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Ligand L-glutamic acid

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Basic Ligand Information

Molecular Structure
Picture of L-glutamic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C5H9NO4
L-glutamic acid
WHUUTDBJXJRKMK-VKHMYHEASA-N
 Download
Synonyms:
(2S)-2-aminopentanedioic acid, alpha-L-Glu, Glu, glutamate, glutamic acid, glutaminic acid, L-(+)-glutamic acid, L-Glu, L-glutamate, L- glutamate, L-glutamate[side 2], L-glutamic acid[side 2]

Related pathways

Pathway Source
Pathways
BRENDA
(S)-reticuline biosynthesis, alanine metabolism, arachidonic acid metabolism, arginine metabolism, aspartate and asparagine metabolism more
KEGG
2-Oxocarboxylic acid metabolism, ABC transporters, Alanine, aspartate and glutamate metabolism, Alcoholism, Aminoacyl-tRNA biosynthesis more
MetaCyc
(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis, (R)-cysteate degradation, (S)-reticuline biosynthesis I, (S)-reticuline biosynthesis II, 2'-deoxymugineic acid phytosiderophore biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for L-glutamic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (181 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+
show the reaction diagram
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2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+
show the reaction diagram
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L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram
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L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2
show the reaction diagram
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L-glutamate + H2O + O2 = 2-oxopentanedioate + NH3 + H2O2
show the reaction diagram
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2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+
show the reaction diagram
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methylamine + L-glutamate = NH3 + N-methyl-L-glutamate
show the reaction diagram
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5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
show the reaction diagram
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acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate
show the reaction diagram
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N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate
show the reaction diagram
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5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
show the reaction diagram
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O-phospho-L-serine + L-glutamate = N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate
show the reaction diagram
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2 S-adenosyl-L-methionine + glutamate = 2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
show the reaction diagram
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(3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate = (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
show the reaction diagram
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dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + L-glutamate = dTDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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8-dehydro-3-deoxy-D-manno-octulosonic acid + L-glutamate = 8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
show the reaction diagram
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N-acetyl-L-glutamic gamma-semialdehyde + L-glutamate = N2-acetyl-L-ornithine + 2-oxoglutarate
show the reaction diagram
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UDP-N-acetyl-3-dehydro-alpha-D-glucosamine + L-glutamate = UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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an [amino-group carrier protein]-C-terminal-[gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate] + L-glutamate = an [amino-group carrier protein]-C-terminal-[gamma-(L-ornithyl)-L-glutamate] + 2-oxoglutarate
show the reaction diagram
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N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate = N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
show the reaction diagram
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imidazol-5-yl-pyruvate + L-glutamate = histidine + 2-oxoglutarate
show the reaction diagram
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glyoxylate + L-glutamate = glycine + 2-oxoglutarate
show the reaction diagram
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3-methyl-2-oxobutyrate + L-glutamate = L-valine + 2-oxoglutarate
show the reaction diagram
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L-2-amino-4-oxobutanoate + L-glutamate = L-2,4-diaminobutanoate + 2-oxoglutarate
show the reaction diagram
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3-methyl-2-oxobutanoate + L-glutamate = L-valine + 2-oxoglutarate
show the reaction diagram
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4-hydroxyphenylglyoxylate + L-glutamate = D-4-hydroxyphenylglycine + 2-oxoglutarate
show the reaction diagram
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prephenate + L-glutamate = L-arogenate + 2-oxoglutarate
show the reaction diagram
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L-glutamate + tetrahydrodipicolinate + H2O = LL-diaminopimelate + 2-oxoglutarate
show the reaction diagram
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UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate = UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
show the reaction diagram
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3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate = L-histidinol phosphate + 2-oxoglutarate
show the reaction diagram
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dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-glutamate = dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-oxoglutarate
show the reaction diagram
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UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate = UDP-4-amino-4,6-dideoxy-L-N-acetyl-beta-L-altrosamine + 2-oxoglutarate
show the reaction diagram
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dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate = dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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L-glutamate = D-glutamate
show the reaction diagram
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L-glutamate = 3-aminopentanedioate
show the reaction diagram
