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17beta-estradiol + 3'-phosphoadenylyl sulfate
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phopshoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + resveratrol 3-O-sulfate + resveratrol 4'-O-sulfate + resveratrol 3,4'-O-disulfate
-
i.e. 3,5,4'-trihydroxystilbene, a phytoestrogen with mixed estrogen agonist/antagonist properties developed as a chemopreventive agent, interaction of resveratrol with 17beta-estradiol, overview
three different sulfate products, product identification by NMR, overview
-
?
3'-phosphoadenylyl sulfate + 1,3-benzothiazol-6-ol
adenosine-3',5'-bisphosphate + 1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1,3-benzoxazol-6-ol
adenosine 3',5'-bisphosphate + 1,3-benzoxazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzofuran-5-ol
adenosine 3',5'-bisphosphate + 1-benzofuran-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzofuran-6-ol
adenosine 3',5'-bisphosphate + 1-benzofuran-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzothiophene-5-ol
adenosine 3',5'-bisphosphate + 1-benzothiophene-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzothiophene-6-ol
adenosine 3',5'-bisphosphate + 1-benzothiophene-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl sulfate + 1H-indol-6-ol
adenosine 3',5'-bisphosphate + 1H-indol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-aminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-aminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-iodophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-iodophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-yl suflate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
3'-phosphoadenylyl sulfate + 2-phenyl-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-phenyl-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 3-cyano-7-hydroxycoumarin
adenosine 3',5'-bisphosphate + 3-cyano-7-hydroxycoumaryl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
3'-phosphoadenylyl sulfate + 6-hydroxy-4-methylbenzo[d]thiazole-2-carbonitrile
adenosine 3',5'-bisphosphate + ?
i.e. proluciferin substrate UGT-Glo substrate A, GSA
-
-
?
3'-phosphoadenylyl sulfate + apigenin
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
3'-phosphoadenylyl sulfate + chrysin
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + epicatechin
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
3'-phosphoadenylyl sulfate + ethinyl estradiol
adenosine 3',5'-bisphosphate + ethinyl estradiol 3-sulfate
-
a synthetic oral contraceptive, low activity
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + quercetin
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + tamoxifen
adenosine 3',5'-bisphosphate + tamoxifen sulfate
3'-phosphoadenylyl sulfate + testosterone
adenosine 3',5'-bisphosphate + testosterone sulfate
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,16alpha,17beta-triol
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien-16alpha,17beta-diol 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17alpha-diol
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien 17alpha-ol-3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monoacetate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monoglucosiduronate
adenosine 3',5'-bisphosphate + ?
-
very low sulfation rate
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3,17beta-diol-17-monovalerinate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 1,3,5(10)-estratrien-3-ol
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratrien 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 11-hydroxy-1,3,5(10)-estratrien-17-one
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 16-epiestriol
adenosine 3',5'-bisphosphate + 16-epiestriol 3-sulfate
3'-phosphoadenylylsulfate + 17-deoxyestrone
adenosine 3',5'-bisphosphate + 17-deoxyestrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17-epiestriol
adenosine 3',5'-bisphosphate + 17-epiestriol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate
3'-phosphoadenylylsulfate + 17alpha-ethinylestradiol
adenosine 3',5'-bisphosphate + ?
-
isoform SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 17alpha-ethynyl-1,3,5(10)-estratrien-3,17beta-diol
adenosine 3',5'-bisphosphate + 17alpha-ethynyl-1,3,5(10)-estratrien-17beta-ol 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-4,2',4'-trichlorodiphenyl ether
adenosine 3',5'-bisphosphate + 2-OH-4,2',4'-trichlorodiphenyl ethyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-4,5,3',2',3',4'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 2-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-6,7,8-trichlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-6,7,8-trichlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine
adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,16alpha-dihydroxy-1,3,5(10)-estratrien-17-one
adenosine 3',5'-bisphosphate + 16-alpha-hydroxy-1,3,5(10)-estratrien-17-one 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,17beta-dihydroxy-1,3,5(10),9-estratetraen-12-one
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,17beta-dihydroxy-1,3,5(10)-estratrien-6-one
adenosine 3',5'-bisphosphate + ?
-
high sulfation rate
-
-
r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrabromo-4,4'-isopropylidendiphenol
adenosine 3',5'-bisphosphate + 3,5,3',5'-tetrabromo-4,4'-isopropylidendiphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrachloro-4,4'-isopropylidendiphenol
adenosine 3',5'-bisphosphate + 3,5,3',5'- tetrachloro-4,4'-isopropylidendiphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),6,8-estrapentaen-17-one
adenosine 3',5'-bisphosphate + 1,3,5(10),6,8-estrapentaen-17-one 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),6-estratetraen-17-one
adenosine 3',5'-bisphosphate + 1,3,5(10),6-estratetraen-17-one 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),7-estratetraen-17-one
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10),9-estratetraen-12,17-dione
adenosine 3',5'-bisphosphate + 1,3,5(10),9-estratetraen-12,17-dione 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-hydroxy-1,3,5(10)-estratrien-16-one
adenosine 3',5'-bisphosphate + 1,3,5(10)-estratriene-16-one 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8-tetrachlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 3-OH-4,5,3',4'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 3-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl
adenosine 3',5'-bisphosphate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-nitro-1,3,5(10)estratrien-3,17beta-diol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuran
adenosine 3',5'-bisphosphate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuranyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-2',4',6'-tribromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-2',4',6'-tribromodiphenyl ethyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3',2',4',6'-tetrabromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-3',2',4',6'-tetrabromodiphenyl ethyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3',5,2',4',6'-pentabromodiphenyl ether
adenosine 3',5'-bisphosphate + 4-OH-3',5,2',4',6'- pentabromodiphenyl ethyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 4-OH-3,3',4'-trichlorated biphenyl
