Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 1.14.11.51 - DNA N6-methyladenine demethylase

for references in articles please use BRENDA:EC1.14.11.51

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

Contains iron(II). Catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
N6-methyladenine in DNA
+
+
=
adenine in DNA
+
+
+

Synonyms
nmad-1, dna 6ma demethylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2
show the reaction diagram
-
-
-
-
Highest Expressing Human Cell Lines
Cell Line Links Gene Links