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Information on EC 2.4.1.134 - galactosylxylosylprotein 3-beta-galactosyltransferase
for references in articles please use BRENDA:EC2.4.1.134
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EC Tree 2 Transferases
2.4 Glycosyltransferases
2.4.1 Hexosyltransferases
2.4.1.134 galactosylxylosylprotein 3-beta-galactosyltransferase
IUBMB Comments
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 2.4.1.134
- glycosyltransferases
- glycans
-
galts
- arabinogalactan-proteins
-
galactosyltransferases
-
pollen
- rhamnose
- glcnac
-
serine-rich
- streptococcal
- parasanguinis
- lactosylceramide
-
mucilage
-
o-glycosylation
- adhesin
- galnact
-
hemolytic-uremic
-
leloir
-
bacterial-host
-
2.7.7.12
-
srrps
- tetrasaccharide
-
sub-golgi
- arabinogalactans
- longum
- globotriaosylceramide
-
silique
-
hbecs
- alpha-galactosidase
-
uridylyltransferase
-
shiga
- galactose-1-phosphate
Reaction Schemes
showSynonyms
galt2, dbeta3galtii, beta3galt i, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
galactosyltransferase II
galactosyltransferase, uridine diphosphogalactose-galactosylxylose
-
-
-
-
UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
-
-
-
-
galactosyltransferase II
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
MetaCyc
glycosaminoglycan-protein linkage region biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
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CAS REGISTRY NUMBER
COMMENTARY
56626-19-8
-
56626-21-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-galactose + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-galactose + 4-methylumbelliferyl-beta-D-xylopyranoside
UDP + ?
Substrates: -
Products: -
Products: -
?
UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylose
UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylose
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-xylosylprotein
-
Substrates: involved in biosynthesis of chondroitin sulfate
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,3-beta-galactosyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-beta-galactosyl-O-naphthalenemethanol
UDP-galactose + beta-D-galactosyl-1,3-N-acetyl-alpha-D-glucosaminyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-glucosaminyl-O-naphthalenemethanol
UDP-galactose + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,4-beta-D-xylosyl-O-benzyl
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-xylosyl-O-benzyl
UDP-galactose + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
UDP-galactose + beta-D-galactosyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-O-naphthalenemethanol
UDP-galactose + beta-galactosides
?
-
Substrates: e.g. phenyl or pyridine 3-O-beta-galactosides, poor substrate: pyridine 2-S-beta-thiogalactoside, no substrate: D-galactose
Products: -
Products: -
?
UDP-galactose + galactosyl-xylosylserine
UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylserine
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + Galalpha-p-nitrophenol
?
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + Galbeta-p-nitrophenol
?
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + Galbeta1,4Xyl-p-methoxyphenol
?
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-O-naphthalenemethanol
Substrates: -
Products: -
Products: -
?
UDP-galactose + pyridine 3-O-beta-D-galactoside
UDP + ?
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,3-beta-galactosyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-beta-galactosyl-O-naphthalenemethanol
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,3-beta-galactosyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-beta-galactosyl-O-naphthalenemethanol
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,3-beta-galactosyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-beta-galactosyl-O-naphthalenemethanol
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,3-N-acetyl-alpha-D-glucosaminyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-glucosaminyl-O-naphthalenemethanol
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,3-N-acetyl-alpha-D-glucosaminyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-glucosaminyl-O-naphthalenemethanol
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,4-beta-D-xylosyl-O-benzyl
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-xylosyl-O-benzyl
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,4-beta-D-xylosyl-O-benzyl
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-xylosyl-O-benzyl
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,4-beta-D-xylosyl-O-benzyl
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-xylosyl-O-benzyl
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-O-naphthalenemethanol
-
Substrates: -
Products: -
Products: -
?