adenosine 3',5'-bisphosphate + 4-OH-3,3',4'-trichlorated biphenyl sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 7alpha-methyl-1,3,5(10)-estratrien-3,17beta-diol
adenosine 3',5'-bisphosphate + 7alpha-methyl-1,3,5(10)-estratrien 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 7alpha-methyl-3-hydroxy-1,3,5(10)-estratrien-17-one
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylylsulfate + androstenediol
adenosine 3',5'-bisphosphate + androstenediol sulfate
-
wild-type EST exhibits little ability to sulfate AD
-
r
3'-phosphoadenylylsulfate + butylated hydroxyanisole
adenosine 3',5'-bisphosphate + butylated hydroxyanisole sulfate
-
-
r
3'-phosphoadenylylsulfate + catechin hydrate
adenosine 3',5'-bisphosphate + catechin hydrate sulfate
-
-
r
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + daidzein sulfate
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
3'-phosphoadenylylsulfate + epicatechin
adenosine 3',5'-bisphosphate + epicatechin sulfate
-
-
r
3'-phosphoadenylylsulfate + epigallocatechin gallate
adenosine 3',5'-bisphosphate + epigallocatechin gallate sulfate
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
-
-
r
3'-phosphoadenylylsulfate + hexestrol
adenosine 3',5'-bisphosphate + hexestrol 4-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + kaempferol
adenosine 3',5'-bisphosphate + kaempferol sulfate
-
-
r
3'-phosphoadenylylsulfate + myricetin
adenosine 3',5'-bisphosphate + myricetin sulfate
-
-
r
3'-phosphoadenylylsulfate + n-propyl gallate
adenosine 3',5'-bisphosphate + n-propyl gallate sulfate
-
-
r
3'-phosphoadenylylsulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
3'-phosphoadenylylsulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
3'-phosphoadenylylsulfate + quercetin
adenosine 3',5'-bisphosphate + quercetin sulfate
3'-phosphoadenylylsulfate + resveratrol
adenosine 3',5'-bisphosphate + resveratrol sulfate
-
-
-
r
3'-phosphoadenylylsulfate + stilbestrol
adenosine 3',5'-bisphosphate + stilbestrol 4-sulfate
-
-
-
r
8-bromoadenosine 3'-phosphate 5'-phosphosulfate + estrone
8-bromoadenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
-
r
adenosine 3'-phosphate 5'-phosphosulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
-
r
formycin 3'-phosphate 5'-phosphosulfate + estrone
formycin 3',5'-bisphosphate + estrone sulfate
-
-
-
-
r
tubercidin 3'-phosphate 5'-phosphosulfate + estrone
tubercidin 3',5'-bisphosphate + estrone sulfate
-
-
-
-
r
additional information
?
-
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
best substrate
-
-
?
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
17beta-estradiol regulates growth and differentiation in normal and malignant bone, it is inactivated to 17beta-estradiol-sulfate through SULT1E1
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
SULT1E1 has a high affinity and catalytic efficiency for estradiol as substrate
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
inactivation
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
inactivation, increased 17beta-estradiol sulfation affects the GH signaling pathway and E2-regulated gene expression, enhanced SULT1E1 activity plays a role in inhibiting GH-stimulated STAT5b phosphorylation and IGF-1 synthesis via the sulfation and inactivation of 17beta-estradiol, regulation, overview
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
reaction of phenol sulfonyltransferase, EC 2.8.2.1, determination of reaction equilibrium in the forward direction at 70% of conversion of 4-nitrophenol
-
-
r
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
best substrate
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
SULT1E1 is involved in estrogen inactivation
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
high activity by SULT1E1, low activity by SULT1A1, EC 2.8.2.1
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
isozyme SULT1E1 is specific for estradiol sulfonation, interaction of resveratrol with 17beta-estradiol, overview
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
EST expression and regulation in invasive breast cancer and ductal carcinoma in situ, overview
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
estradiol sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
SULT1E1 acts at nanomolar concentration of estradiol. SULT1A1 is active at micromolar concentration of estradiol and has an affinity 300fold lower than SULT1E1
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
r
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
SULT1E1 is involved in estrogen inactivation
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
high activity by SULT1E1, low activity by phenol sulfotransferase SULT1A1, EC 2.8.2.1
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
estrone sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + tamoxifen
adenosine 3',5'-bisphosphate + tamoxifen sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + tamoxifen
adenosine 3',5'-bisphosphate + tamoxifen sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + tamoxifen
adenosine 3',5'-bisphosphate + tamoxifen sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + testosterone
adenosine 3',5'-bisphosphate + testosterone sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + testosterone
adenosine 3',5'-bisphosphate + testosterone sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 16-epiestriol
adenosine 3',5'-bisphosphate + 16-epiestriol 3-sulfate
-
1,3,5(10)estratiene-3,16beta,17beta-triol
-
r
3'-phosphoadenylylsulfate + 16-epiestriol
adenosine 3',5'-bisphosphate + 16-epiestriol 3-sulfate
-
1,3,5(10)estratiene-3,16beta,17beta-triol
-
-
r
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
r
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
isoform rEST-6
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
best substrate
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
enzyme does not distinguish between estradiol and estrone, both appear to be natural substrates
-
-
r
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estriol
adenosine 3',5'-bisphosphate + estriol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
-
-
-
?
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
steroid metabolism
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
also involved in the regulation of 17beta-estradiol levels in target tissue cells
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
isoform rEST-6
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
?
3'-phosphoadenylylsulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
-
-
-
r
3'-phosphoadenylylsulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
-
-
-
r
3'-phosphoadenylylsulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
-
model substrate, sulfonated by SULT1E1
-
r
3'-phosphoadenylylsulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + quercetin
adenosine 3',5'-bisphosphate + quercetin sulfate
-
-
-
r
3'-phosphoadenylylsulfate + quercetin
adenosine 3',5'-bisphosphate + quercetin sulfate
-
-
r
additional information
?
-
-
-
-
-
?
additional information
?
-
-
dehydroepiandrosterone, etiocholanolone, 11-deoxycorticosterone, 17beta-oestradiol-3-methyl ether, testosterone, pregnenolone, beta-naphthylamine and p-nitrophenol are no substrates
-
-
?
additional information
?
