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2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
ferricyanide + NADH
ferrocyanide + NAD+ + H+
-
-
-
r
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
NADP+ + reduced 2,6-dichlorophenolindophenol
diaphorase activity
-
-
?
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
oxidized 2,6-dichlorophenolindophenol + NADPH
reduced 2,6-dichlorophenolindophenol + NADP+ + H+
-
-
-
r
oxidized adrenodoxin + NADH + H+
reduced adrenodoxin + NAD+
-
the enzyme has low affinity for NADH
-
-
?
oxidized adrenodoxin + NADPH + H+
reduced adrenodoxin + NADP+
reduced adrenodoxin + NADP
oxidized adrenodoxin + NADPH + H+
-
-
-
-
?
reduced adrenodoxin + NADP+ + H+
oxidized adrenodoxin + NADPH
reduced ferredoxin + NAD(P)+
oxidized ferredoxin + NAD(P)H
-
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
additional information
?
-
2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
-
the enzyme also has NADPH-ferricyanide activity
-
-
?
2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
diaphorase activity
-
-
?
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
-
-
-
?
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
-
-
-
-
?
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
-
first enzyme in mitochondrial P-450-linked monooxygenase system catalyzing several steps in the biosynthesis of steroid hormones, bile acids or vitamin D3 in various tissues
-
-
?
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
-
-
-
?
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
-
first enzyme in mitochondrial P-450-linked monooxygenase system catalyzing several steps in the biosynthesis of steroid hormones, bile acids or vitamin D3 in various tissues
-
-
?
oxidized adrenodoxin + NADPH + H+
reduced adrenodoxin + NADP+
-
-
285412, 718572, 718822, 718957, 719028, 719386, 719389, 719445, 719482, 719751, 719768, 719775, 719777 -
-
?
oxidized adrenodoxin + NADPH + H+
reduced adrenodoxin + NADP+
-
-
-
?
oxidized adrenodoxin + NADPH + H+
reduced adrenodoxin + NADP+
-
best substrate combination
-
-
?
oxidized adrenodoxin + NADPH + H+
reduced adrenodoxin + NADP+
-
tightly and loosely bound enzyme forms show similar activities
-
-
?
oxidized adrenodoxin + NADPH + H+
reduced adrenodoxin + NADP+
-
-
-
-
?
reduced adrenodoxin + NADP+ + H+
oxidized adrenodoxin + NADPH
-
-
-
-
?
reduced adrenodoxin + NADP+ + H+
oxidized adrenodoxin + NADPH
-
-
-
?
reduced adrenodoxin + NADP+ + H+
oxidized adrenodoxin + NADPH
-
-
-
-
?
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
-
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
-
-
-
-
r
additional information
?
-
-
adrenodoxin stimulates the oxidation of NADPH by 1,4-benzoquinone, catalyzed by NADPH:adrenodoxin reductase. It prevents the enzyme inhibition by NADPH and forms an additional pathway of benzoquinone reduction presumably via reduced adrenodoxin. Adrenodoxin decreases the affinity of the enzyme for NADPH by a limiting factor of 3 and NADP+ decreases the enzyme affinity for adrenodoxin
-
-
?
additional information
?
-
-
anaerobic reduction of AdR with NADPH or the photoreduction of AdR in the presence of NADP+ and EDTA produces a multicomponent equilibrium which is dependent upon the concentration of NADPH and the temperature
-
-
?
additional information
?
-
-
modified adrenodoxin (at His-10, His-66, and His-62 with diethyl dicarbonate) exhibits reduced affinity for adrenodoxin reductase
-
-
?
additional information
?
-
-
NADP+ is also oxidized to 3-carboxamide-4-pyridone adenine dinucleotide phosphate by adrenodoxin reductase in the presence of air oxygen
-
-
?
additional information
?
-
the enzyme contains a second, kinetically distinct and inhibitory pyridine nucleotide-binding site
-
-
?
additional information
?
-
-
the enzyme contains a second, kinetically distinct and inhibitory pyridine nucleotide-binding site
-
-
?
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Carcinoma
Ferredoxin Reductase Is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma.
Colorectal Neoplasms
Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells.