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Glu = ?
show the reaction diagram
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ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu
show the reaction diagram
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ATP + L-glutamate + tRNAGln = AMP + diphosphate + glutamyl-tRNAGln
show the reaction diagram
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ATP + L-glutamate + tRNAAsp = AMP + diphosphate + L-glutamyl-tRNAAsp
show the reaction diagram
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ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate
show the reaction diagram
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ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine
show the reaction diagram
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ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine
show the reaction diagram
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ATP + L-glutamate + histamine = products of ATP breakdown + Nalpha-gamma-L-glutamylhistamine
show the reaction diagram
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ATP + coenzyme gamma-F420-2 + L-glutamate = ADP + phosphate + coenzyme alpha-F420-3
show the reaction diagram
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ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate
show the reaction diagram
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ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + L-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
show the reaction diagram
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ATP + UDP-N-acetylmuramoyl-L-Ala + Glu = ?
show the reaction diagram
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ATP + citrate + L-glutamate = ADP + phosphate + N-citryl-L-glutamate
show the reaction diagram
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ATP + [LysW]-C-terminal-L-glutamate + L-glutamate = ADP + phosphate + [LysW]-C-terminal-gamma-(L-glutamyl)-L-glutamate
show the reaction diagram
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ATP + tyramine + L-glutamate = ADP + phosphate + gamma-glutamyltyramine
show the reaction diagram
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ATP + H2O + L-Glu/out = ADP + phosphate + L-Glu/in
show the reaction diagram
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ATP + H2O + glutamate/out = ADP + phosphate + glutamate/in
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (223 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoglutarate + NH3 + NADH = L-glutamate + H2O + NAD+
show the reaction diagram
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L-saccharopine + H2O + O2 = L-2-aminoadipate 6-semialdehyde + L-glutamate + H2O2
show the reaction diagram
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N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor
show the reaction diagram
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kanosamine 6-phosphate + 2-oxoglutarate = 3-dehydro-D-glucose 6-phosphate + L-glutamate
show the reaction diagram
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(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate
show the reaction diagram
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(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate
show the reaction diagram
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6-aminohexanoate + 2-oxoglutarate = 6-oxohexanoate + L-glutamate
show the reaction diagram
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L-arginine + 2-oxoglutarate = 5-guanidino-2-oxopentanoate + L-glutamate
show the reaction diagram
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L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
show the reaction diagram
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L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
show the reaction diagram
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(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate
show the reaction diagram
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4-hydroxy-L-glutamate + oxo acid = 4-hydroxy-2-oxoglutarate + L-glutamate
show the reaction diagram
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3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
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L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
show the reaction diagram
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L-cysteine + 2-oxoglutarate = L-glutamate + beta-mercaptopyruvate
show the reaction diagram
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L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
show the reaction diagram
639974, -
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L-serine + 2-oxoglutarate = 3-hydroxypyruvate + L-glutamate
show the reaction diagram
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L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
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taurine + 2-oxoglutarate = 2-sulfoacetaldehyde + L-glutamate
show the reaction diagram
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dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
show the reaction diagram
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6-acetamido-3-aminohexanoate + 2-oxoglutarate = 6-acetamido-3-oxohexanoate + L-glutamate
show the reaction diagram
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S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate = S-(4-bromophenyl)-3-thiopyruvate + L-glutamate
show the reaction diagram
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L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate
show the reaction diagram
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L-arogenate + 2-oxoglutarate = L-glutamate + prephenate
show the reaction diagram
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nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate
show the reaction diagram
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putrescine + 2-oxoglutarate = 1-pyrroline + L-glutamate + H2O
show the reaction diagram
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chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
show the reaction diagram
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chorismate + L-glutamine = (2S)-2-amino-4-deoxychorismate + L-glutamate
show the reaction diagram
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dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
show the reaction diagram
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L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
show the reaction diagram