-
-
enzyme does not sulfate an OH in position 2 or 4 of estrogens but sulfates, with decreased efficiency, the phenolic-OH on 6-benzoyl-naphthol, anthraquinone, fluorenes, diphenyl and tetraline, almost no sulfation of 4-hydroxybenzoic acid esters
-
-
?
additional information
?
-
-
simple phenols or steroid alcohols are no substrates
-
-
?
additional information
?
-
-
dehydroepiandrosterone is no substrate
-
-
?
additional information
?
-
-
simple phenols, 2-naphthylamine and 3beta-hydroxysteroids are not sulfated, dienestrol is no substrate, dehydroepiandrosterone, phenol, p-nitrophenol, alpha-naphthol, beta-naphthol, beta-naphthylamine and 17 beta-estradiol-3-methyl ether fail to act as substrates
-
-
?
additional information
?
-
excess SULT1E1 is the reason for perturbed low ratio of active to inactive estrogens and the resulting hormonal imbalance contributing to the lack of overt signs of readiness for partirition in cows pregnant with clones
-
-
?
additional information
?
-
-
estrogen levels in healthy canine mammary gland and in canine inflammatory mammary carcinoma in relation to expression levels of enzymes involved in the estrogen metabolism, overview
-
-
?
additional information
?
-
-
p-nitrophenol and several neutral steroids are no substrates
-
-
?
additional information
?
-
-
activity toward dehydroepiandrosterone and testosterone is minimal or undetectable
-
-
?
additional information
?
-
-
dopamine is no substrate
-
-
?
additional information
?
-
caffeic acid, chlorogenic acid, BHT, and gallic acid are no substrates
-
-
?
additional information
?
-
-
1-hydroxy-2,4,7,8-tetrachlorodibenzofuran is no substrate
-
-
?
additional information
?
-
-
knockout of the cystic fibrosis transmembrane conductance regulator, CFTR, leads to increased SULT1E1 expression, estrogen levels play a role in development of cystic fibrosis
-
-
?
additional information
?
-
-
local production of estrogens in human peripheral tissues and/or breast carcinoma, overview
-
-
?
additional information
?
-
-
local regulation of estradiol and EST in ductal carcinoma, DCIS, correlation between aromatase and EST expression and grade of malignancy in ductal carcinoma, overview
-
-
?
additional information
?
-
-
phytoestrogens can potentially alter the homeostasis of estrogen levels
-
-
?
additional information
?
-
-
progestins, which activate the enzyme decrease cell proliferation of breast cancer cell lines, overview
-
-
?
additional information
?
-
-
SULT1E1 catalyzes the sulfation of endogenous estrogens as well as xenobiotic estrogen-like chemicals. This reaction increases the water solubility of the molecule, which may affect its cellular distribution and biological activity, and alter estrogen signaling to the estrogen receptor in human estrogen receptor-positive cells
-
-
?
additional information
?
-
SULT1E1 catalyzes the sulfation of endogenous estrogens as well as xenobiotic estrogen-like chemicals. This reaction increases the water solubility of the molecule, which may affect its cellular distribution and biological activity, and alter estrogen signaling to the estrogen receptor in human estrogen receptor-positive cells
-
-
?
additional information
?
-
SULTs play a role in the metabolism of regulatory hormones, drugs, and carcinogens, they catalyze the sulfonation of simple phenols, estradiol, and thyroid hormones, as well as environmental xenobiotics and drugs, overview
-
-
?
additional information
?
-
role for 3'-phosphoadenylyl sulfate in priming the conformation of substrate binding loops, overview, substrate specificity and binding structure of SULT1E1, overview
-
-
?
additional information
?
-
-
the reaction is also performed by the phenol sulfotranferase, EC 2.8.2.1, but with lower activity
-
-
?
additional information
?
-
-
chronic topical application of parabens may lead to prolonged estrogenic effects in skin as a result of inhibition of estrogen sulfotransferase activity, overview. The skin anti-aging benefits of many topical cosmetics and pharmaceuticals could be derived, in part, from the estrogenicity of parabens
-
-
?
additional information
?
-
-
concerted action of catechol-O-methyltransferase and the cytosolic sulfotransferase, SULT, enzyme(s) in the metabolism of catecholestrogens with production of sulfated 2-methoxy-estrone or sulfated 2- or 4-methoxy-estradiol, overview
-
-
?
additional information
?
-
-
cytosolic sulfotransferase SULT1E1 catalyzes the sulfation of endogenous estrogens as well as xenobiotic estrogen-like chemicals
-
-
?
additional information
?
-
cytosolic sulfotransferase SULT1E1 catalyzes the sulfation of endogenous estrogens as well as xenobiotic estrogen-like chemicals
-
-
?
additional information
?
-
-
EST catalyzes the transfer of a sulfuryl group to estrogens and might be involved in endometriosis, an estrogen-dependent gynecological disease, characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity, causing pelvic pain and infertility. Impaired estrogen metabolism plays a pivotal role in the pathogenesis of the disease, overview
-
-
?
additional information
?
-
-
estrogen exposure is a risk factor for gallstone disease, cholelithiasis, which often leads to chronic inflammation, cholecystitis. SULT1E1 is a key enzymes involved in the inactivation of estrogens. Estrogen concentrations in human gallbladder are regulated by a network of activating STS and inactivating SULT1E1, and estrogen receptors alpha and beta, localization in tissue, overview
-
-
?
additional information
?
-
-
SULT1E1 and ID2 genes are candidates for inherited predisposition to breast and ovarian cancer in Jewish women
-
-
?
additional information
?
-
-
SULT1E1 catalyzes the sulfate conjugation of estrone, estradiol, catecholestrogens, and 2-methyl-estradiol. SULT1E1 polymorphisms, together with other SULT enzyme polymorphisms, are risk factors for endometrial cancer susceptibility
-
-
?
additional information
?
-
-
SULT1E1 has a major role in estrogen conjugation. Important role for SULT isozymes and their pharmacogenetics in polyphenol disposition
-
-
?
additional information
?
