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Information on EC 1.14.11.49 - uridine-5'-phosphate dioxygenase

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IUBMB Comments
The enzyme catalyses a net dephosphorylation and oxidation of UMP to generate 5'-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C7-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. Requires Fe2+.
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Word Map
The expected taxonomic range for this enzyme is: unclassified Streptomyces
Synonyms
alpha-ketoglutarate:UMP dioxygenase, alpha-KG:UMP dioxygenase, LIPL, UMP:alpha-ketoglutarate dioxygenase, uridine-5-monophosphate alpha-ketoglutarate dioxygenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UMP + 2-oxoglutarate + O2 = 5'-dehydrouridine + succinate + CO2 + phosphate
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