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L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA
show the reaction diagram
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UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate = UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate
show the reaction diagram
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2-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate
show the reaction diagram
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Glu-Leu + H2O = Glu + Leu
show the reaction diagram
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Glu-Leu + H2O = Glu + Leu
show the reaction diagram
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Glu-p-nitroanilide + H2O = glutamic acid + p-nitroaniline
show the reaction diagram
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Glu-plasminogen + H2O = Glu + plasmin
show the reaction diagram
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(S,S)-gamma-glutamyl-(cis-S-1-propenyl)-thioglycine + H2O = (S)-(cis-S-1-propenyl)thioglycine + L-glutamate
show the reaction diagram
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S-(hercyn-2-yl)-gamma-L-glutamyl-L-cysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate
show the reaction diagram
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N5-phenyl-L-glutamine + H2O = L-glutamate + aniline
show the reaction diagram
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L-glutamine + H2O = L-glutamate + NH3
show the reaction diagram
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N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine
show the reaction diagram
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N-formyl-L-glutamate + H2O = formate + L-glutamate
show the reaction diagram
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4-(gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate
show the reaction diagram
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N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide
show the reaction diagram
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D-glutamate = L-glutamate
show the reaction diagram
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D-glutamate = L-glutamate
show the reaction diagram
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ADP + phosphate + beta-citryl-L-glutamate = ATP + citrate + L-glutamate
show the reaction diagram
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ATP + deamido-NAD+ + glutamine = AMP + diphosphate + glutamate + NAD+
show the reaction diagram
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ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate
show the reaction diagram
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ATP + Ni-sirohydrochlorin + L-glutamine + H2O = ADP + phosphate + Ni-sirohydrochlorin a,c-diamide + L-glutamate
show the reaction diagram
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ATP + H2O + glutamate/out = ADP + phosphate + glutamate/in
show the reaction diagram
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ATP + H2O + L-glutamate-[amino acid-binding protein][side 2] = ADP + phosphate + L-glutamate[side 2] + [amino acid-binding protein][side 2]
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (843 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-acetamido-2-deoxy-alpha-D-glucuronic acid + NAD+ + L-glutamate = UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronic acid + NADH + 2-ketoglutarate
show the reaction diagram
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3-deoxy-alpha-D-manno-octulopyranosonate + O2 + L-Glu = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2
show the reaction diagram
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L-glutamate + O2 = 2-oxopentanedioic acid + NH3
show the reaction diagram
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L-glutamate + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-glutamate + succinate + CO2
show the reaction diagram
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L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+
show the reaction diagram
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2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+
show the reaction diagram
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L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
show the reaction diagram
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L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH
show the reaction diagram
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L-glutamate + H2O + O2 = 2-oxopentanedioate + NH3 + H2O2
show the reaction diagram
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benzoyl-CoA + L-glutamic acid = CoA + N-benzoyl-L-glutamic acid
show the reaction diagram
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benzoyl-CoA + glutaminic acid = CoA + N-benzoylglutamic acid
show the reaction diagram
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L-arginyl-tRNAArg + L-glutamic acid = tRNAArg + L-Arg-L-Glu
show the reaction diagram
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5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
show the reaction diagram
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2 S-adenosyl-L-methionine + glutamate = 2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
show the reaction diagram
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L-glutamic acid + KCN = ?
show the reaction diagram
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(3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate = (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
show the reaction diagram
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dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + L-glutamate = dTDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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8-dehydro-3-deoxy-D-manno-octulosonic acid + L-glutamate = 8-amino-3,8-dideoxy-D-manno-octulosonic acid + 2-oxoglutarate
show the reaction diagram
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dTDP-2,6-dideoxy-alpha-D-threo-hexopyranos-4-ulose + L-glutamate = dTDP-4-amino-2,4,6-trideoxy-alpha-D-arabino-hexopyranose + 2-oxoglutarate
show the reaction diagram
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pyruvate + L-glutamate = L-alanine + 2-oxoglutarate
show the reaction diagram
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UDP-N-acetyl-3-dehydro-alpha-D-glucosamine + L-glutamate = UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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an [amino-group carrier protein]-C-terminal-[gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate] + L-glutamate = an [amino-group carrier protein]-C-terminal-[gamma-(L-ornithyl)-L-glutamate] + 2-oxoglutarate