UDP-galactose + beta-D-galactosyl-O-naphthalenemethanol
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-O-naphthalenemethanol
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: dbeta3GalTII is involved in heparan sulfate synthesis for wing and eye development. dbeta3GalTII contributes to heparan sulfate proteoglycan synthesis in vitro and in vivo and also modulates Wingless distribution
Products: -
Products: -
?
additional information
?
-
-
Substrates: modeling of 3-D structures of human b3GalT I, II, IV, V, and VI using fold-recognition and comparative modeling methods. Prediction of residues that constitute the UDP-Gal binding site. The models are able to qualitatively rationalize data from the site-directed mutagenesis experiments reported in the literature
Products: -
Products: -
?
additional information
?
-
Substrates: modeling of 3-D structures of human b3GalT I, II, IV, V, and VI using fold-recognition and comparative modeling methods. Prediction of residues that constitute the UDP-Gal binding site. The models are able to qualitatively rationalize data from the site-directed mutagenesis experiments reported in the literature
Products: -
Products: -
?
additional information
?
-
Substrates: modeling of 3-D structures of human b3GalT I, II, IV, V, and VI using fold-recognition and comparative modeling methods. Prediction of residues that constitute the UDP-Gal binding site. The models are able to qualitatively rationalize data from the site-directed mutagenesis experiments reported in the literature
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-galactose + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
Substrates: -
Products: -
Products: -
?
UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-xylosylprotein
-
Substrates: involved in biosynthesis of chondroitin sulfate
Products: -
Products: -
?
additional information
?
-
-
Substrates: dbeta3GalTII is involved in heparan sulfate synthesis for wing and eye development. dbeta3GalTII contributes to heparan sulfate proteoglycan synthesis in vitro and in vivo and also modulates Wingless distribution
Products: -
Products: -
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Vesicular Stomatitis
Calsenilin and CALP interact with the cytoplasmic tail of UDP-Gal:GA2/GM2/GD2 beta-1,3-galactosyltransferase.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
18
2660
pmol/h/ml medium, beta-D-galactosyl-1,4-beta-xylosyl-O-benzyl as substrate
3
pmol/h/ml medium, beta-D-galactosyl-1,3-beta-D-galactosyl-O-naphthalenemethanol as substrate
84
1
pmol/h/ml medium, beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol as substrate
1
-
pmol/h/ml medium, beta-D-galactosyl-1,3-beta-D-galactosyl-O-naphthalenemethanol as substrate
1
-
pmol/h/ml medium, beta-D-galactosyl-1,3-beta-D-galactosyl-O-naphthalenemethanol as substrate
4
-
pmol/h/ml medium, beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol as substrate
4
-
pmol/h/ml medium, beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-O-naphthalenemethanol as substrate
6
pmol/h/ml medium, N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-O-naphthalenemethanol as substrate
6
-
pmol/h/ml medium, beta-D-galactosyl-1,3-N-acetyl-alpha-D-glucosaminyl-O-naphthalenemethanol as substrate
6
-
pmol/h/ml medium, beta-D-galactosyl-1,3-N-acetyl-alpha-D-glucosaminyl-O-naphthalenemethanol as substrate
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
central nervous system, eye disc, leg disc, wing disc. Low activity in salivary gland
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
the enzyme catalyzes a step in glycosaminoglycan synthesis, pathway overview
physiological function
proteoglycans are important components of cell plasma membranes and extracellular matrices of connective tissues. They consist of glycosaminoglycan chains attached to a core protein via a tetrasaccharide linkage, whereby addition of the third residue is catalyzed by galactosyltransferase II, encoded by gene B3GALT6. A crucial role for b3GalT6 in multiple major developmental and pathophysiological processes
malfunction
