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Information on EC - globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

for references in articles please use BRENDA:EC2.4.1.79
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IUBMB Comments
Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity . The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity . UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity . Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates . For explanation of the superscripted '3' in the systematic name, see {iupac/misc/glylp#5.3::GL-5.3.4}.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-glycosphingolipid, beta(1->3) N-acetylgalactosaminyltransferase, beta1,3GalNAc-T, galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase, GalNAc transferase, globoside N-acetylgalactosaminyltransferase, globoside synthetase, glycosphingolipid beta-N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, more
UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
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