show the reaction diagram
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L-glutamate + 2-oxoarginine = ?
show the reaction diagram
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L-asparagine + L-glutamate = 2-oxosuccinamate + L-glutamine
show the reaction diagram
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N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate = N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
show the reaction diagram
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L-glutamate + 4,5-dioxopentanoate = 5-aminolevulinate + 2-oxoglutarate
show the reaction diagram
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L-glutamate + glyoxylate = 2-oxoglutarate + glycine
show the reaction diagram
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L-2-amino-4-oxobutanoate + L-glutamate = L-2,4-diaminobutanoate + 2-oxoglutarate
show the reaction diagram
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3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate = 3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate
show the reaction diagram
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glutamic acid + 3-hydroxypyruvate = 2-oxo-1,5-pentandioate + serine
show the reaction diagram
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L-glutamate + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol = 5-amino-2,5-dioxopentanoic acid + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
show the reaction diagram
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L-glutamate + glyoxylate = 2-oxoglutarate + glycine
show the reaction diagram
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L-glutamate + phenylpyruvate = 2-oxoglutarate + L-phenylalanine
show the reaction diagram
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3-methyl-2-oxobutanoate + L-glutamate = L-valine + 2-oxoglutarate
show the reaction diagram
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4-hydroxyphenylglyoxylate + L-glutamate = D-4-hydroxyphenylglycine + 2-oxoglutarate
show the reaction diagram
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prephenate + L-glutamate = L-arogenate + 2-oxoglutarate
show the reaction diagram
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UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate = UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
show the reaction diagram
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dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-glutamate = dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-oxoglutarate
show the reaction diagram
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UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate = UDP-4-amino-4,6-dideoxy-L-N-acetyl-beta-L-altrosamine + 2-oxoglutarate
show the reaction diagram
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6'-dehydroparomamine + L-glutamate = neamine + 2-oxoglutarate
show the reaction diagram
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2'-deamino-2'-hydroxyparomamine + L-glutamate = 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate
show the reaction diagram
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2-oxohexanoate + L-glutamate = norleucine + 2-oxoglutarate
show the reaction diagram
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dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate = dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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acetyl-CoA + L-glutamate = coenzyme A + N-acetyl-L-glutamate
show the reaction diagram
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L-glutamic acid + H2O = ?
show the reaction diagram
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L-glutamate + ethylamine = N5-ethyl-L-glutamine + H2O
show the reaction diagram
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L-Glu = ?
show the reaction diagram
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L-glutamate = 4-aminobutyric acid + CO2
show the reaction diagram
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Glu = 4-Aminobutanoate + CO2
show the reaction diagram
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L-Glu + H2O = ?
show the reaction diagram
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L-glutamate = ?
show the reaction diagram
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L-Glu = D-Glu
show the reaction diagram
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L-glutamate = 3-aminopentanedioate
show the reaction diagram
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ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu
show the reaction diagram
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ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu
show the reaction diagram
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ATP + L-glutamate + tRNALys = AMP + L-glutamyl-tRNALys + diphosphate
show the reaction diagram
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ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate
show the reaction diagram
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ATP + deamido-NAD+ + Glu = AMP + diphosphate + NAD+ + 2-oxoglutarate
show the reaction diagram
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ATP + L-glutamate + histamine = products of ATP breakdown + Nalpha-gamma-L-glutamylhistamine
show the reaction diagram
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ATP + L-tyrosine + glutamate = ? + AMP
show the reaction diagram
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L-glutamate + L-cysteine + L-valine + ATP = L-glutamyl-L-cysteinyl-D-valine + AMP + diphosphate
show the reaction diagram
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ATP + gamma-L-glutamyl-L-cysteine + L-Glu = ?
show the reaction diagram
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ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate
show the reaction diagram
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ATP + [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate + L-glutamate = ADP + phosphate + [lysine-biosynthesis-protein LysW]-C-terminal-gamma-(L-glutam-2-yl)-L-glutamate
show the reaction diagram
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ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + L-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
show the reaction diagram
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ATP + citrate + L-glutamate = ADP + phosphate + N-citryl-L-glutamate
