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Information on EC - 12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase

for references in articles please use BRENDA:EC1.14.14.49
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IUBMB Comments
A cytochrome P450 (heme thiolate) enzyme found in plants. The enzyme acts on jasmonoyl-L-amino acid conjugates that have been hydroxylated at the C-12 position of jasmonic acid by EC, jasmonoyl-L-amino acid 12-hydroxylase, further oxidizing that position to a carboxylate via an aldehyde intermediate. While the best studied substrate is (+)-7-epi-jasmonoyl-L-isoleucine, the enzyme was shown to be active with jasmonoyl-L-phenylalanine, and is likely to be active with other jasmonoyl-amino acid conjugates.
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The expected taxonomic range for this enzyme is: Arabidopsis thaliana
CYP94C1, CYP94C3, jasmonoyl-L-isoleucine-12-hydroxylase, more
a 12-hydroxyjasmonoyl-L-amino acid + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = a 12-hydroxy-12-oxojasmonoyl-L-amino acid + 2 [oxidized NADPH-hemoprotein reductase] + 3 H2O
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overall reaction
a 12-hydroxyjasmonoyl-L-amino acid + [reduced NADPH-hemoprotein reductase] + O2 = a 12-oxojasmonoyl-L-amino acid + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
a 12-oxojasmonoyl-L-amino acid + [reduced NADPH-hemoprotein reductase] + O2 = a 12-hydroxy-12-oxojasmonoyl-L-amino acid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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