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IUBMB CommentsThe enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
NovO, more
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S-adenosyl-L-methionine + 8-demethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid
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MetaCyc
novobiocin biosynthesis
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S-adenosyl-L-methionine:8-demethylnovobiocic acid C8-methyltransferase
The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin.
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S-adenosyl-L-methionine + 8-demethylnovobiocic acid
S-adenosyl-L-homocysteine + novobiocic acid
S-adenosyl-L-methionine + 8-demethylnovobiocic acid
S-adenosyl-L-homocysteine + novobiocic acid
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Substrates: -
Products: -
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S-adenosyl-L-methionine + 8-demethylnovobiocic acid
S-adenosyl-L-homocysteine + novobiocic acid
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Substrates: the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin
Products: -
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S-adenosyl-L-methionine + 8-demethylnovobiocic acid
S-adenosyl-L-homocysteine + novobiocic acid
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Substrates: the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin
Products: -
?
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additional information
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no substrate inhibition is observed at 2 mM S-adenosyl-L-methionine
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0.0265
8-demethylnovobiocic acid
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pH 8.5, temperature not specified in the publication
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0.5
8-demethylnovobiocic acid
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pH 8.5, temperature not specified in the publication
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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physiological function
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the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin
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NOVO_STRNV
230
0
25399
Swiss-Prot
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A0A518L2H8_9BACT
231
0
25002
TrEMBL
-
A0A518HLG1_9BACT
231
0
25096
TrEMBL
-
A0A517ZI04_9PLAN
246
0
27501
TrEMBL
-
A0A142XQ99_9BACT
357
0
38711
TrEMBL
-
A0A517T0S4_9BACT
246
0
27055
TrEMBL
-
A0A2W1JMZ5_9CYAN
Acaryochloris thomasi RCC1774
258
0
28976
TrEMBL
-
A0A3N6J7X3_9ACTN
257
0
27696
TrEMBL
-
A0A166CVB8_9EURY
225
0
25960
TrEMBL
-
A0A3B0M3E8_9RHOB
257
0
27672
TrEMBL
-
A0A518AH40_9BACT
220
0
24610
TrEMBL
-
A0A177HQN1_9ACTN
248
0
27308
TrEMBL
-
A0A3N6HX82_9ACTN
263
0
27914
TrEMBL
-
A0A5C5X124_9PLAN
252
0
28898
TrEMBL
-
A0A5C6FTP6_9PLAN
226
0
24589
TrEMBL
-
A0A5C6A426_9BACT
229
0
25130
TrEMBL
-
A0A5B9MKL1_9BACT
213
0
23017
TrEMBL
-
A0A517YMU1_9BACT
359
0
39184
TrEMBL
-
A0A833VAJ5_BURGA
245
0
27446
TrEMBL
-
A0A517XHN1_9PLAN
245
0
27582
TrEMBL
-
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expression in Escherichia coli
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Pacholec, M.; Tao, J.; Walsh, C.T.
CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis
Biochemistry
44
14969-14976
2005
Streptomyces niveus
brenda
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