show the reaction diagram
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ATP + [LysW]-C-terminal-L-glutamate + L-glutamate = ADP + phosphate + [LysW]-C-terminal-gamma-(L-glutamyl)-L-glutamate
show the reaction diagram
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ATP + alpha-tubulin + L-glutamate = L-glutamyl-alpha-tubulin + ADP + phosphate
show the reaction diagram
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ATP + tyramine + L-glutamate = ADP + phosphate + gamma-glutamyltyramine
show the reaction diagram
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glutamate = ?
show the reaction diagram
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ATP + H2O + glutamate/out = ADP + phosphate + glutamate/in
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1120 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoglutarate + NH3 + NADH + H+ = L-glutamate + H2O + NAD+
show the reaction diagram
-
-
methylamine + alpha-ketobutyrate + NADPH = glutamic acid + H2O + NADP+
show the reaction diagram
-
-
2-oxoglutarate + NH3 + NAD(P)H + H+ = L-glutamate + H2O + NAD(P)+
show the reaction diagram
-
-
L-saccharopine + H2O + O2 = L-2-aminoadipate 6-semialdehyde + L-glutamate + H2O2
show the reaction diagram
-
-
L-ornithine + N-acetyl-L-glutamate = N2-acetyl-L-ornithine + L-glutamate
show the reaction diagram
-
-
(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = (3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate
show the reaction diagram
-
-
kanosamine 6-phosphate + 2-oxoglutarate = 3-dehydro-D-glucose 6-phosphate + L-glutamate
show the reaction diagram
-
-
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate
show the reaction diagram
-
-
6-aminohexanoate + 2-oxoglutarate = 6-oxohexanoate + L-glutamate
show the reaction diagram
-
-
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
show the reaction diagram
-
L-arginine + 2-oxoglutarate = 5-guanidino-2-oxopentanoate + L-glutamate
show the reaction diagram
-
-
2-oxosuccinamic acid + L-glutamine = L-asparagine + L-glutamate
show the reaction diagram
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-
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
show the reaction diagram
-
N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
show the reaction diagram
-
-
D-histidine + 2-oxoglutarate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
L-tryptophan + 2-oxoglutarate = 3-indole-2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
pyridoxamine + 2-oxoglutarate = pyridoxal + L-glutamate
show the reaction diagram
-
-
TDP-4-amino-4,6-dideoxy-alpha-D-glucose + 2-oxoglutarate = TDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
show the reaction diagram
-
-
alpha-ketoglutarate + L-alanine = L-glutamate + pyruvate
show the reaction diagram
-
histidine + 2-oxoglutarate = imidazol-5-yl-pyruvate + L-glutamate
show the reaction diagram
-
-
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
show the reaction diagram
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-
D-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutanoate + L-glutamate
show the reaction diagram
-
L-serine + 2-oxoglutarate = 3-hydroxypyruvate + L-glutamate
show the reaction diagram
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-
L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate
show the reaction diagram
-
-
L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate
show the reaction diagram
-
-
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
show the reaction diagram
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-
L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate
show the reaction diagram
-
-
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
show the reaction diagram
-
-
L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate
show the reaction diagram
-
-
6-acetamido-3-aminohexanoate + 2-oxoglutarate = 6-acetamido-3-oxohexanoate + L-glutamate
show the reaction diagram
636994, -
-
L-methionine + 2-oxoglutarate = 4-methylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
-
-
D-alanine + 2-oxoglutarate = pyruvate + L-glutamate
show the reaction diagram
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taurine + 2-oxoglutarate = 2-sulfoacetaldehyde + L-glutamate
show the reaction diagram
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-
2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate
show the reaction diagram
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nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate
show the reaction diagram
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-
L-methionine + 2-oxoglutarate = 2-oxo-4-methylthiobutanoate + L-glutamate
show the reaction diagram
-
-
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
show the reaction diagram
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L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA
show the reaction diagram
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UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate = UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate
show the reaction diagram
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(S)-1-phenylethylamine + 2-oxoglutarate = acetophenone + L-glutamate
show the reaction diagram
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Glu-tRNA + H2O = Glu + tRNA
show the reaction diagram
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glutaryl-7-aminocephalosporanic acid + H2O = 7-aminocephalosporanic acid + glutamate
show the reaction diagram
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-
L-glutamic acid methyl ester + H2O = L-glutamic acid + methanol
show the reaction diagram
-
L-gamma-glutamine-4-nitroanilide + H2O = L-glutamate + 4-nitroaniline
show the reaction diagram
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-
L-glutamate-7-amido-4-methylcoumarin + H2O = L-glutamate + 7-amino-4-methylcoumarin
show the reaction diagram
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Ala-Glu + H2O = Ala + Glu
show the reaction diagram
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L-glutamate 4-nitroanilide + H2O = L-glutamate + 4-nitroaniline
show the reaction diagram
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Glu-Leu + H2O = Glu + Leu
show the reaction diagram
-
Glu-4-nitroanilide + H2O = Glu + 4-nitroaniline
show the reaction diagram
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-
Met-Glu + H2O = Met + Glu
show the reaction diagram
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-
L-Ala-L-Glu + H2O = L-Ala + L-Glu
show the reaction diagram
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L-Glu-L-Trp + H2O = L-glutamate + L-tryptophan
