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Information on EC 2.1.1.38 - O-demethylpuromycin O-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.38 O-demethylpuromycin O-methyltransferase
IUBMB Comments
Puromycin is the antibiotic derived from N6-dimethyladenosine by replacing the 3'-hydroxy group with an amino group and acylating this with 4-O-methyltyrosine.
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The expected taxonomic range for this enzyme is: Streptomyces alboniger
Synonyms
O-demethylpuromycin methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin
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puromycin is the antibiotic derived from N6-dimethyladenosine by replacing the 3'-hydroxyl group with an amino group and acylating this with 4-O-methyltyrosine
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