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Information on EC 1.1.1.349 - norsolorinic acid ketoreductase
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.349 norsolorinic acid ketoreductase
IUBMB Comments
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
The enzyme appears in viruses and cellular organisms
- 1.1.1.349
-
orphan
- aflatoxin
- parasiticus
-
neuron-derived
-
ngfi-b
- receptor-1
-
aflatoxigenic
-
efs-induced
-
aflatoxin-inducing
-
carbapenem-hydrolyzing
showSynonyms
nor-1, nor-1 protein, nor-i, norsolorinic acid ketoreductase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
aflD
-
-
-
-
nor-1
nor-1 protein
nor-I
nor-1
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
(1'S,5'S)-averufin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(1'S)-averantin:NADP+ oxidoreductase
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1'S)-averantin + NADP+
norsolorinic acid + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
(1'S)-averantin + NADP+
norsolorinic acid + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
Substrates: -
Products: -
Products: -
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
Substrates: -
Products: -
Products: -
r
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
Substrates: -
Products: -
Products: -
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
Substrates: -
Products: -
Products: -
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
Substrates: -
Products: -
Products: -
r
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
Substrates: -
Products: -
Products: -
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme cannot use (1ĀR)-averantin as substrate in the reverse reaction
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme cannot use (1ĀR)-averantin as substrate in the reverse reaction
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
Substrates: -
Products: -
Products: -
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
Substrates: -
Products: -
Products: -
?
norsolorinic acid + NADPH + H+
(1'S)-averantin + NADP+
-
Substrates: -
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Aneurysm
High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice.
Atherosclerosis
Expression, purification, and initial structural characterization of rat orphan nuclear receptor NOR-1 LBD domain.
Atherosclerosis
Neuron-derived orphan receptor-1 (NOR-1) modulates vascular smooth muscle cell proliferation.
Brain Injuries, Traumatic
Neuron-derived orphan receptor 1 transduces survival signals in neuronal cells in response to hypoxia-induced apoptotic insults.
Brain Ischemia
Expression of Nuclear Orphan Receptors Ngfi-B/Tr3, Nurr1 And Nor-1 after Global Brain Ischemia in Rat.
Brain Ischemia
Inductin of neuron-derived orphan receptor-1 in the dentate gyrus of the hippocampal formation following transient global ischemia in the rat.
Breast Neoplasms
Early induction of the orphan nuclear receptor NOR-1 during cell death of the human breast cancer cell line MCF-7.
Breast Neoplasms
Retinoic acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast cancer cell line MCF-7.
Carcinogenesis
Cancer chemopreventive activity of phenylpropanoid esters of sucrose, vanicoside B and lapathoside A, from Polygonum lapathifolium.
Carcinogenesis
Neuron-Derived Orphan Receptor 1 Promotes Proliferation of Quiescent Hepatocytes.
Carcinogenesis
The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas.
Carcinoma
NOR-1 distinguishes acinic cell carcinoma from its mimics on fine-needle aspiration biopsy specimens.
Carcinoma
NOR-1 immunostain is a good method to confirm the diagnosis of an oral acinic cell carcinoma.
Carcinoma, Acinar Cell
NOR-1 distinguishes acinic cell carcinoma from its mimics on fine-needle aspiration biopsy specimens.
Carcinoma, Acinar Cell
NOR-1 immunostain is a good method to confirm the diagnosis of an oral acinic cell carcinoma.
Cardiomegaly
Neuron-derived orphan receptor-1 modulates cardiac gene expression and exacerbates angiotensin II-induced cardiac hypertrophy.
Chondrosarcoma
Expression, purification, and initial structural characterization of rat orphan nuclear receptor NOR-1 LBD domain.
Chondrosarcoma
The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas.
Glomerulonephritis
Early induction of the NGFI-B/Nur77 family genes in nephritis induced by anti-glomerular basement membrane antibody.
Glucose Intolerance
Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.
Hypercholesterolemia
Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation.
Hyperlipidemias
Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation.
Infections
Efficacies of imipenem, meropenem, cefepime, and ceftazidime in rats with experimental pneumonia due to a carbapenem-hydrolyzing beta-lactamase-producing strain of Enterobacter cloacae.
Infections
Infection and colonization of peanut pods by Aspergillus parasiticus and the expression of the aflatoxin biosynthetic gene, nor-1, in infection hyphae.
Infertility, Female
NADPH oxidases NOX-1 and NOX-2 require the regulatory subunit NOR-1 to control cell differentiation and growth in Neurospora crassa.
Insulin Resistance
6-Mercaptopurine Augments Glucose Transport Activity in Skeletal Muscle Cells in Part via a Mechanism Dependent upon Orphan Nuclear Receptor NR4A3.
Insulin Resistance
Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.
