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Information on EC 2.6.1.107 - beta-methylphenylalanine transaminase

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EC Tree

2 Transferases

2.6 Transferring nitrogenous groups

2.6.1 Transaminases

2.6.1.107 beta-methylphenylalanine transaminase

IUBMB Comments

Requires pyridoxal phosphate. Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.

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The enzyme appears in viruses and cellular organisms

Reaction Schemes

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(2S,3S)-3-methylphenylalanine

2-oxoglutarate

(3S)-2-oxo-3-phenylbutanoate

L-glutamate

Synonyms

TyrB,

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

TyrB

2 entries

TyrB

Streptomyces hygroscopicus

Q643C8

722038

TyrB

Streptomyces hygroscopicus NRRL3085

Q643C8

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate

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SYSTEMATIC NAME

IUBMB Comments

(2S,3S)-3-methylphenylalanine:2-oxoglutarate aminotransferase

Requires pyridoxal phosphate. Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(2S,3S)-3-methylphenylalanine + 2-oxoglutarate

(3S)-2-oxo-3-phenylbutanoate + L-glutamate

4 entries

(2S,3S)-3-methylphenylalanine + 2-oxoglutarate

(3S)-2-oxo-3-phenylbutanoate + L-glutamate

Streptomyces hygroscopicus

Q643C8

722038

(2S,3S)-3-methylphenylalanine + 2-oxoglutarate

(3S)-2-oxo-3-phenylbutanoate + L-glutamate

Streptomyces hygroscopicus

Q643C8

the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin

722038

(2S,3S)-3-methylphenylalanine + 2-oxoglutarate

(3S)-2-oxo-3-phenylbutanoate + L-glutamate

Streptomyces hygroscopicus NRRL3085

Q643C8

722038

(2S,3S)-3-methylphenylalanine + 2-oxoglutarate

(3S)-2-oxo-3-phenylbutanoate + L-glutamate

Streptomyces hygroscopicus NRRL3085

Q643C8

the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin

722038

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(2S,3S)-3-methylphenylalanine + 2-oxoglutarate

(3S)-2-oxo-3-phenylbutanoate + L-glutamate

2 entries

(2S,3S)-3-methylphenylalanine + 2-oxoglutarate

(3S)-2-oxo-3-phenylbutanoate + L-glutamate

Streptomyces hygroscopicus

Q643C8

the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin

722038

(2S,3S)-3-methylphenylalanine + 2-oxoglutarate

(3S)-2-oxo-3-phenylbutanoate + L-glutamate

Streptomyces hygroscopicus NRRL3085

Q643C8

the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin

722038

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

pyridoxal 5'-phosphate

Streptomyces hygroscopicus

Q643C8

required

722038

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Streptomyces hygroscopicus

Q643C8

assay at

722038

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TEMPERATURE OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Streptomyces hygroscopicus

Q643C8

assay at

722038

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Streptomyces hygroscopicus

722038

Q643C8

SwissProt

brenda

Streptomyces hygroscopicus NRRL3085

722038

Q643C8

SwissProt

brenda

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

2 entries

physiological function

Streptomyces hygroscopicus

Q643C8

the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin

722038

physiological function

Streptomyces hygroscopicus NRRL3085

the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

P04693 pBLAST

TYRB_ECOLI

Escherichia coli (strain K12)

397

43538

Swiss-Prot

Show Sequence

A0A259UBR0 pBLAST

A0A259UBR0_9FIRM

Sporomusa acidovorans DSM 3132

415

45620

TrEMBL

Show Sequence

A0A259UJ70 pBLAST

A0A259UJ70_9FIRM

Sporomusa silvacetica DSM 10669

418

46186

TrEMBL

Show Sequence

A0A2C8CWY0 pBLAST

A0A2C8CWY0_9GAMM

Sodalis endosymbiont of Henestaris halophilus

398

44437

TrEMBL

Show Sequence

A0A1J5SP93 pBLAST

A0A1J5SP93_9ZZZZ

mine drainage metagenome

406

44126

TrEMBL

Show Sequence

other Location (Reliability: 3)

A0A1U7M9T3 pBLAST

A0A1U7M9T3_9FIRM

Sporomusa sphaeroides DSM 2875

415

45514

TrEMBL

Show Sequence

Q643C8 pBLAST

MPPJ_STRHY

Streptomyces hygroscopicus

337

37186

Swiss-Prot

Show Sequence

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expression in Escherichia coli

Streptomyces hygroscopicus

Q643C8

722038

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

722038

Huang, Y.T.; Lyu, S.Y.; Chuang, P.H.; Hsu, N.S.; Li, Y.S.; Chan, H.C.; Huang, C.J.; Liu, Y.C.; Wu, C.J.; Yang, W.B.; Li, T.L.

In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin

ChemBioChem

2480-2487

2009

Streptomyces hygroscopicus (Q643C8), Streptomyces hygroscopicus NRRL3085 (Q643C8)

19731276

brenda