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IUBMB Comments A P -450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium . The enzyme is specific for (24S )-cholest-5-ene-3β,24-diol, which is formed mostly in the brain by EC 1.14.14.25 , cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4 , NADPH—hemoprotein reductase.
Synonyms
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24-hydroxycholesterol 7alpha-monooxygenase
CYP39A1 oxysterol 7alpha-hydroxylase
EC 1.14.13.99
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oxysterol 7alpha-hydroxylase CYP39A1
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24-hydroxycholesterol 7alpha-monooxygenase
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24-hydroxycholesterol 7alpha-monooxygenase
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Cyp39a1
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CYP39A1 oxysterol 7alpha-hydroxylase
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CYP39A1 oxysterol 7alpha-hydroxylase
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(24S)-cholest-5-ene-3beta,24-diol + [reduced NADPH-hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3beta,7alpha,24-triol + [oxidized NADPH-hemoprotein reductase] + H2O
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(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
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(24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2
(24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
(24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2
(24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
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Substrates: activity is largely restricted to 24-hydroxycholesterol
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(24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2
(24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
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Substrates: activity is largely restricted to 24-hydroxycholesterol
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(24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2
(24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
Substrates: activity is largely restricted to 24-hydroxycholesterol
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Carcinoma, Hepatocellular
Orphan Nuclear Receptor ROR? Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation.
Cholangiocarcinoma
Association of CYP39A1, RUNX2 and oxidized alpha-1 antitrypsin expression in relation to cholangiocarcinoma progression.
Colorectal Neoplasms
Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
COVID-19
Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology.
Exfoliation Syndrome
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye.
Head and Neck Neoplasms
CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer.
Infections
CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer.
Liver Diseases
Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology.
Neoplasm Metastasis
Association of CYP39A1, RUNX2 and oxidized alpha-1 antitrypsin expression in relation to cholangiocarcinoma progression.
Neutropenia
An SNP in CYP39A1 is associated with severe neutropenia induced by docetaxel.
Prostatic Neoplasms
Ligand-binding properties and catalytic activity of the purified human 24-hydroxycholesterol 7?-hydroxylase, CYP39A1.
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SwissProt
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ciliary nonpigmented of eye
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ciliary nonpigmented epithelium
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sexually dimorphic expression pattern, higher expression in female than in male
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Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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CP7A1_HUMAN
504
1
57661
Swiss-Prot
Secretory Pathway (Reliability: 1 )
CP7A1_MOUSE
503
1
57262
Swiss-Prot
Secretory Pathway (Reliability: 1 )
CP7A1_PIG
501
1
56846
Swiss-Prot
Secretory Pathway (Reliability: 1 )
CP7A1_RABIT
501
1
58090
Swiss-Prot
Secretory Pathway (Reliability: 1 )
CP7A1_RAT
503
1
56883
Swiss-Prot
Secretory Pathway (Reliability: 1 )
CP7B1_HUMAN
506
2
58256
Swiss-Prot
Secretory Pathway (Reliability: 4 )
CP7B1_MOUSE
507
3
58470
Swiss-Prot
Secretory Pathway (Reliability: 2 )
CP39A_HUMAN
469
2
54116
Swiss-Prot
Secretory Pathway (Reliability: 1 )
CP39A_MOUSE
470
0
53575
Swiss-Prot
Secretory Pathway (Reliability: 1 )
M2Y4F8_GALSU
473
1
53969
TrEMBL
Secretory Pathway (Reliability: 1 )
A1A611_XENLA
479
1
54584
TrEMBL
Secretory Pathway (Reliability: 2 )
A0A8B6DLP9_MYTGA
343
1
39917
TrEMBL
other Location (Reliability: 3 )
A0A0B7FGK5_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
509
0
57061
TrEMBL
other Location (Reliability: 3 )
A0A6J8DQC3_MYTCO
425
1
49561
TrEMBL
other Location (Reliability: 4 )
A0A061IKF2_CRIGR
471
1
54195
TrEMBL
Secretory Pathway (Reliability: 1 )
A0A8B6ESD8_MYTGA
285
1
32850
TrEMBL
Secretory Pathway (Reliability: 2 )
A0A8M1N7I9_DANRE
464
2
52864
TrEMBL
Secretory Pathway (Reliability: 1 )
A0A6J8DPF0_MYTCO
447
1
52094
TrEMBL
other Location (Reliability: 4 )
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44000
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x * 44000, SDS-PAGE
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Li-Hawkins, J.; Lund, E.G.; Bronson, A.D.; Russell, D.W.
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol
J. Biol. Chem.
275
16543-16549
2000
Homo sapiens, Mus musculus (Q9JKJ9), Mus musculus
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Ikeda, H.; Ueda, M.; Ikeda, M.; Kobayashi, H.; Honda, Y.
Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye
Lab. Invest.
83
349-355
2003
Bos taurus
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