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Information on EC 1.1.1.91 - aryl-alcohol dehydrogenase (NADP+)
for references in articles please use BRENDA:EC1.1.1.91
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)
IUBMB Comments
Also acts on some aliphatic aldehydes, but cinnamaldehyde was the best substrate found.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
showSynonyms
aad14, aryl-alcohol dehydrogenase (nadp+), more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AAD
AAD14
Aad14p
AAD4
Aad4p
aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate) coniferyl alcohol dehydrogenase
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aryl-alcohol dehydrogenase
NADPH-linked benzaldehyde reductase
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ScAad14p protein
ScAad4p protein
SDR A5
SDR B3
short-chain dehydrogenase/reductase
AAD
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short-chain dehydrogenase/reductase
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
aryl-alcohol:NADP+ oxidoreductase
Also acts on some aliphatic aldehydes, but cinnamaldehyde was the best substrate found.
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CAS REGISTRY NUMBER
COMMENTARY
37250-27-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(E)-oct-2-enal + NADPH + H+
trans-2-octen-1-ol + NADP+
Substrates: -
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1-butanol + NADP+
butyraldehyde + NADPH + H+
Substrates: 56% activity compared to crotyl alcohol
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1-propanol + NADP+
propionaldehyde + NADPH + H+
Substrates: 17.4% activity compared to crotyl alcohol
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2,4-dimethoxybenzyl alcohol + NADP+
2,4-dimethoxybenzyl aldehyde + NADPH + H+
Substrates: -
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2-fluorobenzaldehyde + NADPH
2-fluorobenzyl alcohol + NADP+
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Substrates: relative activity: 27% (reference substrate: 3,4-dimethoxybenzaldehyde)
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2-hydroxyacetophenone + NADPH + H+
(S)-1,2-phenylethanediol + NADP+
Substrates: -
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2-methoxybenzaldehyde + NADPH
2-methoxybenzyl alcohol + NADP+
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Substrates: relative activity: 58% (reference substrate: 3,4-dimethoxybenzaldehyde)
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2-nitrobenzaldehyde + NADPH
2-nitrobenzyl alcohol + NADP+
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Substrates: relative activity: 57% (reference substrate: 3,4-dimethoxybenzaldehyde)
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2-nitrobenzaldehyde + NADPH + H+
2-nitrobenzyl alcohol + NADP+
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Substrates: -
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3,4,5-trimethoxybenzaldehyde + NADPH
3,4,5-trimethoxybenzyl alcohol + NADP+
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Substrates: -
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3,4-dihydroxybenzaldehyde + NADPH
3,4-dihydroxybenzyl alcohol + NADP+
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Substrates: -
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3,4-dimethoxybenzaldehyde + NADH
3,4-dimethoxybenzyl alcohol + NAD+
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Substrates: -
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3,4-dimethoxybenzyl alcohol + NADP+
?
Substrates: -
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3,4-dimethoxybenzyl alcohol + NADP+
veratraldehyde + NADPH + H+
Substrates: -
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3-chlorobenzaldehyde + NADPH
3-chlorobenzyl alcohol + NADP+
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Substrates: relative activity: 73% (reference substrate: 3,4-dimethoxybenzaldehyde)
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3-fluorobenzaldehyde + NADPH
3-fluorobenzyl alcohol + NADP+
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Substrates: relative activity: 69% (reference substrate: 3,4-dimethoxybenzaldehyde)
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3-hydroxy-4-methoxy-benzaldehyde + NADPH
3-hydroxy-4-methoxy-benzyl alcohol + NADP+
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Substrates: relative activity: 17% (reference substrate: 3,4-dimethoxybenzaldehyde)
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3-hydroxy-4-methoxybenzaldehyde + NADPH + H+
3-hydroxy-4-methoxybenzyl alcohol + NADP+
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Substrates: -
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3-methoxybenzaldehyde + NADPH
3-methoxybenzyl alcohol + NADP+
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Substrates: relative activity: 117% (reference substrate: 3,4-dimethoxybenzaldehyde)
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3-nitrobenzaldehyde + NADPH
3-nitrobenzyl alcohol + NADP+
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Substrates: relative activity: 25% (reference substrate: 3,4-dimethoxybenzaldehyde)
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3-phenylpropionaldehyde + NADPH + H+
3-phenylpropionyl alcohol + NADP+
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Substrates: -
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4-(hydroxymethyl)benzoic acid + NAD+
? + NADH + H+
Substrates: -
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4-benzyloxy-3-methoxybenzaldehyde + NADPH + H+
4-benzyloxy-3-methoxybenzyl alcohol + NADP+
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Substrates: -
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4-chlorobenzaldehyde + NADPH
4-chlorobenzyl alcohol + NADP+
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Substrates: relative activity: 61% (reference substrate: 3,4-dimethoxybenzaldehyde)
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4-fluorobenzaldehyde + NADPH
4-fluorobenzyl alcohol + NADP+
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Substrates: relative activity: 29% (reference substrate: 3,4-dimethoxybenzaldehyde)
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4-hydroxy-3-methoxy-benzaldehyde + NADPH
4-hydroxy-3-methoxy-benzyl alcohol + NADP+
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Substrates: relative activity: 19% (reference substrate: 3,4-dimethoxybenzaldehyde)
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4-hydroxy-3-methoxybenzaldehyde + NADPH + H+
4-hydroxy-3-methoxybenzyl alcohol + NADP+
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Substrates: -
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4-hydroxybenzaldehyde + NADPH
4-hydroxybenzyl alcohol + NADP+
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Substrates: relative activity: 34% (reference substrate: 3,4-dimethoxybenzaldehyde)
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4-hydroxybenzaldehyde + NADPH + H+
4-hydroxybenzyl alcohol + NADP+