Colorectal Neoplasms
Ferredoxin reductase: pharmacogenomic assessment in colorectal cancer.
Colorectal Neoplasms
Gene expression of ferredoxin reductase predicts outcome in patients with metastatic colorectal cancer treated by 5-fluorouracil plus leucovorin.
Colorectal Neoplasms
Influence of 5-fluorouracil on ferredoxin reductase mRNA splice variants in colorectal carcinomas.
Esophageal Squamous Cell Carcinoma
Ferredoxin Reductase Is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma.
Hearing Loss
Report of a case with ferredoxin reductase (FDXR) gene variants in a Chinese boy exhibiting hearing loss, visual impairment, and motor retardation.
Herpes Zoster
Localization of cytochrome P-450-linked mixed function oxidase and steroid hydroxylations within zones of bovine adrenocortices.
Herpes Zoster
Zonal distribution of cytochromes P-450 and related enzymes of bovine adrenal cortex--quantitative assay of concentrations and total contents.
Iron Overload
Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.
Neoplasms
Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2.
Neoplasms
Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.
Neoplasms
Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2.
Neoplasms
Ferredoxin reductase regulates proliferation, differentiation, cell cycle and lipogenesis but not apoptosis in SZ95 sebocytes.
Neoplasms
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.
Optic Atrophy
Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy.
Tuberculosis
MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51.
Vision Disorders
Report of a case with ferredoxin reductase (FDXR) gene variants in a Chinese boy exhibiting hearing loss, visual impairment, and motor retardation.
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Hanukoglu, I.; Jefcoate, C.R.
Mitochondrial cytochrome P-450sec. Mechanism of electron transport by adrenodoxin
J. Biol. Chem.
255
3057-3061
1980
Bos taurus
brenda
Hiwatashi, A.; Ichikawa, Y.; Maruya, N.; Yamano, T.; Aki, K.
Properties of crystalline reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase from bovine adrenocortical mitochondria. I. Physicochemical properties of holo- and apo-NADPH-adrenodoxin reductase and interaction between non-heme iron proteins and the reductase
Biochemistry
15
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1976
Bos taurus
brenda
Hiwatashi, A.; Ichikawa, Y.; Yamano, T.
Crystallization and properties of reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase of pig adrenocortical mitochondria
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Sus scrofa
brenda
Hanukoglu, I.; Gutfinger, T.; Haniu, M.; Shively, J.E.
Isolation of a cDNA for adrenodoxin reductase (ferredoxin-NADP+ reductase). Implications for mitochondrial cytochrome P-450 systems
Eur. J. Biochem.
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1987
Bos taurus
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Hiwatashi, A.; Ichikawa, Y.; Yamano, T.; Maruya, N.
Properties of crystalline reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase from bovine adrenocortical mitochondria. II. Essential histidyl and cysteinyl residues at the NADPH binding site of NADPH-adrenodoxin reductase
Biochemistry
15
3091-3097
1976
Bos taurus
brenda
Omura, T.; Sanders, E.; Estabrook, R.W.; Cooper, D.Y.; Rosenthal, O.
Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase
Arch. Biochem. Biophys.
117
660-672
1966
Bos taurus
-
brenda
Warburton, R.J.; Seybert D.W.
Structural and functional characterization of bovine adrenodoxin reductase by limited proteolysis
Biochim. Biophys. Acta
1246
39-46
1995
Bos taurus
brenda
Ziegler, G.A.; Schulz, G.E.
Crystal structures of adrenodoxin reductase in complex with NADP+ and NADPH suggesting a mechanism for the electron transfer of an enzyme family
Biochemistry
39
10986-10995
2000
Bos taurus (P08165)
brenda
Kuban R.J.; Marg, A.; Resch, M.; Ruckpaul, K.
Crystallization of bovine adrenodoxin reductase in a new unit cell and its crystallographic characterization
J. Mol. Biol.
234
245-248
1993
Bos taurus
brenda
McLean, K.J.; Scrutton, N.S.; Munro, A.W.
Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA
Biochem. J.
372
317-327
2003
Mycobacterium tuberculosis (P9WIQ3), Mycobacterium tuberculosis
brenda
Tuckey, R.C.; Headlam, M.J.
Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase
J. Steroid Biochem. Mol. Biol.
81
153-158
2002
Homo sapiens
brenda
Ewen, K.M.; Schiffler, B.; Uhlmann-Schiffler, H.; Bernhardt, R.; Hannemann, F.
The endogenous adrenodoxin reductase-like flavoprotein arh1 supports heterologous cytochrome P450-dependent substrate conversions in Schizosaccharomyces pombe
FEMS Yeast Res.
8
432-441
2008
Bos taurus, Homo sapiens
brenda
Liao, W.; Heo, G.; Dodder, N.; Pikuleva, I.; Turko, I.
Optimizing the conditions of a multiple reaction monitoring assay for membrane proteins: Quantification of cytochrome P450 11A1 and adrenodoxin reductase in bovine adrenal cortex and retina
Anal. Chem.
82
5760-5767
2010
Bos taurus
brenda
Kobayashi, K.; Miura, S.; Miki, M.; Ichikawa, Y.; Tagawa, S.
Interaction of NADPH-adrenodoxin reductase with NADP+ as studied by pulse radiolysis
Biochemistry
34
12932-12936
1995
Bos taurus
brenda
Cao, P.R.; Buelow, H.; Dumas, B.; Bernhardt, R.
Construction and characterization of a catalytic fusion protein system: P-45011beta-adrenodoxin reductase-adrenodoxin
Biochim. Biophys. Acta
1476
253-264
2000
Bos taurus
brenda
Sagara, Y.; Wada, A.; Takata, Y.; Waterman, M.; Sekimizu, K.; Horiuchi, T.
Direct expression of adrenodoxin reductase in Escherichia coli and the functional characterization
Biol. Pharm. Bull.
16
627-630
1993
Bos taurus
brenda
Hanukoglu, I.; Hanukoglu, Z.
Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation
Eur. J. Biochem.
157
27-31
1986
Bos taurus
brenda
Hanukoglu, I.; Gutfinger, T.
cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases
Eur. J. Biochem.
180
479-484
1989
Bos taurus
brenda
Mueller, E.C.; Lapko, A.; Otto, A.; Mueller, J.J.; Ruckpaul, K.; Heinemann, U.
Covalently crosslinked complexes of bovine adrenodoxin with adrenodoxin reductase and cytochrome P450scc. Mass spectrometry and Edman degradation of complexes of the steroidogenic hydroxylase system
Eur. J. Biochem.
268
1837-1843
2001
Bos taurus
brenda
de Rosa, M.; Pennati, A.; Pandini, V.; Monzani, E.; Zanetti, G.; Aliverti, A.
Enzymatic oxidation of NADP+ to its 4-oxo derivative is a side-reaction displayed only by the adrenodoxin reductase type of ferredoxin-NADP+ reductases
FEBS J.
274
3998-4007
2007
Bos taurus
brenda
Cenas, N.; Marcinkeviciene, J.; Kulys, J.; Usanov, S.
A negative cooperativity between NADPH and adrenodoxin on binding to NADPH:adrenodoxin reductase
FEBS Lett.
259
338-340
1990
Bos taurus
brenda
Sugiyama, T.; Yamano, T.
Purification and crystallization of NADPH adrenodoxin reductase from bovine adrenocortical mitochondria
FEBS Lett.
52
145-148
1975
Bos taurus
brenda
Hara, T.; Kimura, T.
Active complex between adrenodoxin reductase and adrenodoxin in the cytochrome P-450scc reduction reaction
J. Biochem.
105
601-605
1989
Bos taurus
brenda
Fujii, S.; Nonaka, Y.; Okamoto, M.; Miura, R.
On the ligand-protein and ligand-flavin interactions in NADPH-adrenodoxin reductase as studied by
J. Biochem.
109
144-149
1991
Bos taurus
brenda
Sakamoto, H.; Ohta, M.; Miura, R.; Sugiyama, T.; Yamano, T.; Miyake, Y.
Studies on the reaction mechanism of NADPH-adrenodoxin reductase with NADPH
J. Biochem.
92
1941-1950
1982
Bos taurus
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Hiwatashi, A.; Ichikawa, Y.
