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BRENDA support

Information on EC 2.1.1.101 - macrocin O-methyltransferase

for references in articles please use BRENDA:EC2.1.1.101

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IUBMB Comments

Requires Mg2+, Mn2+ or Co2+. The 3-hydroxy group of the 2-O-methyl-6-deoxy-D-allose moiety in the macrolide antibiotic macrosin acts as methyl acceptor, generating tylosin, another macrolide antibiotic. Isolated from the bacterium Streptomyces fradiae. Not identical with EC 2.1.1.102, demethylmacrocin O-methyltransferase.

The enzyme appears in viruses and cellular organisms

Synonyms
macrocin o-methyltransferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + macrocin = S-adenosyl-L-homocysteine + tylosin
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
tylosin biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links