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Substrates: -
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4-methoxybenzaldehyde + NADPH
4-methoxybenzyl alcohol + NADP+
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Substrates: relative activity: 110% (reference substrate: 3,4-dimethoxybenzaldehyde)
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4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
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Substrates: -
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4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
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Substrates: relative activity: 31% (reference substrate: 3,4-dimethoxybenzaldehyde)
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4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzyl alcohol + NADP+
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Substrates: -
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5-(hydroxymethyl)-2-furaldehyde + NADPH + H+
(furan-2,5-diyl)dimethanol + NADP+
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Substrates: relative activity: 36% (reference substrate: 3,4-dimethoxybenzaldehyde)
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benzyl alcohol + NAD+
benzaldehyde + NADPH + H+
Substrates: oxidation of benzyl alcohol at pH 9.6 is NAD+-dependent while NADP+ did not yield detectable activity under the same conditions
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cinnamaldehyde + NADPH + H+
cinnamoyl alcohol + NADP+
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Substrates: -
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coniferyl alcohol + NADP+
coniferyl aldehyde + NADPH + H+
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Substrates: -
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coniferyl aldehyde + NADH + H+
coniferyl alcohol + NAD+
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Substrates: -
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crotonaldehyde + NADPH + H+
crotonyl alcohol + NADP+
Substrates: -
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crotonyl alcohol + NADP+
crotonaldehyde + NADPH + H+
Substrates: highest oxidative activity with crotyl alcohol
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decanal + NADPH
decanol + NADP+
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Substrates: relative activity: 2% (reference substrate: 3,4-dimethoxybenzaldehyde)
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heptaldehyde + NADPH
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Substrates: relative activity: 26% (reference substrate: 3,4-dimethoxybenzaldehyde)
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hexanal + NADPH
hexanol + NADP+
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Substrates: relative activity: 47% (reference substrate: 3,4-dimethoxybenzaldehyde)
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m-bromobenzaldehyde + NADPH + H+
m-bromobenzyl alcohol + NADP+
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Substrates: -
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m-chlorobenzaldehyde + NADPH + H+
m-chlorobenzyl alcohol + NADP+
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Substrates: -
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m-fluorobenzaldehyde + NADPH + H+
m-fluorobenzyl alcohol + NADP+
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Substrates: -
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m-hydroxybenzaldehyde + NADPH + H+
m-hydroxybenzyl alcohol + NADP+
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Substrates: -
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m-nitrobenzaldehyde + NADPH
m-nitrobenzyl alcohol + NADP+
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Substrates: -
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nonanal + NADPH
nonanol + NADP+
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Substrates: relative activity: 3% (reference substrate: 3,4-dimethoxybenzaldehyde)
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o-bromobenzaldehyde + NADPH + H+
o-bromobenzyl alcohol + NADP+
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Substrates: -
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o-chlorobenzaldehyde + NADPH + H+
o-chlorobenzyl alcohol + NADP+
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Substrates: -
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o-fluorobenzaldehyde + NADPH + H+
o-fluorobenzyl alcohol + NADP+
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Substrates: -
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octanal + NADPH
octanol + NADP+
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Substrates: relative activity: 37% (reference substrate: 3,4-dimethoxybenzaldehyde)
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p-aminobenzyl alcohol + NADP+
p-aminobenzaldehyd + NADPH
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Substrates: -
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p-bromobenzaldehyde + NADPH + H+
p-bromobenzyl alcohol + NADP+
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Substrates: -
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p-chlorobenzaldehyde + NADPH + H+
p-chlorobenzyl alcohol + NADP+
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Substrates: -
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p-fluorobenzaldehyde + NADPH + H+
p-fluorobenzyl alcohol + NADP+
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Substrates: -
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p-hydroxybenzaldehyde + NADPH + H+
p-hydroxybenzyl alcohol + NADP+
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Substrates: -
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p-methylbenzaldehyde + NADPH
p-methylbenzyl alcohol + NADP+
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Substrates: -
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pentanal + NADPH
pentanol + NADP+
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Substrates: relative activity: 8% (reference substrate: 3,4-dimethoxybenzaldehyde)
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phenylacetaldehyde + NADPH
phenylethanol + NADP+
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Substrates: relative activity: 109 (reference substrate: 3,4-dimethoxybenzaldehyde)
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phenylacetaldehyde + NADPH + H+
phenylethanol + NADP+
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Substrates: -
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salicyl alcohol + NADP+
p-hydroxybenzaldehyde + NADPH
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Substrates: i.e. p-hydroxybenzyl alcohol
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sinapyl alcohol + NADP+
sinapyl aldehyde + NADPH + H+
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Substrates: -
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trans-4-phenyl-3-buten-2-one + NADPH + H+
?