Neoplasms
Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia.
Neoplasms
Cancer chemopreventive activity of phenylpropanoid esters of sucrose, vanicoside B and lapathoside A, from Polygonum lapathifolium.
Neoplasms
Expression of NOR-1 and its closely related members of the steroid/thyroid hormone receptor superfamily in human neuroblastoma cell lines.
Neoplasms
Neuron-Derived Orphan Receptor 1 Promotes Proliferation of Quiescent Hepatocytes.
Neoplasms
Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo.
Neoplasms
NOR-1 distinguishes acinic cell carcinoma from its mimics on fine-needle aspiration biopsy specimens.
Neoplasms
The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas.
Nephritis
Early induction of the NGFI-B/Nur77 family genes in nephritis induced by anti-glomerular basement membrane antibody.
Neuroblastoma
Expression of NOR-1 and its closely related members of the steroid/thyroid hormone receptor superfamily in human neuroblastoma cell lines.
Neuroblastoma
The constitutive and inducible expression of Nurr1, a key regulator of dopaminergic neuronal differentiation, in human neural and non-neural cell lines.
Pneumonia
Efficacies of imipenem, meropenem, cefepime, and ceftazidime in rats with experimental pneumonia due to a carbapenem-hydrolyzing beta-lactamase-producing strain of Enterobacter cloacae.
Seizures
nor-1 regulates hippocampal axon guidance, pyramidal cell survival, and seizure susceptibility.
Vascular Diseases
Over-expression of Neuron-derived Orphan Receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury.
Vascular System Injuries
Over-expression of Neuron-derived Orphan Receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
malfunction
inactivation of the nor-1 gene leads to accumulation of norsolorinic acid and production of reduced levels of aflatoxin
malfunction
-
inactivation of the nor-1 gene leads to accumulation of norsolorinic acid and production of reduced levels of aflatoxin
-
malfunction
-
inactivation of the nor-1 gene leads to accumulation of norsolorinic acid and production of reduced levels of aflatoxin
-
metabolism
the nor-I gene is functionally involved in aflatoxin biosynthesis
metabolism
-
the enzyme is involved in the aflatoxin biosynthetic pathways. The accumulation of aflatoxins on rice grains attacked by Aspergillus species represent a serious threat to the consumers
metabolism
-
the enzyme is involved in the aflatoxin biosynthetic pathways. The accumulation of aflatoxins on rice grains attacked by Aspergillus species represent a serious threat to the consumers
metabolism
-
the enzyme is involved in the aflatoxin biosynthetic pathways. The accumulation of aflatoxins on rice grains attacked by Aspergillus species represent a serious threat to the consumers
metabolism
-
the nor-I gene is functionally involved in aflatoxin biosynthesis
-
metabolism
-
the nor-I gene is functionally involved in aflatoxin biosynthesis
-
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). NOR1_DOTSN
Dothistroma septosporum (strain NZE10 / CBS 128990)
268
0
28762
Swiss-Prot
other Location (Reliability: 3)
STCE_EMENI
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
263
0
28081
Swiss-Prot
other Location (Reliability: 3)
AFLD_ASPPU
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
271
0
29569
Swiss-Prot
other Location (Reliability: 2)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
32000
-
x * 32000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected
36000
-
x * 36000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
-
x * 32000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected
?
-
x * 36000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected
?
-
x * 32000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected
-
?
-
x * 36000, SDS-PAGE, two recombinant Nor-1 proteins with apparent 32000 (major) and 36000 Da (minor) masses are detected
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yabe, K.; Matsuyama, Y.; Ando, Y.; Nakajima, H.; Hamasaki, T.
Stereochemistry during aflatoxin biosynthesis: Conversion of norsolorinic acid to averufin
Appl. Environ. Microbiol.
59
2486-2492
1993
Aspergillus parasiticus, Aspergillus parasiticus NIAH-26
brenda
Trail, F.; Chang, P.K.; Cary, J.; Linz, J.E.
Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus
Appl. Environ. Microbiol.
60
4078-4085
1994
Aspergillus parasiticus (Q00278), Aspergillus parasiticus, Aspergillus parasiticus NRRL 5862 (Q00278)
brenda
Zhou, R.; Linz, J.E.
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus
Appl. Environ. Microbiol.
65
5639-5641
1999
Aspergillus parasiticus, Aspergillus parasiticus ATCC 56774
brenda
Douksouna, Y.; Masanga, J.; Nyerere, A.; Runo, S.; Ambang, Z.
Towards managing and controlling aflatoxin producers within Aspergillus species in infested rice grains collected from local markets in Kenya
Toxins
11
544
2019
Aspergillus flavus, Aspergillus parasiticus, Aspergillus nomiae
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.349)
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Release 2023.1 (January 2023)
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