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EC Tree
IUBMB Comments Requires iron(II) and ascorbate. The product spontaneously undergoes trans-cis isomerization followed by lactonization and cyclization, liberating CoA and forming umbelliferone. The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-feruloyl-CoA (cf. EC 1.14.11.61, feruloyl-CoA 6-hydroxylase).
The enzyme appears in viruses and cellular organisms
Synonyms
C2'H , CYP98A22,
Diox4 ,
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trans-4-coumaroyl-CoA + 2-oxoglutarate + O2 = 2,4-dihydroxycinnamoyl-CoA + succinate + CO2
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(2E)-3-(4-hydroxyphenyl)prop-2-enoyl-CoA,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)
Requires iron(II) and ascorbate. The product spontaneously undergoes trans-cis isomerization followed by lactonization and cyclization, liberating CoA and forming umbelliferone. The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-feruloyl-CoA (cf. EC 1.14.11.61, feruloyl-CoA 6-hydroxylase).
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trans-4-coumaroyl-CoA + 2-oxoglutarate + O2
2,4-dihydroxycinnamoyl-CoA + succinate + CO2
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trans-feruloyl-CoA + 2-oxoglutarate + O2
trans-6-hydroxyferuloyl-CoA + succinate + CO2
reaction of EC 1.14.11.61
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additional information
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no substrates: cinnamic acid, caffeic acid, p-coumaric acid, ferulic acid, cinnamoyl-CoA, caffeoyl-CoA
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trans-4-coumaroyl-CoA + 2-oxoglutarate + O2
2,4-dihydroxycinnamoyl-CoA + succinate + CO2
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trans-feruloyl-CoA + 2-oxoglutarate + O2
trans-6-hydroxyferuloyl-CoA + succinate + CO2
reaction of EC 1.14.11.61
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additional information
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no substrates: cinnamic acid, caffeic acid, p-coumaric acid, ferulic acid, cinnamoyl-CoA, caffeoyl-CoA
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0.05
trans-feruloyl-CoA
pH 7.2, 30°C
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0.014
trans-feruloyl-CoA
pH 7.2, 30°C
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0.111
psoralen
pH 7.2, 30°C
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bifunctional enzyme, catalyzes the activities of EC 1.14.11.61 and EC 1.14.11.62 with equal activities
UniProt
brenda
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expression is induced by UV light
brenda
expression is induced by UV light
brenda
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brenda
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brenda
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F6H21_IPOBA
358
0
40386
Swiss-Prot
other Location (Reliability: 4 )
F6H22_IPOBA
358
0
40405
Swiss-Prot
other Location (Reliability: 3 )
F6H28_IPOBA
359
0
40515
Swiss-Prot
other Location (Reliability: 3 )
DIOX1_RUTGR
369
0
41879
Swiss-Prot
other Location (Reliability: 2 )
DIOX2_RUTGR
369
0
42052
Swiss-Prot
other Location (Reliability: 2 )
DIOX4_RUTGR
367
0
41821
Swiss-Prot
other Location (Reliability: 2 )
H9LJF9_RUTGR
508
0
57512
TrEMBL
-
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expression in Escherichia coli and Nicotiana benthamiana
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in leaf and petiole, expression is induced by UV light
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Vialart, G.; Hehn, A.; Olry, A.; Ito, K.; Krieger, C.; Larbat, R.; Paris, C.; Shimizu, B.; Sugimoto, Y.; Mizutani, M.; Bourgaud, F.
A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. Exhibits p-coumaroyl CoA 2-hydroxylase activity (C2H) A missing step in the synthesis of umbelliferone in plants
Plant J.
70
460-470
2012
Ruta graveolens (H9LJF9)
brenda
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Enzyme Nomenclature
1.14.11.62 trans-4-coumaroyl-CoA 2-hydroxylase
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