Substrates: -
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trans-cinnamaldehyde + NADPH
?
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Substrates: relative activity: 39% (reference substrate: 3,4-dimethoxybenzaldehyde)
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vanillin + NADPH + H+
vanillic alcohol + NADP+
Substrates: -
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veratraldehyde + NADPH + H+
3,4-dimethoxybenzyl alcohol + NADP+
Substrates: -
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veratryl alcohol + NADP+
veratraldehyde + NADPH
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Substrates: i.e. 3,4-dimethoxybenzyl alcohol
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(R)-1-phenylethanol + NAD+
1-phenylacetaldehyde + NADH + H+
Substrates: -
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(R)-1-phenylethanol + NAD+
1-phenylacetaldehyde + NADH + H+
Substrates: -
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(R)-2-octanol + NADPH + H+
?
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
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Substrates: -
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(S)-1-phenylethanol + NADP+
1-phenylacetaldehyde + NADPH + H+
Substrates: -
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(S)-1-phenylethanol + NADP+
1-phenylacetaldehyde + NADPH + H+
Substrates: -
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(S)-2-octanol + NADPH + H+
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Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
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Substrates: -
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2-methyl-propanol + NADPH + H+
?
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
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Substrates: -
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3,4-dimethoxybenzaldehyde + NADPH
3,4-dimethoxybenzyl alcohol + NADP+
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Substrates: -
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3,4-dimethoxybenzaldehyde + NADPH
3,4-dimethoxybenzyl alcohol + NADP+
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Substrates: relative activity: 100% (reference substrate: 3,4-dimethoxybenzaldehyde)
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3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzol + NADP+
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Substrates: -
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3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzol + NADP+
Substrates: -
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3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzol + NADP+
Substrates: -
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3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzol + NADP+
Substrates: -
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3,5-dimethoxybenzaldehyde + NADPH
3,5-dimethoxybenzyl alcohol + NADP+
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Substrates: -
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3,5-dimethoxybenzaldehyde + NADPH
3,5-dimethoxybenzyl alcohol + NADP+
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Substrates: relative activity: 110% (reference substrate: 3,4-dimethoxybenzaldehyde)
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4-methoxybenzyl alcohol + NADP+
4-methoxybenzaldehyde + NADPH
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Substrates: i.e. anisic alcohol
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4-methoxybenzyl alcohol + NADP+
4-methoxybenzaldehyde + NADPH
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Substrates: i.e. anisic alcohol
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4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzylalcohol + NADP+
Substrates: -
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4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzylalcohol + NADP+
Substrates: -
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4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzylalcohol + NADP+
Substrates: -
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benzaldehyde + NADPH
benzyl alcohol + NADP+
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Substrates: -
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benzaldehyde + NADPH
benzyl alcohol + NADP+
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Substrates: relative activity: 42% (reference substrate: 3,4-dimethoxybenzaldehyde)
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benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
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Substrates: -
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benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
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Substrates: -
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benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
Substrates: reduction of benzaldehyde at pH 6.0 is NADPH-dependent while NADH does not yield detectable activity under the same conditions
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benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
Substrates: highest reductive activity with benzaldehyde
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benzyl alcohol + NADP+
benzaldehyde + NADPH
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Substrates: -
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benzyl alcohol + NADP+
benzaldehyde + NADPH
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Substrates: enzyme participates in benzoate reduction
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benzyl alcohol + NADP+
benzaldehyde + NADPH
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Substrates: enzyme participates in benzoate reduction
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benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
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Substrates: -
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benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
Substrates: -
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benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
Substrates: 41.7% activity compared to crotyl alcohol
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cinnamic alcohol + NADP+
cinnamic aldehyde + NADPH
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Substrates: -
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cinnamic alcohol + NADP+
cinnamic aldehyde + NADPH
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Substrates: -
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coniferyl alcohol + NADP+
coniferylaldehyde + NADPH + H+
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Substrates: -
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coniferyl alcohol + NADP+
coniferylaldehyde + NADPH + H+
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Substrates: i.e. 4-hydroxy-3-methoxycinnamic alcohol
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coniferyl alcohol + NADP+
coniferylaldehyde + NADPH + H+
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Substrates: -
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heptanal + NADPH + H+
heptanol + NADP+
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Substrates: -
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heptanal + NADPH + H+
heptanol + NADP+
Substrates: -
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heptanal + NADPH + H+
heptanol + NADP+
Substrates: -
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heptanal + NADPH + H+
heptanol + NADP+
Substrates: -