-
SULT1E1 has a major role in estrogen conjugation. Important role for SULT isozymes and their pharmacogenetics in polyphenol disposition
-
-
?
additional information
?
-
-
SULT1E1 is involved in breast cancer cell proloferation, overview
-
-
?
additional information
?
-
-
SULT1E1 or EST is an enzyme important for the metabolic deactivation of estrogens, because sulfonated estrogens fail to activate the estrogen receptor. ectopic expression of SULT1E1 in MCF-7 cells suppresses the estrogen response. SULT1E1 is a transcriptional target of the glucocorticoid receptor, molecular mechanism, overview
-
-
?
additional information
?
-
-
SULT1E1 plays a regulatory role in estrogen signaling activities in human reproductive cells, including the prostate cells. SULT1E1 may function as a transcriptional mediator in transfected human prostate cancer CA-HPV-10 cells, molecular mechanism, overview
-
-
?
additional information
?
-
-
the endocrinological status of women bearing polycystic ovarian syndrome, PCOS, affects the endometrial in situ steroid metabolism, which involves EST, overview
-
-
?
additional information
?
-
-
the enzyme responsible for the formation of the biologically inactive estrogen sulfates
-
-
?
additional information
?
-
-
the redox regulation of hSULT1E1 may interrupt the regulation and function of estrogens under various physiological and pathological conditions
-
-
?
additional information
?
-
-
differential sulfating activities of the human SULTs toward catecholestrogens and nethoxyestrogens, overview
-
-
?
additional information
?
-
SULT1E1 catalyzes the sulfation of estradiol and other phenolic steroids
-
-
-
additional information
?
-
EST has a particularly high affinity for estrogens as substrates including estradiol (17beta-estradiol), estrone, and a variety of synthetic estrogens, like diethylstilbestrol and tamoxifen. EST also exhibits a low affinity for thyroid hormones, testosterones, or glucocorticoids
-
-
-
additional information
?
-
human estrogen sulfotransferase and its related fluorescently labeled decapeptides with a YKDG sequence specifically interact with oxidized low-density lipoprotein. Interaction between human SULT1E1 (hSULT1E1), which has a YKEG sequence (residues 61-64) unlike other human SULTs, and Ox-LDL. hSULT1E1 specifically binds to Ox-LDL and its major lipid component (lysophosphatidylcholine, LPC), and platelet-activating factor (PAF), which bear a marked resemblance to LPC in terms of structure and activity. An N-terminally fluorescein isothiocyanate (FITC)-labeled decapeptide (MIYKEGDVEK, FITC-hSULT1E1-P10) corresponding to residues 59-68 of hSULT1E1 also specifically binds to Ox-LDL, LPC, and PAF
-
-
-
additional information
?
-
-
human estrogen sulfotransferase and its related fluorescently labeled decapeptides with a YKDG sequence specifically interact with oxidized low-density lipoprotein. Interaction between human SULT1E1 (hSULT1E1), which has a YKEG sequence (residues 61-64) unlike other human SULTs, and Ox-LDL. hSULT1E1 specifically binds to Ox-LDL and its major lipid component (lysophosphatidylcholine, LPC), and platelet-activating factor (PAF), which bear a marked resemblance to LPC in terms of structure and activity. An N-terminally fluorescein isothiocyanate (FITC)-labeled decapeptide (MIYKEGDVEK, FITC-hSULT1E1-P10) corresponding to residues 59-68 of hSULT1E1 also specifically binds to Ox-LDL, LPC, and PAF
-
-
-
additional information
?
-
-
dehydroepiandrosterone and pregnenolone are no substrates
-
-
?
additional information
?
-
-
very little reactivity toward hydroxysteroids such as dehydroepiandrosterone
-
-
?
additional information
?
-
-
the role of the enzyme is most probably to protect male tissues against estronic action
-
-
?
additional information
?
-
-
knockout of the cystic fibrosis transmembrane conductance regulator, CFTR, leads to increased SULT1E1 expression, estrogen levels play a role in development of cystic fibrosis
-
-
?
additional information
?
-
-
SULT1E1 or EST is an enzyme important for the metabolic deactivation of estrogens, because sulfonated estrogens fail to activate the estrogen receptor. Ectopic expression of SULT1E1 in MCF-7 cells suppresses the estrogen response. Dexamethasone inhibits mouse uterine estrogen responses in a Sult1E1/EST-dependent manner. SULT1E1 is a transcriptional target of the glucocorticoid receptor, molecular mechanism, overview
-
-
?
additional information
?
-
-
the enzyme inactivates estrogen through sulfoconjugation
-
-
?
additional information
?
-
EST has a particularly high affinity for estrogens as substrates including estradiol (17beta-estradiol), estrone, and a variety of synthetic estrogens, like diethylstilbestrol and tamoxifen. EST also exhibits a low affinity for thyroid hormones, testosterones, or glucocorticoids
-
-
-
additional information
?
-
EST has a particularly high affinity for estrogens as substrates including estradiol (17beta-estradiol), estrone, and a variety of synthetic estrogens, like diethylstilbestrol and tamoxifen. EST also exhibits a low affinity for thyroid hormones, testosterones, or glucocorticoids
-
-
-
additional information
?
-
-
isoform rEST-6 selectively expressed in male rats sulfates estrogens, but dehydroepiandrosterone, pregnenolone, cortisol or testosterone are no substrates
-
-
?
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3'-phosphoadenylyl sulfate + 1,3-benzothiazol-6-ol
adenosine-3',5'-bisphosphate + 1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1,3-benzoxazol-6-ol
adenosine 3',5'-bisphosphate + 1,3-benzoxazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzofuran-5-ol
adenosine 3',5'-bisphosphate + 1-benzofuran-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzofuran-6-ol
adenosine 3',5'-bisphosphate + 1-benzofuran-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzothiophene-5-ol
adenosine 3',5'-bisphosphate + 1-benzothiophene-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-benzothiophene-6-ol
adenosine 3',5'-bisphosphate + 1-benzothiophene-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl sulfate + 1H-indol-6-ol
adenosine 3',5'-bisphosphate + 1H-indol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-aminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-aminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-iodophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-iodophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-yl suflate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-phenyl-1,3-benzothiazol-6-ol
adenosine 3',5'-bisphosphate + 2-phenyl-1,3-benzothiazol-6-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol
adenosine 3',5'-bisphosphate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-yl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + ?