loss of function of gene b3GalT6 causes a severe deficiency in glycosaminoglycan synthesis and results in the production of immature decorin, lacking its chondroitin sulfate/dermatan sulfate side chain, as well as reduced-to-absent heparan sulfate chains in dermal fibroblasts of affected individuals. Homozygosity mapping and candidate gene sequence analysis in three independent families identified biallelic gene B3GALT6 mutations, including homozygous missense, the families present a severe autosomal-recessive connective tissue disorder characterized by skin fragility, delayed wound healing, joint hyperlaxity and contractures, muscle hypotonia, intellectual disability, and a spondyloepimetaphyseal dysplasia with bone fragility and severe kyphoscoliosis. The phenotype overlaps with several recessive Ehlers-Danlos variants and spondyloepimetaphyseal dysplasia with joint hyperlaxity. Affected individuals' fibroblasts exhibit a large decrease in ability to prime glycosaminoglycan synthesis together with impaired glycanation of the small chondroitin/dermatan sulfate proteoglycan decorin, confirming b3GalT6 loss of function. Dermal electron microcopy discloses abnormalities in collagen fibril organization, in line with the important regulatory role of decorin in this process. A strong reduction in heparan sulfate level is also observed, indicating that enzyme b3GalT6 deficiency alters synthesis of both main types of glycosaminoglycans. In vitro wound healing assay reveals a significant delay in fibroblasts from two index individuals, pointing to a role for glycosaminoglycan defect in impaired wound repair in vivo. Genotype-Phenotype-analysis, overview
malfunction
enzyme deficiency alters synthesis of both main types of glycosaminoglycans and results in impaired wound repair in vivo with abnormal dermal collagen fibril architecture characterized by loosely packed collagen fibrils of variable size and shape
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). B3GT6_HUMAN
329
1
37138
Swiss-Prot
other Location (Reliability: 5)
PVG3_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
378
1
43834
Swiss-Prot
-
A0A0C2E1X5_9BILA
666
0
76291
TrEMBL
other Location (Reliability: 2)
A0A0N4WF95_HAEPC
983
0
110261
TrEMBL
Mitochondrion (Reliability: 4)
A0A158PJC7_ANGCS
623
0
70679
TrEMBL
Secretory Pathway (Reliability: 2)
A0A158RCV2_THECL
1096
0
125496
TrEMBL
other Location (Reliability: 5)
A0A1I7VL20_LOALO
577
0
66191
TrEMBL
other Location (Reliability: 4)
A0A2A6B5W3_PRIPA
1402
0
154872
TrEMBL
other Location (Reliability: 3)
A0A3P7DNV6_WUCBA
1474
0
168276
TrEMBL
other Location (Reliability: 3)
A0A6A5HLS1_CAERE
534
0
61778
TrEMBL
Secretory Pathway (Reliability: 2)
A0A7R9AZY9_TIMSH
549
0
63590
TrEMBL
Secretory Pathway (Reliability: 5)
A0A7R9ESW0_9NEOP
635
0
72073
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8R1TJ88_ONCVO
1001
0
114949
TrEMBL
other Location (Reliability: 2)
A0A8S1EWW4_9PELO
529
0
60586
TrEMBL
other Location (Reliability: 3)
A0A9D4PWQ1_RHISA
673
0
79493
TrEMBL
Mitochondrion (Reliability: 2)
A0A9J6CQU5_POLVA
1202
0
140575
TrEMBL
Secretory Pathway (Reliability: 1)
A0AA39LDI5_9BILA
979
0
110302
TrEMBL
Secretory Pathway (Reliability: 1)
A0AAD4NHQ2_9BILA
502
0
57463
TrEMBL
Secretory Pathway (Reliability: 1)
A0AAV2M4V3_KNICA
1254
0
142825
TrEMBL
Secretory Pathway (Reliability: 1)
K1R5Y1_MAGGI
1136
0
127539
TrEMBL
other Location (Reliability: 3)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
homozygosity mapping and candidate gene sequence analysis in three independent families identified biallelic gene B3GALT6 mutations, including homozygous missense mutations in family 1 (c.619G>C [p.Asp207His]) and family 3 (c.649G>A [p.Gly217Ser]) and compound heterozygous mutations in family 2 (c.323_344del [p.Ala108Glyfs*163], c.619G>C [p.Asp207His]), phenotypes overview
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene B3GALT6, homozygosity mapping and candidate gene sequence analysis in three independent families, genotyping
transient expression as a fusion protein with protein A in chinese hamster ovary cells COS-1
transient expression as a fusion protein with protein A in chinese hamster ovary cells COS-1
transient expression as a fusion protein with protein A in chinese hamster ovary cells COS-1
-
transient expression as a fusion protein with protein A in chinese hamster ovary cells COS-1
-
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
there is no significant effect of Sry-type high-mobility-group box 9 transduction on the gene expression of galactosyltransferase-2
-
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schwartz, N.B.; Rodn, L.