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hexanal + NADPH + H+
hexanol + NADP+
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Substrates: -
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hexanal + NADPH + H+
hexanol + NADP+
Substrates: -
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hexanal + NADPH + H+
hexanol + NADP+
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hexanal + NADPH + H+
hexanol + NADP+
Substrates: -
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additional information
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Substrates: no activity is detected for isoform SDR A5 with isobutyraldehyde, isovaleraldehyde, 2-heptanone, 2-phenylacetaldehyde, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 1-phenylpropane-1,2-dione, benzophenone, (R)-(-)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, rac-3-methyl-2-butanol, (S)-4-methyl-2-pentanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, (R)-2-octanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, rac-decan-1,2-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin. No activity is detected for isoform SDR B3 with isobutyraldehyde, 2-hexanone, 2-heptanone, 2-octanone, ethyl acetoacetate, acetophenone, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 4-(4-hydroxyphenyl)-2-butanone, 1-phenylpropane-1,2-dione, benzophenone, rac-benzoin, (R)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin
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additional information
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Substrates: the enzyme accepts both NAD+ and NADP+. However, purified enzyme shows strong preference for NADP+
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additional information
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Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
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Substrates: no activity is detected for isoform SDR A5 with isobutyraldehyde, isovaleraldehyde, 2-heptanone, 2-phenylacetaldehyde, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 1-phenylpropane-1,2-dione, benzophenone, (R)-(-)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, rac-3-methyl-2-butanol, (S)-4-methyl-2-pentanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, (R)-2-octanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, rac-decan-1,2-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin. No activity is detected for isoform SDR B3 with isobutyraldehyde, 2-hexanone, 2-heptanone, 2-octanone, ethyl acetoacetate, acetophenone, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 4-(4-hydroxyphenyl)-2-butanone, 1-phenylpropane-1,2-dione, benzophenone, rac-benzoin, (R)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin
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additional information
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Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
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Substrates: the enzyme accepts both NAD+ and NADP+. However, purified enzyme shows strong preference for NADP+
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additional information
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Substrates: broad substrate specificity towards both aromatic and to a lesser extent aliphatic aldehydes
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?
additional information
?
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Substrates: substrate specificity, overview. PcAad1p is active on a broader spectrum of aryl-aldehyde substrates. PcAad1p can also act as an oxidase against several aliphatic and aromatic alcohols (at pH 10.3, with NADP+ as a cofactor)
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Substrates: substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
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additional information
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Substrates: substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
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additional information
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Substrates: substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
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additional information
?
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Substrates: substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
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additional information
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Substrates: substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
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additional information
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Substrates: substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
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additional information
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Substrates: substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
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additional information
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Substrates: substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
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additional information
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Substrates: substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
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additional information
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Substrates: substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
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additional information
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Substrates: substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
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additional information
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Substrates: substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
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additional information
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Substrates: low activity with aliphatic aldehydes
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additional information
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Substrates: no activity with NADH or NAD+
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
coniferyl alcohol + NADP+
coniferyl aldehyde + NADPH + H+
-
Substrates: -
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?
benzyl alcohol + NADP+
benzaldehyde + NADPH
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Substrates: enzyme participates in benzoate reduction
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r
benzyl alcohol + NADP+
benzaldehyde + NADPH
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Substrates: enzyme participates in benzoate reduction
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r
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD+
oxidation of benzyl alcohol at pH 9.6 is NAD+-dependent
NADPH
-
needs NADPH as cofactor, with NADH the reaction is less than 1% of the rate with NADPH
NADPH
-
strict requirement for NADPH, with NADH only 1% of the reduction rate obtained with NADPH achieved
NADPH
reduction of benzaldehyde at pH 6.0 is NADPH-dependent
additional information
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the enzyme is active with NADPH and NADH
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
Ca2+, Na+, Mg2+, Mn2+, and K+ have no significant effect on the enzyme activity
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
coniferyl alcohol
-
inhibited by an excess of the substrate from 0.017 mM
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMA