium atom replaces oxygen in serine, the product may also be referred to as L-selenoseryl-tRNASec. The symbol Sel has also been used for selenocysteine but Sec is preferred.
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Word Map
  • autoantibodies
  • selenoproteins
  • antinuclear
  • anti-sla
  • antimitochondrial
  • sepsecs
  • selenocysteyl-trnasec
  • secis
  • trnasersec
  • anti-liver
  • selenocysteine-containing
  • trnaser
  • anti-lkm1
  • liver-pancreas
  • anti-smooth
  • ser-trnasec
  • non-organ
  • selenoproteome
The enzyme appears in viruses and cellular organisms
soluble liver antigen, selenocysteine synthase, sec synthase, selenocysteinyl-trna synthase, more
L-seryl-tRNASec + selenophosphate = L-selenocysteinyl-tRNASec + phosphate
show the reaction diagram
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