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltranse
J. Biol. Chem.
250
5200-5207
1975
Gallus gallus
brenda
Robinson, J.A.; Robinson, H.C.
Initiation of chondroitin sulphate synthesis by beta-D-galactosides. Substrates for galactosyltransferase II
Biochem. J.
227
805-814
1985
Gallus gallus
brenda
Hwang, H.Y.; Olson, S.K.; Brown, J.R.; Esko, J.D.; Horvitz, H.R.
The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase
J. Biol. Chem.
278
11735-11738
2003
Caenorhabditis elegans (Q9N491)
brenda
Sun, S.; Schilling, B.; Tarantino, L.; Tullius, M.V.; Gibson, B.W.; Munson, R.S., Jr.
Cloning and characterization of the lipooligosaccharide galactosyltransferase II gene of Haemophilus ducreyi
J. Bacteriol.
182
2292-2298
2000
[Haemophilus] ducreyi
brenda
Nakamura, N.; Yamakawa, N.; Sato, T.; Tojo, H.; Tachi, C.; Furukawa, K.
Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development
J. Neurochem.
76
29-38
2001
Mus musculus
brenda
Bai, X.; Zhou, D.; Brown, J.R.; Crawford, B.E.; Hennet, T.; Esko, J.D.
Biosynthesis of the linkage region of glycosaminoglycans. Cloning and activity of galactosyltransferase II, the sixth member of the beta1,3-galactosyltransferase family (beta3GalT6)
J. Biol. Chem.
276
48189-48195
2001
Homo sapiens, Mus musculus
brenda
Ueyama, M.; Takemae, H.; Ohmae, Y.; Yoshida, H.; Toyoda, H.; Ueda, R.; Nishihara, S.
Functional analysis of proteoglycan galactosyltransferase II RNA interference mutant flies
J. Biol. Chem.
283
6076-6084
2008
Drosophila sp. (in: flies)
brenda
Patel, R.Y.; Balaji, P.V.
Fold-recognition and comparative modeling of human beta3GalTI, II, IV, V and VI and beta 3GalNAcT I: Prediction of residues conferring acceptor substrate specificity
J. Mol. Graph. Model.
26
255-268
2007
Homo sapiens, Homo sapiens (Q96L58), Homo sapiens (Q9Y5Z6)
brenda
Tew, S.R.; Pothacharoen, P.; Katopodi, T.; Hardingham, T.E.
SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription
Biochem. J.
414
231-236
2008
Homo sapiens
brenda
Malfait,F.; Kariminejad, A.; Van Damme,T.; Gauche, C.; Syx, D.; Merhi-Soussi, F.; Gulberti, S.; Symoens, S.; Vanhauwaert, S.; Willaert, A.; Bozorgmehr, B.; Kariminejad, M.H.; Ebrahimiadib, N.; Hausser, I.; Huysseune, A.; Fournel-Gigleux, S.; De Paepe, A.
Defective initiation of glycosaminoglycan synthesis due to B3GALT6 mutations causes a pleiotropic Ehlers-Danlos-Syndrome-like connective tissue disorder
Am. J. Hum. Genet.
92
935-945
2013
Homo sapiens (Q96L58)
brenda
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