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Literature summary for 2.9.1.1 extracted from

  • Xu, X.M.; Carlson, B.A.; Zhang, Y.; Mix, H.; Kryukov, G.V.; Glass, R.S.; Berry, M.J.; Gladyshev, V.N.; Hatfield, D.L.
    New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea (2007), Biol. Trace Elem. Res., 119, 234-241.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene secS, DNA and amino acid sequence determination and analysis Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Mus musculus
-
-
soluble
-
Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
x * 48000, SDS-PAGE Mus musculus
48000
-
x * 48000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-seryl-tRNASec + selenophosphate Mus musculus sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview L-selenocysteinyl-tRNASec + phosphate
-
?
L-seryl-tRNASec + selenophosphate Homo sapiens sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview L-selenocysteinyl-tRNASec + phosphate
-
?
additional information Homo sapiens SecS occurs in patients with autoimmune chronic hepatitis as an autoimmune factor that co-precipitated tRNA[Ser]Sec in cell extracts of these individuals andis known as the SLA, soluble liver antigen ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-seryl-tRNASec + selenophosphate
-
Homo sapiens L-selenocysteinyl-tRNASec + phosphate
-
?
L-seryl-tRNASec + selenophosphate sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview Mus musculus L-selenocysteinyl-tRNASec + phosphate
-
?
L-seryl-tRNASec + selenophosphate sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview Homo sapiens L-selenocysteinyl-tRNASec + phosphate
-
?
L-seryl-tRNASec + selenophosphate the efficiency of tRNA binding in descending order is O-phosphoseryl-tRNA[Ser]Sec, tRNA[Ser]Sec, and seryl-tRNA[Ser]Sec, whereas seryl-tRNASer and tRNASer do not bind at all Mus musculus L-selenocysteinyl-tRNASec + phosphate
-
?
additional information SecS occurs in patients with autoimmune chronic hepatitis as an autoimmune factor that co-precipitated tRNA[Ser]Sec in cell extracts of these individuals andis known as the SLA, soluble liver antigen Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 48000, SDS-PAGE Mus musculus
? x * 48000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Sec synthase
-
Mus musculus
Sec synthase
-
Homo sapiens
SecS
-
Mus musculus
SecS
-
Homo sapiens
SLA
-
Mus musculus
SLA
-
Homo sapiens
soluble liver antigen
-
Mus musculus
soluble liver antigen
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate SecS is a a PLP-dependent transferase Mus musculus
pyridoxal 5'-phosphate SecS is a a PLP-dependent transferase Homo sapiens