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Contains iron(II). Catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
N6-methyladenine in DNA
adenine in DNA
alkbh1, nmad-1, dna 6ma demethylase, more
N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2
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