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IUBMB Comments Requires pyridoxal phosphate. Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.
The enzyme appears in viruses and cellular organisms
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TyrB
-
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(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate
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-
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(2S,3S)-3-methylphenylalanine:2-oxoglutarate aminotransferase
Requires pyridoxal phosphate. Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.
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(2S,3S)-3-methylphenylalanine + 2-oxoglutarate
(3S)-2-oxo-3-phenylbutanoate + L-glutamate
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate
(3S)-2-oxo-3-phenylbutanoate + L-glutamate
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?
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate
(3S)-2-oxo-3-phenylbutanoate + L-glutamate
the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin
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-
?
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate
(3S)-2-oxo-3-phenylbutanoate + L-glutamate
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-
-
?
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate
(3S)-2-oxo-3-phenylbutanoate + L-glutamate
the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate
(3S)-2-oxo-3-phenylbutanoate + L-glutamate
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate
(3S)-2-oxo-3-phenylbutanoate + L-glutamate
the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin
-
-
?
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate
(3S)-2-oxo-3-phenylbutanoate + L-glutamate
the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin
-
-
?
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pyridoxal 5'-phosphate
required
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SwissProt
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SwissProt
brenda
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physiological function
the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin
physiological function
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the enzyme is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin
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TYRB_ECOLI
Escherichia coli (strain K12)
397
0
43538
Swiss-Prot
-
A0A259UBR0_9FIRM
415
0
45620
TrEMBL
-
A0A259UJ70_9FIRM
418
0
46186
TrEMBL
-
A0A2C8CWY0_9GAMM
398
0
44437
TrEMBL
-
A0A1J5SP93_9ZZZZ
406
0
44126
TrEMBL
other Location (Reliability: 3 )
A0A1U7M9T3_9FIRM
415
0
45514
TrEMBL
-
MPPJ_STRHY
337
0
37186
Swiss-Prot
-
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expression in Escherichia coli
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Huang, Y.T.; Lyu, S.Y.; Chuang, P.H.; Hsu, N.S.; Li, Y.S.; Chan, H.C.; Huang, C.J.; Liu, Y.C.; Wu, C.J.; Yang, W.B.; Li, T.L.
In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin
ChemBioChem
10
2480-2487
2009
Streptomyces hygroscopicus (Q643C8), Streptomyces hygroscopicus NRRL3085 (Q643C8)
brenda
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