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Information on EC 2.5.1.142 - nerylneryl diphosphate synthase
for references in articles please use BRENDA:EC2.5.1.142
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EC Tree 2 Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.142 nerylneryl diphosphate synthase
IUBMB Comments
Isolated from the plant Solanum lycopersicum (tomato).
The enzyme appears in viruses and cellular organisms
Reaction Schemes
showSynonyms
cis-prenyl transferase, CPT1, CPT2, NNPP synthase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
cis-prenyl transferase
CPT1
CPT2
NNPP synthase
CPT2
-
-
ambiguous
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
dimethylallyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + nerylneryl diphosphate
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 3 isopentenyl units)
Isolated from the plant Solanum lycopersicum (tomato).
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + nerylneryl diphosphate
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
dimethylallyl diphosphate + Z,Z-farnesyl diphosphate
?
-
Substrates: -
Products: -
Products: -
?
(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + neryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + neryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + neryl diphosphate
-
Substrates: -
Products: -
Products: -
?
neryl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6Z)-farnesyl diphosphate
-
Substrates: -
Products: -
Products: -
?
neryl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6Z)-farnesyl diphosphate
-
Substrates: -
Products: -
Products: -
?
neryl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6Z)-farnesyl diphosphate
-
Substrates: -
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + nerylneryl diphosphate
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate
diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + 3 isopentenyl diphosphate
3 diphosphate + nerylneryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + neryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + neryl diphosphate
-
Substrates: -
Products: -
Products: -
?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + neryl diphosphate
-
Substrates: -
Products: -
Products: -
?
neryl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6Z)-farnesyl diphosphate
-
Substrates: -
Products: -
Products: -
?
neryl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6Z)-farnesyl diphosphate
-
Substrates: -
Products: -
Products: -
?
neryl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6Z)-farnesyl diphosphate
-
Substrates: -
Products: -
Products: -
?
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli EXPRESS BL21 cells
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Akhtar, T.A.; Matsuba, Y.; Schauvinhold, I.; Yu, G.; Lees, H.A.; Klein, S.E.; Pichersky, E.
The tomato cis-prenyltransferase gene family
Plant J.
73
640-652
2013
Solanum lycopersicum (K7WQ45)
brenda
Matsuba, Y.; Zi, J.; Jones, A.D.; Peters, R.J.; Pichersky, E.
Biosynthesis of the diterpenoid lycosantalonol via nerylneryl diphosphate in Solanum lycopersicum
PLoS ONE
10
e0119302
2015
Solanum lycopersicum
brenda
Gericke, O.; Hansen, N.L.; Pedersen, G.B.; Kjaerulff, L.; Luo, D.; Staerk, D.; Moller, B.L.; Pateraki, I.; Heskes, A.M.
Nerylneryl diphosphate is the precursor of serrulatane, viscidane and cembrane-type diterpenoids in Eremophila species
BMC Plant Biol.
20
91
2020
Eremophila denticulata subsp. trisulcata, Eremophila drummondii, Eremophila lucida
brenda
Pelot, K.A.; Hagelthorn, D.M.; Hong, Y.J.; Tantillo, D.J.; Zerbe, P.
Diterpene synthase-catalyzed biosynthesis of distinct clerodane stereoisomers
Chembiochem
20
111-117
2020
Solanum lycopersicum
brenda
EXTERNAL LINKS (specific for EC-Number 2.5.1.142)
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Release 2026.1 (March 2026)
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