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Information on EC 1.1.1.52 - 3alpha-hydroxycholanate dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.1.1.52

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IUBMB Comments

Also acts on other 3α-hydroxysteroids with an acidic side-chain. cf. EC 1.1.1.392, 3α-hydroxycholanate dehydrogenase (NADP+).

The enzyme appears in viruses and cellular organisms

Synonyms
alpha-hydroxy-cholanate dehydrogenase, dehydrogenase, 3alpha-hydroxycholanate, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
lithocholate + NAD+ = 3-oxo-5beta-cholan-24-oate + NADH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
bile acid 7alpha-dehydroxylation, bile acid 7beta-dehydroxylation, bile acids 3-O-epimerization, iso-bile acids biosynthesis I
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