show the reaction diagram
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N-acetyl-L-Glu + H2O = L-Glu + acetate
show the reaction diagram
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Glu-Glu + H2O = Glu + Glu
show the reaction diagram
-
L-Pro-L-Glu + H2O = L-Pro + L-Glu
show the reaction diagram
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-
Ser-Met-Glu + H2O = Ser-Met + Glu
show the reaction diagram
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Ser-Met-Glu + H2O = Ser-Met + Glu
show the reaction diagram
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-
6-aminoquinoline-N-hydroxysuccimidyl carbamoyl-L-Tyr-Gly-L-Leu-L-Phe-L-Glu + H2O = 6-aminoquinoline-N-hydroxysuccimidyl carbamoyl-L-Tyr-Gly-L-Leu-L-Phe + L-Glu
show the reaction diagram
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hippuryl-L-Glu + H2O = hippuric acid + Glu
show the reaction diagram
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Glu-plasminogen + H2O = Glu + plasmin
show the reaction diagram
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benzyloxycarbonyl-Gly-Glu + H2O = benzyloxycarbonyl-Gly + Glu
show the reaction diagram
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Glu-Ala + H2O = Glu + Ala
show the reaction diagram
-
L-Bz-Glu + H2O = benzoic acid + L-glutamate
show the reaction diagram
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acetyl-Met-Glu + H2O = acetyl-Met + Glu
show the reaction diagram
-
leukotriene C4 + H2O = leukotriene D4 + L-glutamate
show the reaction diagram
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-
pyroglutamyl-Glu + H2O = pyroglutamate + Glu
show the reaction diagram
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L-gamma-glutamyl-4-nitroanilide + H2O = L-glutamate + 4-nitroaniline
show the reaction diagram
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VLLVSEVL + 3 H2O = VLLV + Ser + Glu + VL
show the reaction diagram
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N-benzyloxycarbonyl-Gly-Pro-Glu + H2O = N-benzyloxycarbonyl-Gly-Pro + L-Glu
show the reaction diagram
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Glu-4-methylcoumarin 7-amide + H2O = Glu + 7-amino-4-methylcoumarin
show the reaction diagram
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L-Glu-7-amido-4-methylcoumarin + H2O = L-Glu + 7-amino-4-methylcoumarin
show the reaction diagram
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Thr-Ile-Asp-Glu + H2O = Thr-Ile-Asp + Glu
show the reaction diagram
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L-glutamine amide + H2O = L-glutamic acid + NH3
show the reaction diagram
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-
N-phenylacetyl-Glu + H2O = phenylacetic acid + Glu
show the reaction diagram
-
S-(hercyn-2-yl)-gamma-L-glutamyl-L-cysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate
show the reaction diagram
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N5-phenyl-L-glutamine + H2O = L-glutamate + aniline
show the reaction diagram
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N5-(cytidine 5'-diphosphoramidyl)-L-glutamine + H2O = cytidine 5'-diphosphoramidate + L-glutamate
show the reaction diagram
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-
L-Glu-beta-naphthylamide + H2O = Glu + beta-naphthylamine
show the reaction diagram
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L-isoglutamine + H2O = L-glutamate + NH3
show the reaction diagram
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L-glutamine + H2O = L-glutamate + NH3
show the reaction diagram
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-
L-Gln + H2O = L-Glu + NH3
show the reaction diagram
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L-Gln + H2O = L-Glu + NH3
show the reaction diagram
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L-glutamine + H2O = L-glutamate + NH3
show the reaction diagram
81203, -
-
L-glutamine + H2O = L-glutamate + NH3
show the reaction diagram
172073, -
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N-carbamoyl-L-glutamic acid + H2O = L-glutamic acid + CO2 + NH3
show the reaction diagram
209293, -
-
N-succinyl-L-glutamate + H2O = succinate + L-glutamate
show the reaction diagram
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DL-5-(2-carboxyethyl)hydantoin + H2O = L-glutamic acid
show the reaction diagram
-
N-amidino-L-glutamate + H2O = L-glutamic acid + urea
show the reaction diagram
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-
N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide
show the reaction diagram
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L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartic beta-semialdehyde + L-glutamic acid
show the reaction diagram
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5-L-glutamyl-L-glutamate = 5-oxoproline + L-glutamate
show the reaction diagram
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2-oxoglutarate + L-ornithine = D-glutamate + L-glutamate
show the reaction diagram
-
ADP + phosphate + beta-citryl-L-glutamate = ATP + citrate + L-glutamate
show the reaction diagram
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ADP + phosphate + L-glutamine = ATP + L-glutamate + NH3
show the reaction diagram
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ATP + 4-methylene-L-glutamate + glutamine = AMP + diphosphate + glutamate + 4-methylene-L-glutamine
show the reaction diagram
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2 ATP + L-Gln + HCO3- = 2 ADP + phosphate + L-Glu + carbamoyl phosphate
show the reaction diagram
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ATP + ribose 5-phosphate + Gln = ADP + phosphate + 5-phosphoribosylamine + Glu
show the reaction diagram
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ATP + Ni-sirohydrochlorin + L-glutamine + H2O = ADP + phosphate + Ni-sirohydrochlorin a,c-diamide + L-glutamate
show the reaction diagram
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ATP + H2O + glutamate/out = ADP + phosphate + glutamate/in
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (34 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
increased uptake leads to activation
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stimulation, 166% of non-stimulated activity
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activation