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + tamoxifen
adenosine 3',5'-bisphosphate + tamoxifen sulfate
3'-phosphoadenylyl sulfate + testosterone
adenosine 3',5'-bisphosphate + testosterone sulfate
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
?
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
additional information
?
-
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
best substrate
-
-
?
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
17beta-estradiol regulates growth and differentiation in normal and malignant bone, it is inactivated to 17beta-estradiol-sulfate through SULT1E1
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
inactivation, increased 17beta-estradiol sulfation affects the GH signaling pathway and E2-regulated gene expression, enhanced SULT1E1 activity plays a role in inhibiting GH-stimulated STAT5b phosphorylation and IGF-1 synthesis via the sulfation and inactivation of 17beta-estradiol, regulation, overview
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
r
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + diethylstilbestrol
adenosine 3',5'-bisphosphate + diethylstilbestrol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
SULT1E1 is involved in estrogen inactivation
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
EST expression and regulation in invasive breast cancer and ductal carcinoma in situ, overview
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
estradiol sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
SULT1E1 is involved in estrogen inactivation
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
estrone sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + tamoxifen
adenosine 3',5'-bisphosphate + tamoxifen sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + tamoxifen
adenosine 3',5'-bisphosphate + tamoxifen sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + tamoxifen
adenosine 3',5'-bisphosphate + tamoxifen sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + testosterone
adenosine 3',5'-bisphosphate + testosterone sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + testosterone
adenosine 3',5'-bisphosphate + testosterone sulfate
-
-
-
?
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
best substrate
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
enzyme does not distinguish between estradiol and estrone, both appear to be natural substrates
-
-
r
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
-
-
-
?
3'-phosphoadenylylsulfate + estrogen
adenosine 3',5'-bisphosphate + estrogen sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
steroid metabolism
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
also involved in the regulation of 17beta-estradiol levels in target tissue cells
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
-
r
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
?
additional information
?
-
excess SULT1E1 is the reason for perturbed low ratio of active to inactive estrogens and the resulting hormonal imbalance contributing to the lack of overt signs of readiness for partirition in cows pregnant with clones
-
-
?
additional information
?
-
-
estrogen levels in healthy canine mammary gland and in canine inflammatory mammary carcinoma in relation to expression levels of enzymes involved in the estrogen metabolism, overview
-
-
?
additional information
?
-
-
knockout of the cystic fibrosis transmembrane conductance regulator, CFTR, leads to increased SULT1E1 expression, estrogen levels play a role in development of cystic fibrosis
-
-
?
additional information
?
-
-
local production of estrogens in human peripheral tissues and/or breast carcinoma, overview
-
-
?
additional information
?
-
-
local regulation of estradiol and EST in ductal carcinoma, DCIS, correlation between aromatase and EST expression and grade of malignancy in ductal carcinoma, overview
-
-
?
additional information
?
-
-
phytoestrogens can potentially alter the homeostasis of estrogen levels
-
-
?
additional information
?
-
-
progestins, which activate the enzyme decrease cell proliferation of breast cancer cell lines, overview
-
-
?
additional information
?
-
-
SULT1E1 catalyzes the sulfation of endogenous estrogens as well as xenobiotic estrogen-like chemicals. This reaction increases the water solubility of the molecule, which may affect its cellular distribution and biological activity, and alter estrogen signaling to the estrogen receptor in human estrogen receptor-positive cells
-
-
?
additional information
?
-
SULT1E1 catalyzes the sulfation of endogenous estrogens as well as xenobiotic estrogen-like chemicals. This reaction increases the water solubility of the molecule, which may affect its cellular distribution and biological activity, and alter estrogen signaling to the estrogen receptor in human estrogen receptor-positive cells
-
-
?
additional information
?
-
SULTs play a role in the metabolism of regulatory hormones, drugs, and carcinogens, they catalyze the sulfonation of simple phenols, estradiol, and thyroid hormones, as well as environmental xenobiotics and drugs, overview
-
-
?
additional information
?
-
-
chronic topical application of parabens may lead to prolonged estrogenic effects in skin as a result of inhibition of estrogen sulfotransferase activity, overview. The skin anti-aging benefits of many topical cosmetics and pharmaceuticals could be derived, in part, from the estrogenicity of parabens
-
-
?
additional information
?
-
-
concerted action of catechol-O-methyltransferase and the cytosolic sulfotransferase, SULT, enzyme(s) in the metabolism of catecholestrogens with production of sulfated 2-methoxy-estrone or sulfated 2- or 4-methoxy-estradiol, overview
-
-
?
additional information
?
-
-
cytosolic sulfotransferase SULT1E1 catalyzes the sulfation of endogenous estrogens as well as xenobiotic estrogen-like chemicals
-
-
?
additional information
?
-
cytosolic sulfotransferase SULT1E1 catalyzes the sulfation of endogenous estrogens as well as xenobiotic estrogen-like chemicals
-
-
?
additional information
?
-
-
EST catalyzes the transfer of a sulfuryl group to estrogens and might be involved in endometriosis, an estrogen-dependent gynecological disease, characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity, causing pelvic pain and infertility. Impaired estrogen metabolism plays a pivotal role in the pathogenesis of the disease, overview
-
-
?
additional information
?
-
-
estrogen exposure is a risk factor for gallstone disease, cholelithiasis, which often leads to chronic inflammation, cholecystitis. SULT1E1 is a key enzymes involved in the inactivation of estrogens. Estrogen concentrations in human gallbladder are regulated by a network of activating STS and inactivating SULT1E1, and estrogen receptors alpha and beta, localization in tissue, overview
-
-
?
additional information
?
