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EC Tree
IUBMB Comments This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and an FAD reductase, which ensures ample supply of FAD to the monooxygenase.
The enzyme appears in viruses and cellular organisms
Synonyms
gtng_3160, fadh2-utilizing monooxygenase,
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FADH2-utilizing monooxygenase
FADH2-utilizing monooxygenase
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FADH2-utilizing monooxygenase
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GTNG_3160
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anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O
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anthranilate,FAD:oxygen oxidoreductase (3-hydroxylating)
This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and an FAD reductase, which ensures ample supply of FAD to the monooxygenase.
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2-hydroxyphenylacetate + FADH2 + O2
?
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62.79% relative activity
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?
2-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
4-hydroxyphenylacetate + FADH2 + O2
?
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42.7% relative activity
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?
4-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
anthranilate + FADH2 + O2
3-hydroxyanthranilate + FAD
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highest activity
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?
anthranilate + FADH2 + O2
3-hydroxyanthranilate + FAD + H2O
salicylate + FADH2 + O2
?
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49% relative activity
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?
salicylate + FADH2 + O2
? + FAD + H2O
additional information
?
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2-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
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67.8% of the activity with anthranilate
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?
2-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
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67.8% of the activity with anthranilate
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?
4-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
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42.7% of the activity with anthranilate
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?
4-hydroxyphenylacetate + FADH2 + O2
? + FAD + H2O
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42.7% of the activity with anthranilate
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?
anthranilate + FADH2 + O2
3-hydroxyanthranilate + FAD + H2O
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?
anthranilate + FADH2 + O2
3-hydroxyanthranilate + FAD + H2O
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?
salicylate + FADH2 + O2
? + FAD + H2O
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49.6% of the activity with anthranilate
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?
salicylate + FADH2 + O2
? + FAD + H2O
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49.6% of the activity with anthranilate
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?
additional information
?
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no substrate: kynurenine, phenol, 2-nitrobenzylic acid, chlorobenzene, naphthalene, naphthol, toluene or ethylbenzene
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?
additional information
?
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no substrate: kynurenine, phenol, 2-nitrobenzylic acid, chlorobenzene, naphthalene, naphthol, toluene or ethylbenzene
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?
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additional information
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no cofactor: FMNH2
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FADH2
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FADH2
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FADH2-utilizing monooxygenase, no reaction with FMNH2
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151.3
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substrate anthranilate, pH 9.0, 60°C
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9
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9
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assay at, highest activity
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60
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60
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assay at, highest activity
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brenda
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brenda
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HPAH_GEOTN
Geobacillus thermodenitrificans (strain NG80-2)
494
0
56164
Swiss-Prot
-
A0A2S6QDC8_9PROT
496
0
55481
TrEMBL
-
A0A2S6Q7L0_9PROT
496
0
56280
TrEMBL
-
A0A2S6S4Q3_9PROT
483
0
54537
TrEMBL
-
A0A1Y0ND52_9BURK
522
0
58626
TrEMBL
-
A0A2H5YZ54_9BACT
414
0
47328
TrEMBL
-
A0A3P4B5X3_9BURK
503
0
54988
TrEMBL
-
A0A165U0L1_9RHOB
506
0
56896
TrEMBL
-
A0A1B8YJE6_9GAMM
481
0
54511
TrEMBL
-
A0A2S6U561_9PROT
435
0
48300
TrEMBL
-
A0A1C0TYW9_9GAMM
481
0
54852
TrEMBL
-
A0A6G6EDB6_9BURK
494
0
55738
TrEMBL
-
A0A1Y5S1S2_9RHOB
502
0
56439
TrEMBL
-
A0A3P4AZ83_9BURK
506
0
56450
TrEMBL
-
A0A6C0Q8G0_9ACTN
491
0
53513
TrEMBL
-
A0A508SZF0_9BRAD
489
0
53925
TrEMBL
-
A0A644UMQ4_9ZZZZ
503
0
55335
TrEMBL
other Location (Reliability: 3 )
A0A2S6QHF1_9PROT
504
0
56623
TrEMBL
-
A0A6G8NPZ2_9BURK
494
0
55738
TrEMBL
-
A0A2P5VL78_9PROT
488
0
54968
TrEMBL
-
A0A2S6TDN4_9PROT
502
0
56492
TrEMBL
-
A0A1Y5TI39_9PROT
485
0
54682
TrEMBL
-
A0A2S6TZS8_9PROT
497
0
56298
TrEMBL
-
A0A347WBL2_9PROT
483
0
54450
TrEMBL
-
A0A178X6F6_9PSEU
484
0
53256
TrEMBL
-
A0A0M0EHE0_KOMEU
489
0
55363
TrEMBL
-
A0A5E7E5Z2_PSEFL
506
0
56321
TrEMBL
-
A0A1E8AYH0_BACMY
490
0
55639
TrEMBL
-
A0A1E8AY95_BACMY
490
0
55649
TrEMBL
-
A0A5S9P7W8_9RHIZ
506
0
56728
TrEMBL
-
A0A1H8THV0_9RHIZ
495
0
55149
TrEMBL
-
A0A2S6ULV6_9PROT
508
0
57310
TrEMBL
-
A0A2S6R535_9PROT
317
0
35304
TrEMBL
-
A0A238LCX8_9RHOB
506
0
56489
TrEMBL
-
A0A2S6R4A3_9PROT
496
0
55825
TrEMBL
-
A0A0U4NGG8_9BACL
488
0
55017
TrEMBL
-
A0A1Y6ACK6_BACCE
490
0
55700
TrEMBL
-
A0A2P8B2A7_9ACTN
491
0
54666
TrEMBL
-
A0A5E7JWC7_PSEFL
475
0
53122
TrEMBL
-
A0A1Y2MHI6_PSEAH
488
0
54198
TrEMBL
-
A0A1Y5YQS7_BACCE
480
0
54278
TrEMBL
-
A0A2M9MUU2_9BACL
481
0
54497
TrEMBL
-
A0A4V3HZP5_9MYCO
515
0
57471
TrEMBL
-
A0A0G9FDZ8_LACPN
478
0
53348
TrEMBL
-
A0A2S6STT7_9PROT
483
0
54360
TrEMBL
-
A0A5B7V4D1_9ACTN
502
0
55261
TrEMBL
-
A0A1T2ST61_BACCE
477
0
54371
TrEMBL
-
A0A1Y6ANM9_BACCE
476
0
54173
TrEMBL
-
A0A178X727_9PSEU
486
0
53126
TrEMBL
-
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using Ni-NTA chromatography
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expressed in Escherichia coli
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expression in Escherichia coli
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transcription level increases highly when anthranilate is used as the sole carbon source
transcription level increases highly when anthranilate is used as the sole carbon source
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transcription level increases highly when anthranilate is used as the sole carbon source
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Liu, X.; Dong, Y.; Li, X.; Ren, Y.; Li, Y.; Wang, W.; Wang, L.; Feng, L.
Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2
Microbiology
156
589-595
2010
Geobacillus thermodenitrificans, Geobacillus thermodenitrificans NG80-2
brenda
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1.14.14.8 anthranilate 3-monooxygenase (FAD)
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