Information on EC - neamine transaminase

for references in articles please use BRENDA:EC2.6.1.93
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EC Tree
     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
       neamine transaminase
IUBMB Comments
The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin B, butirosin, neomycin and ribostamycin. Works in combination with EC, paromamine 6-oxidase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces kanamyceticus can also catalyse EC, 2'-deamino-2'-hydroxyneamine transaminase, which leads to production of kanamycin A . The enzyme from the bacterium Streptomyces fradiae can also catalyse EC, leading to production of neomycin C .
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The enzyme appears in viruses and cellular organisms
6'-oxoglucosaminyl:L-glutamate aminotransferase, 6'-oxoparomamine aminotransferase, btrB, glutamate-6'-dehydroparomamine aminotransferase, kacL, Neo-18, neoB, neoN, more
neamine + 2-oxoglutarate = 6'-dehydroparomamine + L-glutamate
show the reaction diagram
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