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IUBMB Comments Contains iron(II). Catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
N6-methyladenine in DNA
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adenine in DNA
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Synonyms
alkbh1, nmad-1, dna 6ma demethylase,
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ALKBH1
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N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2
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DNA-N6-methyladenosine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)
Contains iron(II). Catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.
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N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
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N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
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N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
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N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
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N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
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N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
the enzyme catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
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N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
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N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
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N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
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N6-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
the enzyme catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Carcinogenesis
ALKBH1 Promotes N6-methyladenine DNA Modifications in Glioblastoma.
Carcinogenesis
N6-Methyladenine DNA Modification in the Human Genome.
Carcinoma
N6-Hydroxymethyladenine: a hydroxylation derivative of N6-methyladenine in genomic DNA of mammals.
Carcinoma, Hepatocellular
AlkB Homologue 1 Demethylates N3-Methylcytidine in mRNA of Mammals.
Decompression Sickness
Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA.
Glioblastoma
ALKBH1 Promotes N6-methyladenine DNA Modifications in Glioblastoma.
Glioblastoma
N6-methyladenine DNA Modification in Glioblastoma.
Hypertension
DNA N6-methyladenine modification in hypertension.
Neoplasm Metastasis
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.
Neoplasms
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.
Neoplasms
N6-methyladenine DNA Modification in Glioblastoma.
Neoplasms
N6-Methyladenine DNA Modification in the Human Genome.
Neoplasms
The stress specific impact of ALKBH1 on tRNA cleavage and tiRNA generation.
Neuroblastoma
The stress specific impact of ALKBH1 on tRNA cleavage and tiRNA generation.
Stomach Neoplasms
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.
Stomach Neoplasms
MiRNA-339-5p suppresses the malignant development of gastric cancer via targeting ALKBH1.
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N2 Bristol
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brenda
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brenda
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SwissProt
brenda
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UniProt
brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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malfunction
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enzyme deletion accelerates the progressive fertility defect of spr-5 mutant worms
malfunction
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enzyme-depleted mesenchymal stem cells exhibit a restricted capacity for bone formation in vivo
physiological function
the enzyme catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons
physiological function
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the enzyme promotes differentiation of early germ cells in fly ovary
physiological function
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enzyme overexpression enhances osteoblastic differentiation of mesenchymal stem cells
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NMAD1_CAEEL
291
0
33292
Swiss-Prot
other Location (Reliability: 2 )
ALKB1_HUMAN
389
0
43832
Swiss-Prot
other Location (Reliability: 5 )
ALKB1_MOUSE
389
0
43746
Swiss-Prot
Mitochondrion (Reliability: 5 )
DMAD_DROME
2860
0
306700
Swiss-Prot
other Location (Reliability: 2 )
ALKB4_HUMAN
302
0
33838
Swiss-Prot
other Location (Reliability: 1 )
ALKB4_MOUSE
300
0
33394
Swiss-Prot
other Location (Reliability: 2 )
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43746
x * 43746, calculated from sequence
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x * 43746, calculated from sequence
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D233A
reduced activity of the recombinant mutant protein
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enzyme expression in human mesenchymal stem cells is upregulated during osteogenic induction
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Wu, T.P.; Wang, T.; Seetin, M.G.; Lai, Y.; Zhu, S.; Lin, K.; Liu, Y.; Byrum, S.D.; Mackintosh, S.G.; Zhong, M.; Tackett, A.; Wang, G.; Hon, L.S.; Fang, G.; Swenberg, J.A.; Xiao, A.Z.
DNA methylation on N-adenine in mammalian embryonic stem cells
Nature
532
329-333
2016
Mus musculus (P0CB42), Mus musculus
brenda
Zhang, G.; Huang, H.; Liu, D.; Cheng, Y.; Liu, X.; Zhang, W.; Yin, R.; Zhang, D.; Zhang, P.; Liu, J.; Li, C.; Liu, B.; Luo, Y.; Zhu, Y.; Zhang, N.; He, S.; He, C.; Wang, H.; Chen, D.
N6-methyladenine DNA modification in Drosophila
Cell
161
893-906
2015
Drosophila melanogaster
brenda
Ye, F.; Zhang, L.; Jin, L.; Zheng, M.; Jiang, H.; Luo, C.
Repair of methyl lesions in RNA by oxidative demethylation
MedChemComm
5
1797-1803
2014
Homo sapiens (Q13686)
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brenda
Zhou, C.; Liu, Y.; Li, X.; Zou, J.; Zou, S.
DNA N6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs
Bone Res.
4
16033
2016
Homo sapiens
brenda
Greer, E.L.; Blanco, M.A.; Gu, L.; Sendinc, E.; Liu, J.; Aristizabal-Corrales, D.; Hsu, C.H.; Aravind, L.; He, C.; Shi, Y.
DNA methylation on N6-adenine in C. elegans
Cell
161
868-878
2015
Caenorhabditis elegans
brenda
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1.14.11.51 DNA N6-methyladenine demethylase
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