Purification and properties of the tightly bound reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase of bovine adrenocortical mitochondria
J. Biochem.
92
335-342
1982
Bos taurus
brenda
Chu, J.; Kimura, T.
Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein)
J. Biol. Chem.
248
2089-2094
1973
Bos taurus
brenda
Driscoll, W.; Omdahl, J.
Kidney and adrenal mitochondria contain two forms of NADPH-adrenodoxin reductase-dependent iron-sulfur proteins. Isolation of the two porcine renal ferredoxins
J. Biol. Chem.
261
4122-4125
1986
Bos taurus
brenda
Miura, S.; Tomita, S.; Ichikawa, Y.
Modification of histidine 56 in adrenodoxin with diethyl pyrocarbonate inhibited the interaction with cytochrome P-450scc and adrenodoxin reductase
J. Biol. Chem.
266
19212-19216
1991
Bos taurus
brenda
Ziegler, G.A.; Vonrhein, C.; Hanukoglu, I.; Schulz, G.E.
The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis
J. Mol. Biol.
289
981-990
1999
Bos taurus (P08165)
brenda
Salamanca-Pinzon, S.; Guengerich, F.
A tricistronic human adrenodoxin reductase-adrenodoxin-cytochrome P450 27A1 vector system for substrate hydroxylation in Escherichia coli
Protein Expr. Purif.
79
231-236
2011
Homo sapiens
brenda
Imamichi, Y.; Mizutani, T.; Ju, Y.; Matsumura, T.; Kawabe, S.; Kanno, M.; Yazawa, T.; Miyamoto, K.
Transcriptional regulation of human ferredoxin reductase through an intronic enhancer in steroidogenic cells
Biochim. Biophys. Acta
1839
33-42
2014
Homo sapiens
brenda
Linares, C.I.; Ferrin, G.; Aguilar-Melero, P.; Gonzalez-Rubio, S.; Rodriguez-Peralvarez, M.; Sanchez-Arago, M.; Chicano-Galvez, E.; Cuezva, J.M.; Montero-Alvarez, J.L.; Muntane, J.; de la Mata, M.
Sensitivity to anti-Fas is independent of increased cathepsin D activity and adrenodoxin reductase expression occurring in NOS-3 overexpressing HepG2 cells
Biochim. Biophys. Acta
1853
1182-1194
2015
Homo sapiens
brenda
Khatri, Y.; Carius, Y.; Ringle, M.; Lancaster, C.R.; Bernhardt, R.
Structural characterization of CYP260A1 from Sorangium cellulosum to investigate the 1alpha-hydroxylation of a mineralocorticoid
FEBS Lett.
590
4638-4648
2016
Bos taurus
brenda
Khatri, Y.; Schifrin, A.; Bernhardt, R.
Investigating the effect of available redox protein ratios for the conversion of a steroid by a myxobacterial CYP260A1
FEBS Lett.
591
1126-1140
2017
Bos taurus
brenda
Abdulmughni, A.; Jozwik, I.K.; Putkaradze, N.; Brill, E.; Zapp, J.; Thunnissen, A.W.; Hannemann, F.; Bernhardt, R.
Characterization of cytochrome P450 CYP109E1 from Bacillus megaterium as a novel vitamin D3 hydroxylase
J. Biotechnol.
243
38-47
2017
Bos taurus
brenda
Hanukoglu, I.
Conservation of the enzyme-coenzyme interfaces in FAD and NADP binding adrenodoxin reductase - a ubiquitous enzyme
J. Mol. Evol.
85
205-218
2017
Bos taurus (P08165)
brenda
Ershov, P.; Mezentsev, Y.; Gilep, A.; Usanov, S.; Buneeva, O.; Medvedev, A.; Ivanov, A.
Isatin-induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction
Protein Sci.
26
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2017
Homo sapiens
brenda
Khalil, M.; Bernhardt, R.; Hellwig, P.
Raman and infrared spectroscopic evidence for the structural changes of the 2Fe2S cluster and its environment during the interaction of adrenodoxin and adrenodoxin reductase
Spectrochim. Acta A. Mol. Biomol. Spectrosc.
183
298-305
2017
Bos taurus
brenda