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glutamate remodels the sigma38 transcription complex for activation. Accumulation of the simple signaling molecule glutamate can reprogram RNA polymerase in vitro without the need for specific protein receptors. During osmotic activation, glutamate appears to act as a Hofmeister series osmolyte to facilitate promoter escape. Escape is accompanied by a remodeling of the key interaction between the sigma38 stress protein and the beta-flap of the bacterial core RNA polymerase. This activation event contrasts with the established mechanism of inhibition in which glutamate, by virtue of its electrostatic properties, helps to inhibit binding to ribosomal promoters after osmotic shock
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stimulates activity
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extends salt concentration range
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activates
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the shedding activity of the enzyme is increased during glutamate stimulation
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activation and induction
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activation of ATP hydrolysis, no activation of ADP hydrolysis
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stimulates
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slight stimulation
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activates
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activation is abolished by the simultaneous addition of cycloheximide
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presence of glutamate increases the ALAD activity in the in vitro enzymatic preparations obtained from the sorbitolx02treated leaf segments
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3fold activation of tagless recombinant enzyme
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5 mM, 143% of initial L-proline uptake
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Inhibitor in Enzyme-catalyzed Reactions (237 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
both directions
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80% inhibition of isozyme ICDH2 at 2 mM
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57% inhibition at 5 mM with catechol as substrate
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84% inhibition at 30 mM
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42% inhibition at 5 mM
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20% inhibition at 2.5 mM
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68% inhibition at 10 mM glutamic acid in the growth medium
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neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
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IVD transcription is strongly repressed by L-glutamate
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89.3% residual activity at 1 mM
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slight inhibition at 100 mM
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exhibits noncompetitive inhibition versus NADP+ and saccharopine
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3 mM, 40% loss of activity
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product inhibition
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inhibition is reversible, dose-dependent, no inhibition of mRNA expression
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Glutamate is a competitive inhibitor. No inhibition is observed with other amino acids, indicating that the enzyme is specific.
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competitive vs. glutamate
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weak, asparagine/pyruvate reaction
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inhibits activity towards tryptophan
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inhibition of transamination by the oxo substrate at above 200 mM
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competitive to tyrosine
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L- and D-isomer
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20 mM, 40% inhibition
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inhibitor of isozyme PP2A
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isoenzyme II, french bean
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competitive
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at micromolar concentrations
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product inhibition of enzyme Lc-PepA, 8.4% inhibition at 0.1 mM, 17.7% at 10 mM, product inhibition versus substrate L-Asp-4-nitroanilide, and 1.47% inhibition at 0.1 mM, 31.4% at 10 mM, product inhibition versus substrate L-Glu-4-nitroanilide
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inhibition by displacement of viral DNA from complexes with enzyme
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competitive
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0.002 M, 20-25% inhibition
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competitive inhibition
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competitive inhibition, Ki: glutaminase acitvity 5 mM, asparaginase activity 3 mM
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strong inhibition, 0.7 mM: 86%, 3.3 mM: 58%, 8 mM: 56%, 53.3 mM: 25% of activity compared to H2O
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non-competitive, Ki: 5.4 mM
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competitive inhibition, 10 mM
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liver enzyme
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reaction of component I with NH4+ as substrate
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about 20% inhibition at 1 mM when using isocitrate as substrate
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40 mM, 23% inhibition
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the enzyme activity decreases to 85% in presence of 10 mM L-Glu
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weak
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excess L-glutamate reduced in vivo synthesis of meso-diaminoheptanedioate by Chlamydia trachomatis to undetectable levels. Excess racemase substrate leads to inhibition of DapFCt diaminopimelate epimerase activity
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regulates the activity of topo I in mouse cerebellum sections. Exhibits a significant time-dependent inhibition of topo I activity but no effect of the enzyme protein level
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competitive inhibition of the wild-type and mutant enzymes
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with NH4+ is nitrogen donor
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56% inhibition at 2.5 mM
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competitive wih respect to L-glutamine transport
-