-
-
SULT1E1 and ID2 genes are candidates for inherited predisposition to breast and ovarian cancer in Jewish women
-
-
?
additional information
?
-
-
SULT1E1 catalyzes the sulfate conjugation of estrone, estradiol, catecholestrogens, and 2-methyl-estradiol. SULT1E1 polymorphisms, together with other SULT enzyme polymorphisms, are risk factors for endometrial cancer susceptibility
-
-
?
additional information
?
-
-
SULT1E1 has a major role in estrogen conjugation. Important role for SULT isozymes and their pharmacogenetics in polyphenol disposition
-
-
?
additional information
?
-
SULT1E1 has a major role in estrogen conjugation. Important role for SULT isozymes and their pharmacogenetics in polyphenol disposition
-
-
?
additional information
?
-
-
SULT1E1 is involved in breast cancer cell proloferation, overview
-
-
?
additional information
?
-
-
SULT1E1 or EST is an enzyme important for the metabolic deactivation of estrogens, because sulfonated estrogens fail to activate the estrogen receptor. ectopic expression of SULT1E1 in MCF-7 cells suppresses the estrogen response. SULT1E1 is a transcriptional target of the glucocorticoid receptor, molecular mechanism, overview
-
-
?
additional information
?
-
-
SULT1E1 plays a regulatory role in estrogen signaling activities in human reproductive cells, including the prostate cells. SULT1E1 may function as a transcriptional mediator in transfected human prostate cancer CA-HPV-10 cells, molecular mechanism, overview
-
-
?
additional information
?
-
-
the endocrinological status of women bearing polycystic ovarian syndrome, PCOS, affects the endometrial in situ steroid metabolism, which involves EST, overview
-
-
?
additional information
?
-
-
the enzyme responsible for the formation of the biologically inactive estrogen sulfates
-
-
?
additional information
?
-
-
the redox regulation of hSULT1E1 may interrupt the regulation and function of estrogens under various physiological and pathological conditions
-
-
?
additional information
?
-
SULT1E1 catalyzes the sulfation of estradiol and other phenolic steroids
-
-
-
additional information
?
-
-
the role of the enzyme is most probably to protect male tissues against estronic action
-
-
?
additional information
?
-
-
knockout of the cystic fibrosis transmembrane conductance regulator, CFTR, leads to increased SULT1E1 expression, estrogen levels play a role in development of cystic fibrosis
-
-
?
additional information
?
-
-
SULT1E1 or EST is an enzyme important for the metabolic deactivation of estrogens, because sulfonated estrogens fail to activate the estrogen receptor. Ectopic expression of SULT1E1 in MCF-7 cells suppresses the estrogen response. Dexamethasone inhibits mouse uterine estrogen responses in a Sult1E1/EST-dependent manner. SULT1E1 is a transcriptional target of the glucocorticoid receptor, molecular mechanism, overview
-
-
?
additional information
?
-
-
the enzyme inactivates estrogen through sulfoconjugation
-
-
?
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(+)-6beta-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one
-
(-)-6,9:15,16-diepoxy-9alpha-hydroxy-8,9-seco-13(16),14-labdadiene-7-one
-
(17beta)-3,17-dihydroxy-1,3,5(10)estatriene-6-one
-
-
(17beta)-3-methoxyestra-1(10),2,4-trien-17-ol
-
-
(7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3',5'-diphosphate
-
-
1,3,5(10)estatriene-17beta-ol
-
-
1,3,5(10)estatriene-3,16alpha,17beta-triol
-
-
1,3,5(10)estatriene-3,16alpha-diol
-
-
1,3,5(10)estatriene-3,16beta,17beta-triol
-
-
1,3,5(10)estatriene-3,17beta-diol
-
-
1,3,5(10)estatriene-3,17beta-diol 17beta-phosphate
-
-
1,3,5(10)estatriene-3,17beta-diol 17beta-sulfate
-
-
1,3,5(10)estatriene-3,17beta-diol 3,17beta-diphosphate
-
-
1,3,5(10)estatriene-3,17beta-diol 3-phosphate
-
-
1,3,5(10)estatriene-3,17beta-diol-3-acetate
-
-
1,3,5(10)estatriene-3,17beta-diol-3-benzoate
-
-
1,3,5(10)estatriene-3-ol
-
-
1,3,5(10)estatriene-3-ol 17-one 3-sulfate
-
-
1-[2-(p-[3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl]phenoxy)ethyl]-pyrrolidine hydrochloride
-
-
16alpha-hydroxyestrone
-
maximum inhibition at 100 nM
17beta-hydroxy-5alpha-androstane-3-one
-
-
17beta-hydroxy-5beta-androstane-3-one
-
-
2,2',3',4,4',5,5'-heptachloro[1,1'-biphenyl]-3-ol
-
-
2,2',5,5'-tetrachloro-4-hydroxybiphenyl
-
-
2,3',4-trichloro-4'-hydroxybiphenyl
the inhibitor has been identified as a metabolite in human plasma with an estimated half-life of 6.5 years
-
2,4'-dichloro-4-hydroxybiphenyl
-
-
2,4,6-Trichlorophenol
-
-
2,4-dibromo-1,3,5(10)estatriene-3,17beta-diol
-
-
2,4-dinitro-1,3,5(10)estatriene-3,17beta-diol
-
-
2,6-Dichloro-4-nitrophenol
2-amino-1,3,5(10)estatriene-3,17beta-diol
-
-
2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin
-
-
2-hydroxy-3,4,2',3',4'-pentachlorobiphenyl
-
-
2-hydroxy-3,4,3',4'-tetrachlorobiphenyl
-
-
2-hydroxy-4,5,3',4'-tetrachlorobiphenyl
-
-
2-hydroxy-7,8-dichlorodibenzo-p-dioxin
