Cloned (Comment) | Organism |
---|---|
gene secS, DNA and amino acid sequence determination and analysis | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mus musculus | - |
- |
soluble | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
48000 | - |
x * 48000, SDS-PAGE | Mus musculus |
48000 | - |
x * 48000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-seryl-tRNASec + selenophosphate | Mus musculus | sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
L-seryl-tRNASec + selenophosphate | Homo sapiens | sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
additional information | Homo sapiens | SecS occurs in patients with autoimmune chronic hepatitis as an autoimmune factor that co-precipitated tRNA[Ser]Sec in cell extracts of these individuals andis known as the SLA, soluble liver antigen | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-seryl-tRNASec + selenophosphate | - |
Homo sapiens | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
L-seryl-tRNASec + selenophosphate | sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview | Mus musculus | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
L-seryl-tRNASec + selenophosphate | sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview | Homo sapiens | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
L-seryl-tRNASec + selenophosphate | the efficiency of tRNA binding in descending order is O-phosphoseryl-tRNA[Ser]Sec, tRNA[Ser]Sec, and seryl-tRNA[Ser]Sec, whereas seryl-tRNASer and tRNASer do not bind at all | Mus musculus | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
additional information | SecS occurs in patients with autoimmune chronic hepatitis as an autoimmune factor that co-precipitated tRNA[Ser]Sec in cell extracts of these individuals andis known as the SLA, soluble liver antigen | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 48000, SDS-PAGE | Mus musculus |
? | x * 48000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Sec synthase | - |
Mus musculus |
Sec synthase | - |
Homo sapiens |
SecS | - |
Mus musculus |
SecS | - |
Homo sapiens |
SLA | - |
Mus musculus |
SLA | - |
Homo sapiens |
soluble liver antigen | - |
Mus musculus |
soluble liver antigen | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | SecS is a a PLP-dependent transferase | Mus musculus | |
pyridoxal 5'-phosphate | SecS is a a PLP-dependent transferase | Homo sapiens |