3D Structure of Enzyme-Ligand-Complex (PDB) (386 results)

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EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (308 results)

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EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3.67
-
L-glutamate:iodonitrotetrazolium oxidoreductase activity at pH 9.5
0.22
-
-
0.023
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pH 7.4, temperature not specified in the publication
0.005
-
pH not specified in the publication, temperature not specified in the publication
2.49
-
pH 9.0, 30°C
10.3
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pH 7.4, 25°C, recombinant enzyme, with cosubstrate alpha-aminoadipate
0.03
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pH 8.0, 25°C
200
-
pH 8.0, 30°C
12.8
-
at pH 7.4 and 25°C
1.5
-
pH 8.0, 30°C
1.7
-
-

KM Value (900 results)

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EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.001
-
pH 8.5, 45°C, GltA and GltA2
0.044
-
L-glutamate:iodonitrotetrazolium oxidoreductase activity at pH 9.5
1150
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acyl donor benzoyl-CoA
1148
-
-
0.42
-
pH not specified in the publication, temperature not specified in the publication
2
5
at pH 8.3 and 30°C
25
-
-
33
-
pH 8.1, 37°C
5.1
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38°C, pH 7.0-7.6
5
-
pH 8.0, 30°C
4.1
-
pH 8.0, 30°C
7.9
-
pH 7.0, 38°C
21
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pH 8.0, 25°C
5.6
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pH 8.0, 37°C, alpha-aminoadipate aminotransferase activity
9.1
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pH 8.5, 25°C
2.8
-
only for N-acetylglutamate synthase activity
2.9
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brain enzyme
5.3
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mutant enzyme R100T/V283R
240
-
mutant C229R GlnRS, with tRNAGln
2.07
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pH 8.0 37°C, recombinant enzyme
0.73
-
pH 8.0, 30°C
4.6
-
-
10.6
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at pH 8.0 and 37°C
0.73
-
pH 8.0, 30°C
0.0002
-
-

Ki Value (67 results)

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EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.079
-
-
1.5
-
-
5.6
-
competitive inhibitor
0.9
-
-
6.1
-
-
30
-
-
7.42
-
pH 7.5, 30°C
0.2
0.5
wild-type enzyme
128
-
pH 8.0, 25°C, aspartokinase III
0.12
-
pH 7.5, 30°C
0.00023
-
37°C, pH 8.0
-999
-
39.0 mol/l, pH and temperature not specified in this publication
5.4
-
non-competitive

IC50 Value (17 results)

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EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.9
-
IC50: 0.9 mM
32
-
Hill coefficient 0.9, pH 7, 30°C

References & Links

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