-
-
2-hydroxy-7,8-dichlorodibenzofuran
-
-
2-nitro-1,3,5(10)estatriene-3,17beta-diol
-
-
2-OH-3,2'-dibromobiphenyl
-
-
3',4',7-trihydroxyisoflavone
-
-
3'-phosphoadenylylsulfate
3,3',5,5'-tetrachlorobisphenol A
-
-
3,3'-(hydroxy)2-4,4'-dichlorobiphenyl
-
-
3,3'-dichloro-4-hydroxybiphenyl
-
-
3,5-dibromo-4-hydroxy-benzoic acid (6-chloro-4-oxo-4H-chromen-3-ylmethylene)-hydrazide
DBHM
3,5-dibromo-4-hydroxybenzoic acid (6,8-dichloro-4-oxo-4H-chromen-3-ylmethylene) hydrazide
DBHD
3-hydroxy-2,4,5,3',4'-pentachlorobiphenyl
-
-
3-hydroxy-2,4,7,8,9-pentachlorodibenzofuran
-
-
3-hydroxy-2,4,7,8-tetrachlorodibenzofuran
-
-
3-hydroxy-4,5,2',3',4'-pentachlorobiphenyl
-
-
3-hydroxy-4,5,3',4',5'-pentachlorobiphenyl
-
-
3-hydroxy-4,5,3',4'-tetrachlorobiphenyl
-
-
3-hydroxyestra-1(10),2,4-trien-17-one
-
-
3-methoxy-4-nitroestra-1(10),2,4-trien-17-one
-
-
3-OH-2,2'-dibromobiphenyl
-
-
3-OH-4,4'-dibromobiphenyl
-
-
3alpha-tibolone
-
activates SULT1E1 in MCF-7 cells by 50% and 37% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 63%
3beta-hydroxy-5beta-androstane-17-one
-
-
3beta-hydroxy-androst-5-ene-17-one
-
-
3beta-tibolone
-
activates SULT1E1 in MCF-7 cells by 101% and 74% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 54%
4,4'-(hydroxy)2-3,5,'3',5'-tetrachlorobiphenyl
-
-
4,4'-isopropyl idenediphenol-3,3',5,5'-tetrachlorobisphenol
-
-
4,4'-isopropylidenediphenol
-
-
4-amino-1,3,5(10)estatriene-3,17beta-diol
-
-
4-chloro-4'-hydroxybiphenyl
-
-
4-ene tibolone
-
inhibits at high concentrations of 0.05 mM by 59%
4-hydroxy-2',3',4',5'-tetrachlorobiphenyl
-
-
4-hydroxy-2',4',6'-trichlorobiphenyl
-
-
4-hydroxy-2,2',3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',3',5',6'-pentachlorobiphenyl
-
-
4-hydroxy-2,2',4',6'-tetrachlorobiphenyl
-
-
4-hydroxy-2,3,4,5,6-pentabromodiphenylether
-
-
4-hydroxy-2,3,5,2',3',4',5'-heptachlorobiphenyl
-
-
4-hydroxy-2,3,5,2',3',4'-hexachlorobiphenyl
-
-
4-hydroxy-2,3,5,2',4',5'-hexachlorobiphenyl
-
-
4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
-
-
4-hydroxy-2,3,5,6,2',4',5'-heptachlorobiphenyl
-
-
4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',3',4',6'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',3',5',6'-pentachlorobiphenyl
-
-
4-hydroxy-3,2',4',6'-tetrachlorobiphenyl
-
-
4-hydroxy-3,3',4'-trichlorobiphenyl
-
-
4-hydroxy-3,5,2',3',4',5'-hexachlorobiphenyl
-
-
4-hydroxy-3,5,2',3',4'-pentachlorobiphenyl
-
-
4-hydroxy-3,5,3',4',5'-pentachlorobiphenyl
-
-
4-hydroxy-3,5,3',4'-tetrachlorobiphenyl
-
-
4-hydroxy-3,5,3',5'-tetrachlorobiphenyl
-
-
4-hydroxybenzoate esters
-
i.e.parabens, structure-activity relationship, overview
4-hydroxybenzoic acid
-
-
4-nitro-1,3,5(10)estatriene-3,17beta-diol
-
-
4-OH-2,2'-dibromobiphenyl
-
-
4-OH-3,4'-dibromobiphenyl
-
-
4-OH-4'-monobromobiphenyl
-
-
5,7-dichlorokynurenic acid
-
5-androstene-3beta,17beta-diol
-
-
5alpha-Androstane-3beta,17beta-diol
-
-
6-OH-2,2'-dibromobiphenyl
-
-
7-deazadenosine
-
tubercidin
8-bromoadenosine 3',5'-diphosphate
-
-
8-bromoadenosine 3'-phosphate 5'-phosphosulfate
-
-
abiraterone
antiandrogen drug, metabolite abiraterone, not the parent drug abiraterone acetate, is responsible for the inhibition
Acetylsalicylate
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
adenosine 2',5'-diphosphate
-
noncompetitive inhibition
adenosine 3',5'-diphosphate
-
-
adenosine 3'-diphosphate 5'-phosphate
-
-
adenosine 3'-phosphate 5'-diphosphate
-
-
adenosine 5'-(beta,gamma-imido) triphosphate
i.e. AMP-PNP, a non-hydrolysable ATP analogue
adenosine 5'-phosphosulfate
-
-
adenosine N1-oxide 3,5'-diphosphate
-
-
androst-5-ene-3beta-ol
-
-
ATP
-
mixed-type inhibition
buthionine sulfoxamine
-
a GSH depletor, decreases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells
butylparaben
-
50% inhibition at 0.021 mM, complete inhibition at 1 mM; strong inhibition, which is threefold higher in vivo than in vitro
cetyltrimethylammonium bromide
-
-
chloroform
-
excess chloroform inactivates
daidzein 4,7-bissulfate
-
IC50: 0.01 mM
dithiothreitol
-
inhibition above 0.005 mM
equol
-
potent mixed type inhibitor
ethylparaben
-
50% inhibition at 0.080 mM
fatty acid
-
unsaturated fatty acid of chain length C11-C14
formycin 3'-phosphate 5'-phosphosulfate
-
-
galeterone
antiandrogen drug
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
genistein
-
potent mixed type inhibitor
GSSG
-
oxidized glutathione, inactivation and kinetics, adenosine 3'-phosphate 5'-phosphosulfate protects
guanosine 2',3'-cyclic phosphate 5'-phosphate
-
-
hydroxylated polychlorated biphenyls
-
-
-
ICI 182,720
-
produces a marked decrease (over 50%) of EST activity with respect to untreated control cell cultures at 24 h
inosine 3',5'-diphosphate
-
-
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
leosibiric acid A
most potent inhibition
meclofenamate
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
medrogestone
-
biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview
