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Information on EC 2.1.1.101 - macrocin O-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.101 macrocin O-methyltransferase
IUBMB Comments
Requires Mg2+, Mn2+ or Co2+. The 3-hydroxy group of the 2-O-methyl-6-deoxy-D-allose moiety in the macrolide antibiotic macrosin acts as methyl acceptor, generating tylosin, another macrolide antibiotic. Isolated from the bacterium Streptomyces fradiae. Not identical with EC 2.1.1.102, demethylmacrocin O-methyltransferase.
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Word Map
The expected taxonomic range for this enzyme is: Streptomyces fradiae
Synonyms
macrocin methyltransferase, S-adenosyl-L-methionine-macrocin O-methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + macrocin = S-adenosyl-L-homocysteine + tylosin
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also converts lactenosin into desmycocin. Not identical with EC 2.1.1.102 demethylmacrocin O-methyltransferase; the 3-hydroxyl group of a 2-O-methyl-6-deoxy-D-allose residue in the macrolide antibiotic macrosin acts as methyl acceptor
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