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EC Tree
IUBMB Comments Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also use neryl diphosphate as substrate, forming cannabinerolate.
The expected taxonomic range for this enzyme is: Cannabis sativa
Synonyms
geranylpyrophosphate:olivetolate geranyltransferase, GOT,
PT4-T ,
more
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geranylpyrophosphate:olivetolate geranyltransferase
geranylpyrophosphate:olivetolate geranyltransferase
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geranylpyrophosphate:olivetolate geranyltransferase
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GOT
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geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate = diphosphate + cannabigerolate
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geranyl-diphosphate:olivetolate geranyltransferase
Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also use neryl diphosphate as substrate, forming cannabinerolate.
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geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate
diphosphate + cannabigerolate
geranyl diphosphate + olivetolic acid
diphosphate + cannabigerolate
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additional information
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the enzyme accepts geranyldiphosphate and to a lesser degree also neryldiphosphate as a cosubstrate. Olivetol is inactive as a prenyl acceptor, GOT is specific for olivetolic acid
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geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate
diphosphate + cannabigerolate
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geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate
diphosphate + cannabigerolate
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i.e. olivetolate
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geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate
diphosphate + cannabigerolate
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geranyl diphosphate + olivetolic acid
diphosphate + cannabigerolate
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Mg2+
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essentially required
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0.00673
olivetolic acid
at pH 8.5 and 30°C
additional information
additional information
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Michaelis-Menten kinetics with geranyl diphosphate as substrate
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UniProt
brenda
var. Skunk
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young
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metabolism
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GOT is the first enzyme in the biosynthesis of DELTA1-tetrahydrocannabinolic acid and cannabinoids
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A0A455ZJC3_CANSA
398
0
44928
TrEMBL
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Fellermeier, M.; Zenk, M.
Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol
FEBS Lett.
427
283-285
1998
Cannabis sativa
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Luo, X.; Reiter, M.; d'Espaux, L.; Wong, J.; Denby, C.; Lechner, A.; Zhang, Y.; Grzybowski, A.; Harth, S.; Lin, W.; Lee, H.; Yu, C.; Shin, J.; Deng, K.; Benites, V.; Wang, G.; Baidoo, E.; Chen, Y.; Dev, I.; Petzold, C.; Keasling, J.
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast
Nature
567
123-126
2019
Cannabis sativa (A0A455ZJC3), Cannabis sativa
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