methylparaben
-
50% inhibition at 0.330 mM
myristate
-
inhibition is non-competitive with respect to the substrate estrone
N6-dimethylaminoadenosine 3',5'-diphosphate
-
-
nebularine 3',5'-diphosphate
-
-
nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate
-
-
nimesulide
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
o-Iodosobenzoate
-
sensitive above 10 mM
OrgOD14
-
active substance in Livial (r), above 0.05 mM decreases significantly biosynthesis of estrone by 50-60%, no effect in MDA-MB-231 cells
p-chloromercuribenzoate
-
sensitive above 1 mM
p-hydroxymercuribenzoate
-
-
Promegestone
-
activates SULT1E1 by 26% at low concentrations of 500 nM, inhibits at 0.05 mM by 41%, leads to increased and decreased expression levels, respetively; biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview
propylparaben
-
50% inhibition at 0.030 mM
pyridoxal 5'-phosphate
a competitive inhibitor for sulfotransferases
Sodium dodecyl sulfate
-
-
tamoxifen
-
weak inhibition
tibolone
-
activates SULT1E1 in MCF-7 cells by 63% and 44% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 64%
trans-resveratrol
-
0.1 mM resveratrol significantly decreases the SULT1E1-mediated beta-estradiol sulfation
tributyltin
-
a common androgenic marine pollutant
tubercidin 2',5'-diphosphate
tubercidin 3',5'-bisphosphate
-
-
tubercidin 3'-phosphate 5'-phosphosulfate
-
-
ZnCl2
-
inhibition of liver isoenzyme at 15 mM
17beta-estradiol
-
inhibits sulfation of estrone
17beta-estradiol
-
partial substrate inhibitor
17beta-estradiol
-
17beta-estradiol is a partial kcat-inhibitor (saturation with inhibitor decreases kcat about 7fold without altering Km for PAPS)
17beta-estradiol
-
substrate inhibition
2,6-Dichloro-4-nitrophenol
-
-
2,6-Dichloro-4-nitrophenol
DCNP
3'-phosphoadenylylsulfate
-
competitive inhibition
3'-phosphoadenylylsulfate
-
competitive inhibition
3'-phosphoadenylylsulfate
-
-
4-nonyl phenol
-
a common estrogenic marine pollutant
4-nonyl phenol
-
a common estrogenic marine pollutant
ADP
-
non-competitive inhibition
ADP
-
non-competitive inhibitor
estrone
-
inhibits sulfation of estradiol
estrone
-
substrate inhibition
Mefenamic acid
-
-
quercetin
-
competitive inhibition
quercetin
a potent inhibitor of SULT1E1
resveratrol
-
competitive inhibition
resveratrol
-
inhibits estradiol sulfonation, phytoestrogen with mixed estrogen agonist/antagonist properties developed as a chemopreventive agent, interaction of resveratrol with 17beta-estradiol
triclosan
-
triclosan
-
triclosan directly inhibits and indirectly induces certain phase II UDP-glucuronosyltransferase (UGT) and PAPS-sulfotransferase (SULT) enzymes. It is an especially potent competitive inhibitor of ovine placental estrogen sulfotransferase
Triphenyltin
-
a common androgenic marine pollutant
Triphenyltin
-
a common androgenic marine pollutant
tubercidin 2',5'-diphosphate
-
-
tubercidin 2',5'-diphosphate
-
noncompetitive inhibition
additional information
-
only moderately sensitive to SH-blocking agents, no inhibition with EDTA up to 20 mM
-
additional information
-
5alpha-androstanes are weak competitive inhibitors, the product estrone sulfate is not inhibitory, no inhibition with 1,3,5(10)estatriene, 1,3,5,(10)estatriene-3,17beta-diol 3,17beta-disulfate, MER-25, 1-[p-2-diethylaminoethoxyphenyl]-1-phenyl-2-p-methoxyphenyl ethanol and 5-androstene
-
additional information
-
3,4,3',4'-tetrachlorbiphenyl is no inhibitor
-
additional information
-
native liver enzyme is less potently inhibited than recombinant SULT1E1
-
additional information
-
low SULT1E1 and/or high steroid sulfatase expression in breast tumor tissue correlates with a poor prognosis for disease progression. Concentrations of isoflavonoids that may be achieved in individuals consuming a high-soy diet may inhibit SULT1E1 activity while exerting no effect on steroid sulfatase
-
additional information
-
no effect by 0.1-1.0% v/v ethanol
-
additional information
-
no inhibition by hydroxybenzoic acid, while butylparaben blocks the skin cytosol sulfation of estradiol and estrone, but not the androgen dehydroepiandrosterone. Structure-activity-relationship of parabens as inhibitors of estrogen sulfation, potency of SULT inhibition increases as the paraben ester chain length increases, overview
-
additional information
not inhibited by isoleoheterin, (-)-8n-acetoxy-15,16-epoxy-8,9-seco-13(16),14-labdadiene-7,9-dione, (-) hispanolone, (+)-leoheterin, (+)-galeopsin, and (+)-sibiricinone B
-
additional information
hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1 (EC 2.8.2.2). No inhibition by 4-chloro-4'-hydroxybiphenylsulfate, 2,4'-dichloro-4-hydroxybiphenylsulfate, 3,3'-dichloro-4-hydroxybiphenylsulfate, and 2,2',5,5'-tetrachloro-4-hydroxybiphenylsulfate at up to 0.01 mM
-
additional information
-
no inhibition by tributyltin
-
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